Rapidly fatal clozapine-induced intestinal obstruction without prior warning signs

Australian and New Zealand Journal of Psychiatry

Volumn 42, Issue 12, 2008, Pages 1073-1074

  Yan Leung, Joey Shuk ^a   Lee, Chi Chiu ^a   Lee, Wing King ^a   Keung Kwong, Patrick Po ^a  

^a KWAI CHUNG HOSPITAL   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

CLOZAPINE; DIAZEPAM; VALPROIC ACID; ZIPRASIDONE;

ABDOMINAL DISTENSION; ADULT; AUTOPSY; CASE REPORT; CAUSE OF DEATH; CONSTIPATION; DRUG DOSE TITRATION; FECES IMPACTION; FEMALE; HUMAN; HUMAN TISSUE; INTESTINE OBSTRUCTION; LETTER; LUNG EDEMA; MALE; MENTAL HEALTH; SCHIZOPHRENIA; URINE INCONTINENCE; VOMITING;

ADULT; ANTIPSYCHOTIC AGENTS; CLOZAPINE; COLON; COLONIC DISEASES; DRUG THERAPY, COMBINATION; FATAL OUTCOME; FECAL IMPACTION; FEMALE; HUMANS; INTESTINAL OBSTRUCTION; LUNG; MALE; MIDDLE AGED; RECTAL DISEASES; RECTUM; RESPIRATORY ASPIRATION; SCHIZOPHRENIA;

EID: 56749149772     PISSN: 00048674     EISSN: 14401614     Source Type: Journal    
DOI: 10.1080/00048670802512081     Document Type: Letter

References (4)

1. Hayes, G. and Gibler, B. (1995) Clozapine-induced constipation. Am J Psychiatry, 152, p. 298.
2. Palmer, SE, McLean, RM, Ellis, PM and Harrison-Woolrych, M. (2008) Life-threatening clozapine-induced gastrointestinal hypomotility: An analysis of 102 cases. J Clin Psychiatry, 69, pp. 759-768.
3. Drew, L. and Herdson, P. (1997) Clozapine and constipation: A serious issue. Aust N Z J Psychiatry, 31, pp. 149-150.
4. Bickerstaff, LK, Harris, SC, Leggett, RS and Cheah, KC. (1988) Pain insensitivity in schizophrenic patients. A surgical dilemma. Arch Surg., 123, pp. 49-51.