Highly sensitive and rapid LC-ESI-MS/MS method for the simultaneous quantification of uroselective α1-blocker, alfuzosin and an antimuscarinic agent, solifenacin in human plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 876, Issue 2, 2008, Pages 236-244

  Mistri, Hiren N ^a,b   Jangid, Arvind G ^b   Pudage, Ashutosh ^b   Rathod, Dhiraj M ^b   Shrivastav, Pranav S ^a  

^a GUJARAT UNIVERSITY   (India)

^b Accutest Research Laboratories I Pvt Ltd   (India)

Author keywords

Alfuzosin; Bioavailability study; LC ESI MS MS; Liquid liquid extraction; Solifenacin

Indexed keywords

BIOCHEMISTRY; CONCENTRATION (PROCESS); CUSTOMER SATISFACTION; ETHERS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MAGNESIUM PRINTING PLATES; MASS SPECTROMETRY; ORGANIC COMPOUNDS; PLASMA (HUMAN); PLASMA STABILITY; PLASMAS; QUALITY ASSURANCE; QUALITY CONTROL; QUALITY FUNCTION DEPLOYMENT; SOLVENT EXTRACTION; THEOREM PROVING; TOTAL QUALITY MANAGEMENT;

ACCURACY AND PRECISIONS; ALFUZOSIN; ANALYTES; BIO AVAILABILITIES; BIOANALYTICAL METHODS; BIOAVAILABILITY STUDY; BUTYL ETHERS; CONCENTRATION RANGES; HIGHLY SENSITIVES; HUMAN PLASMAS; INTERNAL STANDARDS; LC-ESI-MS/MS; LINEAR CALIBRATION CURVES; ORAL ADMINISTRATIONS; PLASMA SAMPLES; RUN TIMES; SOLIFENACIN; STORAGE CONDITIONS; TABLET FORMULATIONS; TANDEM MASS SPECTROMETRIES; TURBO ION SPRAYS; VALIDATED METHODS;

EXTRACTION;

ALFUZOSIN; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; MUSCARINIC RECEPTOR BLOCKING AGENT; PROPRANOLOL; SOLIFENACIN;

ACCURACY; ANALYTIC METHOD; ARTICLE; BLOOD SAMPLING; CALIBRATION; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STABILITY; DRUG STORAGE; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; LIQUID CHROMATOGRAPHY; NORMAL HUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; SINGLE DRUG DOSE; TABLET FORMULATION; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

ADRENERGIC ALPHA-ANTAGONISTS; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; HUMANS; MALE; METHYL ETHERS; MUSCARINIC ANTAGONISTS; PROPRANOLOL; QUINAZOLINES; QUINUCLIDINES; REFERENCE STANDARDS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; TETRAHYDROISOQUINOLINES;

EID: 56749163204     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.10.050     Document Type: Article

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