Bisphosphonate sequestering agents. Synthesis and preliminary evaluation for in vitro and in vivo uranium(VI) chelation

European Journal of Medicinal Chemistry

Volumn 43, Issue 12, 2008, Pages 2768-2777

  Sawicki, Marcin ^a   Lecerclé, Delphine ^a   Grillon, Gérard ^b   Le Gall, Béatrice ^b   Sérandour, Anne Laure ^b   Poncy, Jean Luc ^b   Bailly, Théodorine ^c   Burgada, Ramon ^c   Lecouvey, Marc ^c   Challeix, Vincent ^c   Leydier, Antoine ^d   Pellet Rostaing, Stephane ^d   Ansoborlo, Eric ^e   Taran, Frédéric ^a  

^a CEA   (France)

^b CEA DIF   (France)

^c CNRS/LCSB/UMR 7033   (France)

^d UNIVERSITÉ LYON 1   (France)

^e CEA/DEN/DRCP/CETAMA   (France)

Author keywords

Actinide; Chelates; Ligand design; Uranium

Indexed keywords

BISPHOSPHONATE CHELATE URANYL COMPLEX; BISPHOSPHONATE SEQUESTERING AGENT; BISPHOSPHONIC ACID DERIVATIVE; CHELATING AGENT; DIPODAL BISPHOSPHONATE; UNCLASSIFIED DRUG; URANIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CHELATION; CHROMATOPHORE; CONTROLLED STUDY; DRUG BONE LEVEL; DRUG EXCRETION; DRUG LIVER LEVEL; DRUG POTENCY; DRUG RETENTION; DRUG SCREENING; DRUG SYNTHESIS; HEAVY METAL REMOVAL; IN VITRO STUDY; IN VIVO STUDY; KIDNEY TUBULE ABSORPTION; LIGAND BINDING; MALE; NONHUMAN; RAT; SOLUTION PHASE PARALLEL SYNTHESIS; TISSUE DISTRIBUTION; URANIUM CHELATION;

EID: 56949094015     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.01.018     Document Type: Article

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