Patients with Epstein Barr virus-positive lymphomas have decreased CD4 + T-cell responses to the viral nuclear antigen 1

International Journal of Cancer

Volumn 123, Issue 12, 2008, Pages 2824-2831

  Heller, Kevin N ^a   Arrey, Frida ^a   Steinherz, Peter ^b   Portlock, Carol ^b   Chadburn, Amy ^c   Kelly, Kara ^d   Münz, Christian ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c NEW YORK PRESBYTERIAN HOSPITAL   (United States)

^d NewYork Presbyterian Hospital   (United States)

Author keywords

CD4+ T cells; EBNA1; Hodgkin's lymphoma

Indexed keywords

CELL NUCLEUS ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN G4; TETANUS TOXOID; UNCLASSIFIED DRUG; VIRUS ANTIGEN; VIRUS NUCLEAR ANTIGEN 1;

ADOLESCENT; ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; EPSTEIN BARR VIRUS; FEMALE; HODGKIN DISEASE; HUMAN; IMMUNE RESPONSE; IN SITU HYBRIDIZATION; MALE; PRIORITY JOURNAL; SCHOOL CHILD; VIRUS CARRIER;

ADOLESCENT; ADULT; AGED; ANTIGENS, NUCLEAR; ANTIGENS, VIRAL; CARRIER PROTEINS; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CHILD; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HERPESVIRUS 4, HUMAN; HUMANS; IN SITU HYBRIDIZATION; INTERFERON-GAMMA; LYMPHOMA; MALE; MIDDLE AGED; YOUNG ADULT;

EID: 56949087273     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.23845     Document Type: Article

References (28)

1. Kieff E, Rickinson A. Epstein-Barr virus and its replication. In: Knipe DM, Howley PM, eds. Fields virology, 5th edn., vol. 2. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins, 2007:2603-54.
2. Rickinson A, Kieff E. Epstein-Barr virus. In: Knipe DM, Howley PM, eds. Fields virology, vol.2. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins, 2007:2655-700.
3. Gottschalk S, Rooney CM, Heslop HE. Post-transplant lymphoproliferative disorders. Annu Rev Med 2005;56:29-44.
4. Küppers R. B cells under influence: transformation of B cells by Epstein-Barr virus. Nat Rev Immunol 2003;3:801-12.
5. Münz C. Epstein-Barr virus nuclear antigen 1: from immunologically invisible to a promising T cell target. J Exp Med 2004;199:1301-4.
6. + T-cell subsets mediate immune recognition of Epstein Barr virus nuclear antigen 1 in healthy virus carriers. Blood 2007;109:1138-46.
7. Currier JR, Kuta EG, Turk E, Earhart LB, Loomis-Price L, Janetzki S, Ferrari G, Birx DL, Cox JH. A panel of MHC class I restricted viral peptides for use as a quality control for vaccine trial ELISPOT assays. J Immunol Methods 2002;260:157-72.
8. Hanekom WA, Hughes J, Mavinkurve M, Mendillo M, Watkins M, Gamieldien H, Gelderbloem SJ, Sidibana M, Mansoor N, Davids V, Murray RA, Hawkridge A, et al. Novel application of a whole blood intracellular cytokine detection assay to quantitate specific T-cell frequency in field studies. J Immunol Methods 2004;291:185-95.
9. + T lymphocytes consistently respond to the latent Epstein-Barr virus nuclear antigen EBNA1. J Exp Med 2000;191:1649-60.
10. + T-helper 1 responses. J Virol 2001;75:8649-59.
11. + T cells in healthy carriers of Epstein-Barr virus are primarily Th1 in function. J Clin Invest 2001;107:121-30.
12. + T-cell responses to Epstein-Barr virus (EBV) latent-cycle antigens and the recognition of EBV-transformed lymphoblastoid cell lines. J Virol 2005;79:4896-907.
13. Young LS, Rickinson AB. Epstein-Barr virus: 40 years on. Nat Rev Cancer 2004;4:757-68.
14. + T-cell responses directed against Epstein-Barr virus-encoded latent membrane protein 1 and latent membrane protein 2. Int J Cancer 2002;99:93-9.
15. + T cell clones and IL-4 induce IgG4 and IgE switching in purified human B cells via different signaling pathways. J Immunol 1991;147:8-13.
16. Lundgren M, Persson U, Larsson P, Magnusson C, Smith CI, Hammarstrom L, Severinson E. Interleukin 4 induces synthesis of IgE and IgG4 in human B cells. Eur J Immunol 1989;19:1311-15.
17. + T-cell response. Nat Rev Immunol 2004;4:595-602.
18. + T cells: ready for direct attack. J Exp Med 2006;203:805-8.
19. Miller G, Grogan E, Rowe D, Rooney C, Heston L, Eastman R, Andiman W, Niederman J, Lenoir G, Henle W, et al. Selective lack of antibody to a component of EB nuclear antigen in patients with chronic active Epstein-Barr virus infection. J Infect Dis 1987;156:26-35.
20. Hjalgrim H, Askling J, Rostgaard K, Hamilton-Dutoit S, Frisch M, Zhang JS, Madsen M, Rosdahl N, Konradsen HB, Storm HH, Melbye M. Characteristics of Hodgkin's lymphoma after infectious mononucleosis. N Engl J Med 2003;349:1324-32.
21. + T-cell responses provide both helper and cytotoxic functions during Epstein-Barr virus infection and transformation of fetal cord blood B cells. J Virol 2007;81:4766-75.
22. Kapp U, Yeh WC, Patterson B, Elia AJ, Kagi D, Ho A, Hessel A, Tipsword M, Williams A, Mirtsos C, Itie A, Moyle M, et al. Interleukin 13 is secreted by and stimulates the growth of hodgkin and reed-sternberg cells. J Exp Med 1999;189:1939-46.
23. Gandhi MK, Moll G, Smith C, Dua U, Lambley E, Ramuz O, Gill D, Marlton P, Seymour JF, Khanna R. Galectin-1 mediated suppression of Epstein-Barr virus specific T-cell immunity in classic Hodgkin lymphoma. Blood 2007;110:1326-9.
24. Marshall NA, Christie LE, Munro LR, Culligan DJ, Johnston PW, Barker RN, Vickers MA. Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma. Blood 2004;103:1755-62.
25. + T-cell function in Hodgkin lymphoma patients. Blood 2006;108:2280-9.
26. + T cells in HIV-infected patients progressing to AIDS-related non-Hodgkin lymphoma. Blood 2005;106:3166-74.
27. + T cell counts. PLoS Med 2007;4:e96.
28. Piriou ER, van Dort K, Nanlohy NM, Miedema F, van Oers MH, van Baarle D. Altered EBV viral load setpoint after HIV seroconversion is in accordance with lack of predictive value of EBV load for the occurrence of AIDS-related non-Hodgkin lymphoma. J Immunol 2004;172:6931-7.