Mass spectrometry signal amplification method for attomolar detection of antigens using small-molecule-tagged gold microparticles

Angewandte Chemie - International Edition

Volumn 47, Issue 49, 2008, Pages 9518-9521

  Lee, Jung Rok ^c   Lee, Juhee ^b   Kim, Sang Kyung ^d   Kim, Kwang Pyo ^c   Park, Hyung Soon ^a   Yeo, Woon Seok ^b  

^a Probiond Co Ltd   (South Korea)

^b Konkuk University   (South Korea)

^c Konkuk University   (South Korea)

^d Korea Institute of Science and Technology   (South Korea)

Author keywords

Gold; Mass spectrometry; Monolayers; Proteins; Signal amplification

Indexed keywords

DESORPTION; ELECTRON ENERGY LEVELS; GOLD; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; PROTEINS; SELF ASSEMBLED MONOLAYERS; SIGNAL PROCESSING; SPECTROMETERS; SPECTROMETRY; SPECTRUM ANALYSIS;

ATTOMOLAR DETECTIONS; DETECTION LIMITS; LABELING STEPS; LASER DESORPTION/IONIZATION; MICRO PARTICLES; SIGNAL AMPLIFICATION; SIGNAL AMPLIFICATIONS; SMALL MOLECULES; TIME OF FLIGHTS; ULTRA HIGH SENSITIVITIES;

AMPLIFICATION;

ANTIGEN; GOLD;

ARTICLE; CHEMISTRY; MASS SPECTROMETRY; METHODOLOGY; PARTICLE SIZE;

ANTIGENS; GOLD; PARTICLE SIZE; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 56749115946     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200803893     Document Type: Article

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