Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding

Protein Science

Volumn 17, Issue 12, 2008, Pages 2127-2133

  Pearce, Mary C ^a   Morton, Craig J ^b   Feil, Susanne C ^b,c   Hansen, Guido ^b   Adams, Julian J ^b,d   Parker, Michael W ^b,c   Bottomley, Stephen P ^a  

^a MONASH UNIVERSITY   (Australia)

^b ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d AUSTRALIAN SYNCHROTRON   (Australia)

Author keywords

Antitrypsin; Polymerization; Protein aggregation; Protein unfolding; Serpin

Indexed keywords

CITRIC ACID; SERINE PROTEINASE INHIBITOR; SERPIN DERIVATIVE; TRYPSIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BETA SHEET; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; EMPHYSEMA; INBORN ERROR OF METABOLISM; LIVER CIRRHOSIS; MOLECULAR MECHANICS; NEWBORN HEPATITIS; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN STABILITY; SERINOPATHY;

ALPHA 1-ANTITRYPSIN; BINDING SITES; BIOPOLYMERS; CITRIC ACID; CRYSTALLOGRAPHY, X-RAY; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY;

EID: 56749166164     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1110/ps.037234.108     Document Type: Article

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