Combined local and systemic methotrexate treatment of viable ectopic pregnancy: Outcomes of 31 cases

Journal of Clinical Ultrasound

Volumn 36, Issue 9, 2008, Pages 545-550

  Smorgick, Noam ^a   Vaknin, Zvi ^a   Pansky, Moti ^a   Halperin, Reuvit ^a   Herman, Arie ^a   Maymon, Ron ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Methotrexate; Ultrasound; Viable ectopic pregnancy

Indexed keywords

CHORIONIC GONADOTROPIN BETA SUBUNIT; METHOTREXATE;

ADULT; ARTICLE; CESAREAN SECTION; CLINICAL ARTICLE; CONTROLLED STUDY; DOPPLER ECHOGRAPHY; DRUG EFFICACY; ECTOPIC PREGNANCY; FEMALE; HUMAN; PREGNANCY OUTCOME; TREATMENT OUTCOME;

ADULT; DRUG ADMINISTRATION ROUTES; FEMALE; HUMANS; METHOTREXATE; NUCLEIC ACID SYNTHESIS INHIBITORS; PREGNANCY; PREGNANCY, ECTOPIC; RETROSPECTIVE STUDIES; TREATMENT OUTCOME; YOUNG ADULT;

EID: 56749105558     PISSN: 00912751     EISSN: 10970096     Source Type: Journal    
DOI: 10.1002/jcu.20506     Document Type: Article

References (21)

1. Cacciatore B, Stenman UH, Ylostalo P. Diagnosis of ectopic pregnancy by vaginal ultrasonography in combination with a discriminatory serum hCG level of 1000 IU/l. Br J Obstet Gynaecol 1990;97:904.
2. Condous G, Okaro E, Khalid A, et al. The accuracy of transvaginal ultrasonography for the diagnosis of ectopic pregnancy prior to surgery. Hum Reprod 2005;20:1404.
3. Stovall TG, Ling FW, Carson SA, et al. Non-surgical diagnosis and treatment of tubal pregnancy. Fertil Steril 1990;54:537.
4. Lipscomb GH, McCord ML, Stovall TG, et al. Predictors of success of methotrexate treatment in women with tubal ectopic pregnancies. N Engl J Med 1999;341:1974.
5. Kirk E, Condous G, Bourne T. The non-surgical management of ectopic pregnancy. Ultrasound Obstet Gynecol 2006;27:91.
6. Halperin R, Vaknin Z, Schneider D, et al. Management of ectopic pregnancy with fetal cardiac activity by combined local (sonographically guided) and systemic injection of methotrexate. Gynecol Obstet Invest 2003;56:148.
7. Timor-Tritsch IE, Monteagudo A, Materna C, et al. Sonographic evolution of cornual pregnancies treated without surgery. Obstet Gynecol 1992;79:1044.
8. Maymon R, Halperin R, Mendlovic S, et al. Ectopic pregnancies in Caesarean section scars: the 8 year experience of one medical centre. Hum Reprod 2004;19:278.
9. Doubilet PM, Benson CB, Frates MC, et al. Sonographically guided minimally invasive treatment of unusual ectopic pregnancies. J Ultrasound Med 2004;23:359.
10. Monteagudo A, Minior VK, Stephenson C, et al. Non-surgical management of live ectopic pregnancy with ultrasound-guided local injection: a case series. Ultrasound Obstet Gynecol 2005;25:282.
11. Shufaro Y, Nadjari M. Implantation of a gestational sac in a cesarean section scar. Fertil Steril 2001; 75:1217.
12. Seow KM, Huang LW, Lin YH, et al. Cesarean scar pregnancy: issues in management. Ultrasound Obstet Gynecol 2004;23:247.
13. Timor-Tritsch IE, Monteagudo A, Lerner JP. A "potentially safer" route for puncture and injection of cornual ectopic pregnancies. Ultrasound Obstet Gynecol 1996;7:353.
14. Pansky M, Bukovsky I, Golan A, et al. Conservative management of interstitial pregnancy using operative laparoscopy. Surg Endosc 1995;9:515.
15. Jermy K, Thomas J, Doo A, et al. The conservative management of interstitial pregnancy. Br J Obstet Gynaecol 2004;111:1283.
16. Fernandez H, Benifla JL, Lelaidier C, et al. Methotrexate treatment of ectopic pregnancy: 100 cases treated by primary transvaginal injection under sonographic control. Fertil Steril 1993;59:773.
17. Darai E, Benifla JL, Naouri M, et al. Transvaginal intratubal methotrexate treatment of ectopic pregnancy. Report of 100 cases. Hum Reprod 1996;11:420.
18. Merz E, Bahlmann F, Weber G, et al. Unruptured tubal pregnancy: local low-dose therapy with methotrexate under transvaginal ultrasonographic guidance. Gynecol Obstet Invest 1996;41:76.
19. Tasdemir M, Tasdemir S. Minimally invasive treatment of live ectopic pregnancy. Clin Exp Obstet Gynecol 1997;24:92.
20. Pouly JL, Chapron C, Manhes H, et al. Multifactorial analysis of fertility after conservative laparoscopic treatment of ectopic pregnancy in a series of 223 patients. Fertil Steril 1991;56:453.
21. Gervaise A, Masson L, de Tayrac R, et al. Reproductive outcome after methotrexate treatment of tubal pregnancies. Fertil Steril 2004;82:304.