Tandem measurement of D-dimer and myeloperoxidase or C-reactive protein to effectively screen for pulmonary embolism in the emergency department

Academic Emergency Medicine

Volumn 15, Issue 9, 2008, Pages 800-805

  Mitchell, Alice M ^a   Nordenholz, Kristen E ^b   Kline, Jeffrey A ^a  

^a CAROLINAS MEDICAL CENTER   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Biological markers; Pulmonary embolism

Indexed keywords

C REACTIVE PROTEIN; D DIMER; MYELOPEROXIDASE;

ADULT; ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DIAGNOSTIC ACCURACY; EMERGENCY WARD; FEMALE; HUMAN; IMAGING SYSTEM; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN ANALYSIS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; VENOUS THROMBOEMBOLISM;

BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; DIAGNOSTIC IMAGING; EMERGENCY SERVICE, HOSPITAL; FEMALE; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; HUMANS; MALE; MIDDLE AGED; PEROXIDASE; PROSPECTIVE STUDIES; PULMONARY EMBOLISM; ROC CURVE; SENSITIVITY AND SPECIFICITY;

EID: 56849114573     PISSN: 10696563     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1553-2712.2008.00204.x     Document Type: Article

References (18)

1. Richman PB, Wood J, Kasper DM, et al. Contribution of indirect computed tomography venography to computed tomography angiography of the chest for the diagnosis of thromboembolic disease in two United States emergency departments. J Thromb Haemost. 2003; 1:652-7.
2. Kalra MK, Maher MM, D'Souza R, Siani S. Multidetector computed tomography technology: current status and emerging developments. J Comput Assist Tomogr. 2004; 28(Suppl 1):S2-S6.
3. Bhargavan M, Sunshine JH. Utilization of radiology services in the United States: levels and trends in modalities, regions, and populations. Radiology. 2005; 234:824-32.
4. Jones AE, Kline JA. Availability of technology to evaluate for pulmonary embolism in academic emergency departments in the United States. J Thromb Haemost. 2003; 1:2240-2.
5. Kline JA, Webb WB, Jones AE, Hernandez-Nino J. Impact of a rapid rule-out protocol for pulmonary embolism on the rate of screening, missed cases, and pulmonary vascular imaging in an urban US emergency department. Ann Emerg Med. 2004; 44:490-502.
6. Kabrhel C, Matts C, McNamara M, Katz J, Ptak T. A highly sensitive ELISA D-dimer increases testing but not diagnosis of pulmonary embolism. Acad Emerg Med. 2006; 13:519-24.
7. Mitchell AM, Kline JA. Contrast nephropathy following computed tomography angiography of the chest for pulmonary embolism in the emergency department. J Thromb Haemost. 2007; 5:50-4.
8. Einstein A, Henzlova M, Rajagopalan S. Estimating risk of cancer associated with radiation exposure from 64-slice computed tomography coronary angiography. JAMA. 2007; 298:317-23.
9. Brenner DJ, Hall EJ, Phil D. Computed tomography-an increasing source of radiation exposure. N Engl J Med. 2007; 357:2277-84.
10. Nordenholz KE, Mitchell AM, Kline JA. Evaluation of fifty potential diagnostic biological markers of pulmonary embolism for use in the emergency department. Acad Emerg Med 2008; in press.
11. Mitchell AM, Kline JA. Systematic bias introduced by the informed consent process in a diagnostic research study. Acad Emerg Med. 2008; 15:225-30.
12. Kline JA, Mitchell AM, Runyon MS, Jones AE, Webb WB. Electronic medical record review as a surrogate to telephone follow-up to establish outcome for diagnostic research studies in the emergency department. Acad Emerg Med. 2005; 12:1127-33.
13. Kline JA, Runyon MS, Webb WB, Jones AE, Mitchell AM. Prospective study of the diagnostic accuracy of the simplify D-dimer assay for pulmonary embolism in emergency department patients. Chest. 2006; 129:1417-23.
14. Nordenholz KE, Zieske M, Dyer DS, Hanson JA, Heard K. Radiologic diagnoses of patients who received imaging for venous thromboembolism despite negative D-dimer tests. Am J Emerg Med. 2007; 25:1040-6.
15. Duriseti RS, Shachter RD, Brandeau ML. Value of quantitative D-dimer assays in identifying pulmonary embolism: implications from a sequential decision model. Acad Emerg Med. 2006; 13:755-66.
16. Bossuyt PM, Reitsma JB, Bruns DE, et al. The STARD statement for reporting studies of diagnostic accuracy: explanation and elaboration. Ann Intern Med. 2003; 138:W1-12.
17. Kline JA, Mitchell A, Kabrhel C, Richman PB, Courtney DM. Reduction of pretest probability below the test threshold using clinical criteria alone [abstract]. Acad Emerg Med. 2004; 11:605-6b.
18. Mitchell AM, Brown MD, Menown IB. Novel protein markers of acute coronary syndrome complications in low-risk outpatients: a systematic review of potential use in the emergency department. Clin Chem. 2005; 51:2005-12.