In vitro evaluation of porous carrier-based floating granular delivery system of orlistat

PDA Journal of Pharmaceutical Science and Technology

Volumn 62, Issue 4, 2008, Pages 292-299

  Jain, Sunil K ^a   Agrawal, G P ^b   Jain, N K ^b  

^a GURU GHASIDAS UNIVERSITY   (India)

^b DR H S GOUR UNIVERSITY   (India)

Author keywords

Calcium silicate; Dissolution models; Floating granules; Orlistat

Indexed keywords

CALCIUM SILICATE; CARBOPOL 940; DRUG CARRIER; ETHYL CELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE; TETRAHYDROLIPSTATIN;

ANGLE OF REPOSE; ARTICLE; BUOYANCY; CONTROLLED DRUG RELEASE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DENSITY; DRUG ABSORPTION; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG DIFFUSION; DRUG GRANULE; DRUG SOLUBILITY; FLOATING GRANULAR DELIVERY SYSTEM; IN VITRO STUDY; PARAMETER; PARTICLE SIZE; POROSITY; SUSTAINED RELEASE FORMULATION;

ACRYLIC RESINS; ALGORITHMS; ANTI-OBESITY AGENTS; CALCIUM COMPOUNDS; CELLULOSE; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; LACTONES; METHYLCELLULOSE; MODELS, BIOLOGICAL; PARTICLE SIZE; POROSITY; REPRODUCIBILITY OF RESULTS; SILICATES; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL;

EID: 56849106152     PISSN: 10797440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Seth, P. R.; Tossounian, J. The hydrodynamically balanced system (HBS™): a novel drug delivery system for oral use. Drug Dev. Ind. Pharm. 1984, 10, 313-339.
2. Moes, A. J. Floating delivery and other potential gastric retaining systems, Current status on targeted drug delivery to the gastrointestinal tract. Capsugel Library 1993, 34 97-112.
3. Deshpande, A.; Rhodes, C. T.; Shah, N. H.; Malick, A. W. Controlled-release drug delivery systems for prolonged gastric residence: an overview. Drug Dev. Ind. Pharm. 1996, 22, 531-539.
4. Dennis, A.; Timmins, P.; Lee, K. Buoyant Controlled Release Powder Formulation. U.S. Patent 5,169,638, 1992.
5. Shimpi, S.; Chauhan, B.; Mahadik, K. R.; Paradkar, A. Preparation and evaluation of diltiazem hydrochloride-gelucire 43/01 floating granules prepared by melt granulation. AAPS Pharm-SciTech. 2004, 5 (3), Article 43.
6. Jain, S. K.; Awasthi, A. M.; Jain, N. K.; Agrawal, G. P. Calcium silicate based microspheres of repaglinide for gastro-retentive floating drug delivery: Preparation and in vitro characterization. J. Controlled Release 2005, 107, 300-309.
7. Jain, S. K.; Agrawal, G. P.; Jain, N. K. A novel calcium silicate based microspheres of repaglinide: in vivo investigations. J. Controlled Release 2006, 113, 111-116.
8. Jain, A. K.; Jain, S. K.; Yadav, A.; Agrawal, G. P. Controlled release calcium silicate based floating granular delivery system of ranitidine hydrochloride. Curr. Drug Del. 2006, 3 (4), 367-372.
9. Yuasa, H.; Takashima, Y.; Kanaya, Y. Studies on the development of intragastric floating and sustained release preparation. I. Application of calcium silicate as a floating carrier. Chem. Pharm. Bull. 1996, 44, 1361-1366.
10. Keating, G. M.; Jarvis, B. Orlistat. Drugs 2001, 61 (14), 2107-2119.
11. Jain, S. K.; Agrawal, G. P.; Jain, N. K. Porous carrier based floating granular delivery system of repaglinide. Drug Dev. Ind. Pharm. 2007, 33, 381-391.
12. Dortunc, B.; Gunal, N. Release of acetazolamide from swellable hydroxypropyl methylcellulose matrix tablets. Drug Dev. Ind. Pharm. 1997, 23, 1245-1249.
13. Wan, L. S.; Heng, P. W.; Wong, L. F. Matrix swelling: simple model describing extent of swelling of HPMC matrix. Int. J. Pharm. 1995, 116, 159-168.
14. Desai, S.; Bolton, S. A floating controlled-release drug delivery systems: in vitro-in vivo evaluation. Pharm. Res. 1993, 10, 1321-1325.
15. Khatter, D.; Ahuja, A.; Khar, R. K. Hydrodynamically balanced systems as sustained release dosage forms for propranolol hydrochloride. Pharmazie 1990, 45, 356-358.