A polymorphism in the gene encoding the Fcγ IIIA receptor is a possible genetic marker to predict the primary response to infliximab in Japanese patients with rheumatoid arthritis

Annals of the Rheumatic Diseases

Volumn 67, Issue 12, 2008, Pages 1791-1792

  Tsukahara, S ^a   Ikari, Katsunori ^a   Sato, E ^a   Yamanaka, H ^a   Hara, M ^a   Tomatsu, T ^a   Momohara, S ^a   Kamatani, N ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD16 ANTIGEN; FC GAMMA R III A; INFLIXIMAB; UNCLASSIFIED DRUG;

ADULT; CLINICAL ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; DNA POLYMORPHISM; FEMALE; GENOTYPE; HUMAN; JAPAN; LETTER; MALE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; TREATMENT RESPONSE;

ADULT; ANTIBODIES, MONOCLONAL; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; FEMALE; GENETIC MARKERS; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RECEPTORS, IGG; TREATMENT OUTCOME;

EID: 56749168819     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/ard.2007.086892     Document Type: Letter

References (4)

1. Tutuncu Z, Kavanaugh A, Zvaifler N, Corr M, Deutsch R, Boyle D. Fcgamma receptor type IIIA polymorphisms influence treatment outcomes in patients with inflammatory arthritis treated with tumor necrosis factor alpha-blocking agents. Arthritis Rheum 2005;52:2693-6.
2. Wu J, Edberg JC, Redecha PB, Bansal V, Guyre PM, Coleman K, et al. A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease. J Clin Invest 1997;100:1059- 70.
3. Kastbom A, Bratt J, Ernestam S, Lampa J, Padyukov L, Soderkvist P, et al. Fcgamma receptor type IIIA genotype and response to tumor necrosis factor alpha-blocking agents in patients with rheumatoid arthritis. Arthritis Rheum 2007;56:448-52.
4. Louis EJ, Watier HE, Schreiber S, Hampe J, Taillard F, Olson A, et al. Polymorphism in IgG Fc receptor gene FCGR3A and response to infliximab in Crohn's disease: a subanalysis of the ACCENT I study. Pharmacogenet Genomics 2006;16:911-14.