Leukemia inhibitory factor contributes to hepatocyte-like differentiation of human bone marrow mesenchymal stem cells

Differentiation

Volumn 76, Issue 10, 2008, Pages 1057-1067

  Lysy, Philippe A ^a   Smets, Françoise ^a   Najimi, Mustapha ^a   Sokal, Etienne M ^a  

^a CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

Author keywords

Hepatocyte differentiation; Leukemia inhibitory factor; Mesenchymal stem cells; Oncostatin M

Indexed keywords

GLYCOGEN; LEUKEMIA INHIBITORY FACTOR; ONCOSTATIN M; UREA;

ADULT; ARTICLE; BIOASSAY; BONE MARROW; CELL DIFFERENTIATION; CELL MATURATION; CELL STRUCTURE; CONTROLLED STUDY; GENE EXPRESSION; GLYCOGEN SYNTHESIS; HUMAN; HUMAN CELL; LIVER CELL; MESENCHYMAL STEM CELL; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; UREA CYCLE;

EID: 56749185842     PISSN: 03014681     EISSN: 14320436     Source Type: Journal    
DOI: 10.1111/j.1432-0436.2008.00287.x     Document Type: Article

References (26)

1. Aurich, I., Mueller, L.P., Aurich, H., Luetzkendorf, J., Tisljar, K., Dollinger, M., Schormann, W., Walldorf, J., Hengstler, J., Fleig, W.E. Christ, B. (2007) Functional integration of human mesenchymal stem cell-derived hepatocytes into mouse livers. Gut 56 : 405 415. Epub 2006 Aug 23.
2. Campard, D., Lysy, P.A., Najimi, M. Sokal, E.M. (2008) Native umbilical cord matrix stem cells express hepatic markers and differentiate into hepatocyte-like cells. Gastroenterology 134 : 833 848. Epub 2007 Dec 23.
3. Cho, C.H., Parashurama, N., Park, E.Y., Suganuma, K., Nahmias, Y., Park, J., Tilles, A.W., Berthiaume, F. Yarmush, M.L. (2007) Homogeneous differentiation of hepatocyte-like cells from embryonic stem cells: applications for the treatment of liver failure. FASEB J 22 : 898 909. Epub 2007 Oct 17.
4. Donato, M.T., Gomez-Lechon, M.J., Jover, R., Nakamura, T. Castell, J.V. (1998) Human hepatocyte growth factor down-regulates the expression of cytochrome P450 isozymes in human hepatocytes in primary culture. J Pharmacol Exp Ther 284 : 760 767.
5. Escary, J.L., Perreau, J., Dumenil, D., Ezine, S. Brulet, P. (1993) Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation. Nature 363 : 361 364.
6. Falconi, D., Oizumi, K. Aubin, J.E. (2007) Leukemia inhibitory factor influences the fate choice of mesenchymal progenitor cells. Stem Cells 25 : 305 312.
7. Guillen, M.I., Donato, M.T., Jover, R., Castell, J.V., Fabra, R., Trullenque, R. Gomez-Lechon, M.J. (1998) Oncostatin M down-regulates basal and induced cytochromes P450 in human hepatocytes. J Pharmacol Exp Ther 285 : 127 134.
8. Heinrich, P.C., Behrmann, I., Haan, S., Hermanns, H.M., Muller-Newen, G. Schaper, F. (2003) Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J 374 : 1 20.
9. Hengstler, J.G., Brulport, M., Schormann, W., Bauer, A., Hermes, M., Nussler, A.K., Fandrich, F., Ruhnke, M., Ungefroren, H., Griffin, L., Bockamp, E., Oesch, F. von Mach, M.A. (2005) Generation of human hepatocytes by stem cell technology: definition of the hepatocyte. Expert Opin Drug Metab Toxicol 1 : 61 74.
10. Hong, S.H., Gang, E.J., Jeong, J.A., Ahn, C., Hwang, S.H., Yang, I.H., Park, H.K., Han, H. Kim, H. (2005) In vitro differentiation of human umbilical cord blood-derived mesenchymal stem cells into hepatocyte-like cells. Biochem Biophys Res Commun 330 : 1153 1161.
11. Jiang, Y., Vaessen, B., Lenvik, T., Blackstad, M., Reyes, M. Verfaillie, C.M. (2002) Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain. Exp Hematol 30 : 896 904.
12. Kamiya, A., Kojima, N., Kinoshita, T., Sakai, Y. Miyaijma, A. (2002) Maturation of fetal hepatocytes in vitro by extracellular matrices and oncostatin M: induction of tryptophan oxygenase. Hepatology 35 : 1351 1359.
13. Kinoshita, T., Sekiguchi, T., Xu, M.J., Ito, Y., Kamiya, A., Tsuji, K., Nakahata, T. Miyajima, A. (1999) Hepatic differentiation induced by oncostatin M attenuates fetal liver hematopoiesis. Proc Natl Acad Sci USA 96 : 7265 7270.
14. Lee, K.D., Kuo, T.K., Whang-Peng, J., Chung, Y.F., Lin, C.T., Chou, S.H., Chen, J.R., Chen, Y.P. Lee, O.K. (2004) In vitro hepatic differentiation of human mesenchymal stem cells. Hepatology 40 : 1275 1284.
15. Lysy, P.A., Campard, D., Smets, F., Malaise, J., Mourad, M., Najimi, M. Sokal, E.M. (2008) Persistence of a chimerical phenotype after hepatocyte differentiation of human bone marrow mesenchymal stem cells. Cell Prolif 41 : 36 58.
16. Metcalf, D. (2003) The unsolved enigmas of leukemia inhibitory factor. Stem Cells 21 : 5 14.
17. Morikawa, Y. (2005) Oncostatin M in the development of the nervous system. Anat Sci Int 80 : 53 59.
18. Nakashima, K. Taga, T. (1998) gp130 and the IL-6 family of cytokines: signaling mechanisms and thrombopoietic activities. Semin Hematol 35 : 210 221.
19. Nussler, A., Konig, S., Ott, M., Sokal, E., Christ, B., Thasler, W., Brulport, M., Gabelein, G., Schormann, W., Schulze, M., Ellis, E., Kraemer, M., Nocken, F., Fleig, W., Manns, M., Strom, S.C. Hengstler, J.G. (2006) Present status and perspectives of cell-based therapies for liver diseases. J Hepatol 45 : 144 159.
20. 4-injured rats. J Hepatol 44 : 742 748.
21. Seo, M.J., Suh, S.Y., Bae, Y.C. Jung, J.S. (2005) Differentiation of human adipose stromal cells into hepatic lineage in vitro and in vivo. Biochem Biophys Res Commun 328 : 258 264.
22. Suzuki, A., Iwama, A., Miyashita, H., Nakauchi, H. Taniguchi, H. (2003) Role for growth factors and extracellular matrix in controlling differentiation of prospectively isolated hepatic stem cells. Development 130 : 2513 2524.
23. Tanaka, M. Miyajima, A. (2003) Oncostatin M, a multifunctional cytokine. Rev Physiol Biochem Pharmacol 149 : 39 52.
24. Teratani, T., Yamamoto, H., Aoyagi, K., Sasaki, H., Asari, A., Quinn, G., Sasaki, H., Terada, M. Ochiya, T. (2005) Direct hepatic fate specification from mouse embryonic stem cells. Hepatology 41 : 836 846.
25. Wang, P.P., Wang, J.H., Yan, Z.P., Hu, M.Y., Lau, G.K., Fan, S.T. Luk, J.M. (2004) Expression of hepatocyte-like phenotypes in bone marrow stromal cells after HGF induction. Biochem Biophys Res Commun 320 : 712 716.
26. Zhang, Y., Willson, T., Metcalf, D., Cary, D., Hilton, D.J., Clark, R. Nicola, N.A. (1998) The box-1 region of the leukemia inhibitory factor receptor alpha-chain cytoplasmic domain is sufficient for hemopoietic cell proliferation and differentiation. J Biol Chem 273 : 34370 34383.