Inconclusive results in conventional serological screening for Chagas' disease in blood banks: Evaluation of cellular and humoral response

Tropical Medicine and International Health

Volumn 13, Issue 12, 2008, Pages 1527-1533

  Furuchó, Celia Regina ^a   Umezawa, Eufrozina S ^a   Almeida, Igor ^a   Freitas, Vera L ^a   Bezerra, Rita ^a   Nunes, Elisabete V ^b   Sanches, Maria C ^a   Guastini, Cristina M ^a   Teixeira, Antonio R ^c   Shikanai Yasuda, Maria A ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b INSTITUTO ADOLFO LUTZ   (Brazil)

^c UNIVERSITY OF BRASILIA   (Brazil)

Author keywords

Blood bank; Chagas diasease; ELISA; Inconclusive results; Lymphoproliferation; Trypanosoma cruzi

Indexed keywords

PARASITE ANTIBODY; PARASITE ANTIGEN;

BLOOD; CHAGAS DISEASE; DETECTION METHOD; IMMUNOASSAY;

ADULT; AGED; ANTIBODY DETECTION; ARTICLE; BLOOD BANK; CELL ASSAY; CELLULAR IMMUNITY; CHAGAS DISEASE; CHEMOLUMINESCENCE; CHRONIC DISEASE; CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIDEMIOLOGICAL DATA; EPIMASTIGOTE; HEMAGGLUTINATION; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNOASSAY; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; INTERMETHOD COMPARISON; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; PARASITOLOGY; POPULATION RISK; SERODIAGNOSIS; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE EXCRETED SECRETED ANTIGENS BLOT;

TRYPANOSOMA CRUZI;

EID: 56849132605     PISSN: 13602276     EISSN: 13653156     Source Type: Journal    
DOI: 10.1111/j.1365-3156.2008.02172.x     Document Type: Article

References (34)

1. Almeida IC, Covas DT, Soussumi LMT Travassos LR (1997) A highly sensitive and specific chemiluminescent enzyme-linked immunosorbent assay for diagnosis of active Trypanosoma cruzi infection. Transfusion 37, 850 857.
2. Bahia-Oliveira LM, Gomes JA, Cançado JR et al. (2000) Immunological and clinical evaluation in chagasic patients subjected to chemotherapy during the acute phase of Trypanosoma cruzi infection 14-30 years ago. Journal of Infectious Diseases 182, 634 638.
3. Barbosa W, Czerewuta AC Oliveira RL (1983) Tentativa de isolamento primário de pacientes crônicos de doença de Chagas por hemocultura agentes bloqueadores. Revista Patologia Tropical 12, 155 163.
4. Borges-Pereira J, Willcox HPF, Marcondes CB Coura JR (1989) Parasitemia em pacientes chagásicos crônicos avaliada pelo índice de triatomíneos infectados no xenodiagnóstico. Revista da Sociedade Brasileira de Medicina Tropical 22, 39 44.
5. Boyum A (1968) Separation of leukocytes from blood and bone marrow: introduction. Scandinavian Journal of Clinical and Laboratory Investigationl. 97 (Suppl), 77 89.
6. Britto C, Silveira C, Cardoso MA et al. (2001) Parasite persistence in treated chagasic patients revealed by xenodiagnosis and polymerase chain reaction. Memorias do Instituto Oswaldo Cruz 96, 823 826.
7. Burns JMJR, Shreffler WG, Benson DR et al. (1993) Molecular characterization of a kinesin-treated antigen of Leishmania chagasi that detects specific antibody in African and American visceral leishmaniasis. Proceedings of the National Academy of Sciences of the United States of America 90, 775 779.
8. Carmo MS, Santos MR, Cummings LM et al. (2001) Isolation and characterization of genomic and cDNA clones coding for a serine-, alanine-, and proline-rich protein of Trypanosoma cruzi. International Journal for Parasitology 31, 259 264.
9. Carvalho MR, Krieger EA, Oelemann MA et al. (1993) Chagas' disease diagnosis: evaluation of several tests in blood bank screening. Transfusion 33, 830 834.
10. Chang CD, Cheng KY, Jiang LX et al. (2006) Evaluation of a prototype Trypanosoma cruzi antibody assay with recombinant antigens on a fully automated chemiluminescence analyzer for blood donor screening. Transfusion 46, 1737 1744.
11. Cheng KY, Chang CD, Salbilla VA et al. (2007) Immunoblot assay using recombinant antigens as a supplemental test to confirm the presence of antibodies to Trypanosoma cruzi. Clinical and Vaccine Immunology 14, 355 361.
12. Cohen J (1960) A coefficient of agreement for nominal scales. Educational and Psychological Measurement 20, 37 46.
13. Gascon J, Albajar P, Cañas E et al. (2007) Diagnosis, management and treatment of chronic Chagas′ disease heart disease in areas where Trypanosoma cruzi infection is not endemic. Revista Espanola de Cardiologia 60, 285 293.
14. Gomes ML, Galvão LM, Macedo AM, Pena SD Chiari E (1999) Chagas disease diagnosis: comparative analysis of parasitologic, molecular, and serologic methods. American Journal of Tropical Medicine and Hygiene 60, 205 210.
15. Landis JR Koch G (1977) The measurement of observer agreement for categorical data. Biometrics 33, 159 174.
16. Lescure FX, Canestri A, Melliez H et al. (2008) Chagas disease, France. Emerging Infectious Diseases 14, 644 646.
17. Luz LMP, Coutinho MG, Cançado JR Krettli AU (1994) Hemocultura: técnica sensível na detecção do Trypanosoma cruzi em pacientes chagásicos na fase crônica da doença de Chagas. Revista da Sociedade Brasileira de Medicina Tropical 27, 143 148.
18. Martinez EZ, Louzada-Neto F Pereira BB (2003) A curva ROC para testes diagnósticos. Cad Saúde Coletiva 1, 7 31.
19. Ministério da Saúde, Brasil, julho (2008) Oficina de Prioridades de Pesquisa em Doenças Negligenciadas. Published by DECIT: Secretaria de Ciência, Tecnologia e Insumos Estratégicos, Ministério da Saúde, Brasil. Esplanada dos Ministérios, Bloco G, Brasília, Distrito Federal, Brasil, CEP 70 058-900 Available at: http://portal.saude.gov.br/portal/arquivos/pdf/opdn2907.pdf.
20. Pirard M, Iihoshi N, Boelaert M, Basanta P, Lopez F Van der Stuyft P (2005) The validity of serologic tests for Trypanosoma cruzi and the effectiveness of transfusional screening strategies in a hyperendemic region. Transfusion 45, 554 561.
21. Ribeiro-dos-Santos G, Nishiya AS, Sabino EC, Chamone DF Sáez-Alquézar A (1999) An improved, PCR-based strategy for the detection of Trypanosoma cruzi in human blood samples. Annals of Tropical Medicine and Parasitology 93, 689 694.
22. Salles NA, Sabino EC, Cliquet MG et al. (1996) A risk of exposure to Chagas' disease among seroreative Brazilian blood donors. Transfusion 36, 969 973.
23. Salomone OA, Basquiera AL, Sembaj A et al. (2003) Trypanosoma cruzi in persons without serologic evidence of disease, Argentina. Emerging Infectious Diseases 9, 1558 1562.
24. Schmunis GA (2007) Epidemiology of Chagas disease in non-endemic countries: the role of international migration. Memorias do Instituto Oswaldo Cruz 102 (Suppl. I 75 85.
25. Schofield CJ, Jannin J Savatella R (2006) The future of Chagas disease control. Trends in Parasitology 22, 583 588.
26. Senior K (2007) Chagas disease moving towards global elimination. Lancet Infectious Diseases 7, 572.
27. Silveira-Lacerda EP, Silva AG, Junior SF et al. (2004) Chagas' disease: application of TESA blot in inconclusive sera from a Brazilian blood bank. Vox Sanguinis 87, 204 207.
28. Teixeira RL, Macedo V Prata A (1978) Acquired cell-mediated immunodepression in acute Chagas' disease. Journal of Clinical Investigation 62, 1132 1141.
29. Tschudi EL, Anziano DF Dalmasso AP (1972) Lymphocyte transformation in Chagas Disease. Infection and Immunity 6, 906 908.
30. Umezawa EF, Nascimento NS, Kesper NJR et al. (1996) Immunoblot assay using excreted-secreted antigen of Trypanosoma cruzi in serodiagnosis of congenital, acute, and chronic Chagas disease. Journal of Clinical Microbiology 34, 2143 2147.
31. Umezawa ES, Bastos SF, Coura JR et al. (2003) An improved serodiagnostic test for Chagas' disease employing a mixture of Trypanosoma cruzi recombinant antigens. Transfusion 43, 91 97.
32. Wendel S (1998) Transfusion-transmitted Chagas' disease. Current Opinion in Hematology 5, 406 411.
33. WHO (2005) Seventeenth Program Report Progress 2003-2004, WHO, Geneva.
34. Wincker P, Brito C, Pereira JB, Cardoso MA, Oelemann W Morel CM (1994) Use of a simplified polymerase chain reaction procedure to detect Trypanosoma cruzi in blood samples from chronic chagasic patients in a rural endemic area. American Journal of Tropical Medicine and Hygiene 51, 771 777.