Polyurethane scaffold formation via a combination of salt leaching and thermally induced phase separation

Journal of Biomedical Materials Research - Part A

Volumn 87, Issue 4, 2008, Pages 921-932

  Heijkants, R G J C ^a   Van Calck, R V ^a   Van Tienen, T G ^b   De Groot, J H ^a   Pennings, A J ^b   Buma, P ^b   Veth, R P H ^b   Schouten, A J ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Degradable; Meniscus; Polyurethane; Scaffold; Thermally induced phase separation

Indexed keywords

ABS RESINS; BIOLOGICAL MEMBRANES; DISSOLUTION; ISOMERS; LEACHING; PHASE MODULATION; POLYMERS; POROSITY; SCAFFOLDS; SEPARATION; TOXIC MATERIALS;

COMPRESSION MODULUS; DEGRADABLE; INTERCONNECTIVITY; MEDICAL ASPECTS; MENISCUS; POLYURETHANE SCAFFOLDS; POROUS FOAMS; POROUS SCAFFOLDS; PRODUCTION PROCESSES; SALT LEACHING; SEPARATION OF POLYMERS; THERMALLY INDUCED PHASE SEPARATION;

PHASE SEPARATION;

DIMETHYL SULFOXIDE; POLYURETHAN; SODIUM CHLORIDE; WATER;

ARTICLE; COMPRESSION; COOLING; FOAM; LEACHING; MOLECULAR WEIGHT; PHASE SEPARATION; POROSITY; ROOM TEMPERATURE;

ANIMALS; BIOCOMPATIBLE MATERIALS; DIMETHYL SULFOXIDE; MATERIALS TESTING; POLYURETHANES; POROSITY; SALTS; SOLVENTS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SURFACE PROPERTIES; TEMPERATURE; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 56749177099     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.31829     Document Type: Article

References (42)

1. Hou Q, Grijpma DW, Feijen J. Porous polymeric structures for tissue engineering prepared by a coagulation, compression moulding and salt leaching technique. Biomaterials 2003;24:1937-1947.
2. Hou Q, Grijpma DW, Feijen J. Preparation of porous poly(ε- caprolactone) structures. Macromol Rapid Commun 2002;23: 247-252.
3. Chen G, Ushida T, Tateishi T. Preparation of poly(L-lactic acid) and poly(DL-lactic-co-glycolic acid) foams by use of ice microparticulates. Biomaterials 2001;22:2563-2567.
4. Nam YS, Yoon JJ, Park TG. A novel fabrication method of macroporous biodegradable polymer scaffolds using gas foaming salt as a porogen additive. J Biomed Mater Res B 2000;53:1-7.
5. Spaans CJ, de Groot JH, Belgraver VW, Pennings AJ. A new biomedical polyurethane with a high modulus based on 1,4-butanediisocyanate and ε-caprolactone. J Mater Sci: Mater Med 1998;9:675-678.
6. Hutmacher DW, Schantz T, Zein I, Ng KW, Teoh SH, Tan KC. Mechanical properties and cell cultural response of polycaprolactone scaffolds designed and fabricated via fused deposition modeling. J Biomed Mater Res 2000;55:203-216.
7. Hua FJ, Kim GE, Lee JD, Son YK, Lee DS. Macroporous poly(L- lactide) scaffold 1. Preparation of a macroporous scaffold by liquid-liquid phase separation of a PLLA-dioxane-water system. J Biomed Mater Res B 2002;63:161-167.
8. Nam YS, Park TG. Biodegradable polymeric microcellular foams by modified thermally induced phase separation method. Biomaterials 1999;20:1783-1790.
9. van de Witte P, Esselbrugge H, Dijkstra PJ, van den Berg JWA, Feijen J. Phase transitions during membrane formation of polylactides. I. A morphological study of membranes obtained from the system polylactide-chloroform-methanol. J Membr Sci 1996;113:223-236.
10. Guan J, Fuijmoto K, Sacks M, Wagner W. Preparation and characterization of highly porous, biodegradable polyurethane scaffolds for soft tissue applications. Biomaterials 2006;26:3961-3971.
11. Stankus J, Guan J, Wagner W. Fabrication of biodegradable elastomeric scaffolds with sub-micron morphologies. J Biomed Mater Res A 2004;70:603-614.
12. Murphy WL, Dennis RG, Kileny JL, Mooney DJ. Salt fusion: An approach to improve pore interconnectivity within tissue engineering scaffolds. Tissue Eng 2002;8:43-52.
13. Elema H, De Groot JH, Nijenhuis AJ, Pennings AJ, Veth RPH, Klompmaker J, Jansen HWB. Use of biodegradable polymer implants in meniscus reconstruction. II. Biological evaluation of porous biodegradable implants in menisci. Colloid Polym Sci 1990;268:1082-1088.
14. Klompmaker J, Jansen HWB, Veth RP, Nielsen HKL, De Groot JH, Pennings AJ. Porous implants for knee joint meniscus reconstruction: A preliminary study on the role of pore sizes in ingrowth and differentiation of fibrocartilage. Clin Mater 1993;14:1-11.
15. Taylor DF, Smith FB. Porous methyl methacrylate as an implant material. J Biomed Mater Res Symp 1972;2:467-479.
16. Hulbert SF, Young FA, Mathews RS, Klawitter JJ, Talbert CD, Stelling FH. Potential of ceramic materials as premanently implantable skeletal prostheses. J Biomed Mater Res 1970; 4:433-456.
17. Taylor DF, Smith FB. Porous methyl methacrylate as an implant material. J Biomed Mater Res 1983;17:205-227.
18. Vacanti JP, Morse MA, Saltzmann WM, Domb AJ, Perez-Atayde A, Langer R. Selective cell transplantation using bioabsorbable artificial polymers as matrices. J Pediatr Surg 1988; 23:3-9.
19. Wake MC, Mikos AG, Sarakinos G, Vacanti JP, Langer R. Dynamics of fibrovascular tissue ingrowth in hydrogel foams. Cell Transplant 1995;4:275-279.
20. Klompmaker J, Jansen HWB, Veth RPH, de Groot JH, Pennings AJ, Kuijer R. Porous polymer implants for repair of meniscal lesions: A preliminary study in dogs. Biomaterials 1992;12:810-816.
21. Gorna K, Gogolewski S. Biodegradable porous polyurethane scaffolds for tissue repair and regeneration. J Biomed Mater Res A 2006;79:128-138.
22. De Groot JH, De Vrijer R, Pennings AJ, Klopmaker J, Veth RPH, Jansen HWB. Use of porous polyurethanes of meniscal reconstruction and meniscsal prosthesis. Biomaterials 1996;17: 163-173.
23. de Groot JH, Pennings AJ, Spaans CS, Wildeboer BS, de Vrijer R. New biomedical polyurethane ureas with high tear strengths. Polym Bull 1997;38:211-218.
24. van Tienen TG, Heijkants RGJC, Buma P, de Groot JH, Pennings AJ, Veth RPH. Tissue ingrowth and degradation of two biodegradable porous polymers with different porosities and poresizes. Biomaterials 2002;23:1731-1738.
25. van Tienen TG, Heijkants RGJC, Buma P, de Groot JH, Pennings AJ, Veth RPH. A porous polymer scaffold for meniscal lesion repair - A study in dogs. Biomaterials 2003;24:2541-2548.
26. Heijkants RGJC, van Calck RV, de Groot JH, Buma P, Pennings AJ, Veth RPH, Schouten AJ. Uncatalyzed synthesis, thermal and mechanical properties of polyurethanes based on poly(ε-caprolactone) and 1,4-butane diisocyanate with uniform hard segment. Biomaterials 2005;26:4219-4228.
27. Ramrattan NN, Heijkants RGJC, van Tienen TG, Schouten AJ, Veth RPH, Buma P. Assessment of tissue ingrowth rates in polyurethane scaffolds for tissue engineering. Tissue Eng 2005;11:1212-1223.
28. van Tienen TG, Heijkants RGJC, de Groot JH, Pennings AJ, Schouten AJ, Veth RPH, Buma P. Replacement of the knee meniscus by a porous polymer implant. Am J Sports Med 2006;34:64.
29. Heijkants RGJC, van Calck RV, van Tienen TG, Ramrattan N, Buma P, de Groot JH, Pennings AJ, Veth RPH, Schouten AJ. Design, synthesis and properties of a degradable polyurethane scaffold for meniscus regeneration. J Mater Sci: Mater Med 2004;15:423-427.
30. Heijkants RGJC, van Calck RV, de Groot JH, Pennings AJ, Schouten AJ. Phase transitions in segmented polyesterurethane-DMSO-water systems. J Polym Sci Part B: Polym Phys 2005;43:716-723.
31. Goris A. Test of the toxicity of dimethylsulfoxide (DMSO) on carrot tissue cultured in vitro. Ann Pharm Fr 1968;24:781-785.
32. Goris RJ. Treatment of reflex sympathetic dystrophy with hydroxyl radical scavengers. Unfallchirurgie 1985;88:330-332.
33. Rasmussen DH, MacKenzie AP. Phase diagram for the system water-dimethylsulphoxide. Nature 1968;220:1315-1317.
34. Arnauts J, De Cooman R, Vandeweerdt P, Koningsveld R, Berghmans H. Calorimetric analysis of liquid-liquid phase separation. Thermochim Acta 1994;238:1-16.
35. De Groot JH, Nijenhuis AJ, Bruin P, Pennings AJ, Veth RPH, Klompmaker J, Jansen HWB. Use of porous biodegradable polymer implants in meniscus reconstruction. I. Preparation of meniscus lesions. Colloid Polym Sci 1990;268: 1071-1081.
36. Crescenzi V, Manzini G, Calzolari G, Borri C. Thermodynamics of fusion of poly-β-propiolactone and poly-ε-caprolactone. Comparative analysis of the melting of aliphatic polylactone and polyester chains. Eur Polym J 1972;8:449-463.
37. van de Witte P, Dijkstra PJ, van den Berg JWA, Feijen J. Phase separation processes in polymer solutions in relation to membrane formation. J Membr Sci 1996;117:1-31.
38. Walheim S, Ramstein M, Steiner U. Morphologies in ternary polymer blends after spin coating. Langmuir 1999;15:4828-4836.
39. de Groot JH, Zijlstra FM, Kuipers HW, Pennings AJ, Klompmaker J, Veth RPH, Jansen HWB. Meniscal tissue regeneration in porous 50/50 copoly(L-lactide/ε-caprolactone) implants. Biomaterials 1997;18:613-622.
40. Klompmaker J. Porous polymers for the repair and replacement of knee joint meniscus and articular cartilage, Doctoral Thesis, University of Nijmegen, 1992, Chapter 6.
41. Heijkants RGJC, van Tienen TG, de Groot JH, Pennings AJ, Buma P, Veth RPH, Schouten AJ. Preparation of a polyurethane scaffold for tissue engineering made by a combination of salt leaching and freeze-drying of dioxane. J Mater Sci 2006;41:2423.
42. Gibson LJ, Ashby MF. Cellular Solids, Structure and Properties. Oxford: Pergamon Press; 1988. p 122-153.