Methadone and methadone metabolites in postmortem specimens

Forensic Science, Medicine, and Pathology

Volumn 4, Issue 3, 2008, Pages 170-174

  Danielson, Terry J ^a   Mozayani, Ashraf ^a   Sanchez, Luis A ^a  

^a Harris County Medical Examiner Office   (United States)

Author keywords

Blood; EDDP; EMDP; Forensic; HPLC MS MS; Liver; Methadone; Methadone metabolites; Postmortem; Toxicology

Indexed keywords

2 ETHYL 5 METHYL 3,3 DIPHENYLPYRROLINE; 2 ETHYLIDENE 1,5 DIMETHYL 3,3 DIPHENYLPYRROLIDINE; 2-ETHYL-5-METHYL-3,3-DIPHENYLPYRROLINE; 2-ETHYLIDENE-1,5-DIMETHYL-3,3-DIPHENYLPYRROLIDINE; METHADONE; NARCOTIC AGENT; PYRROLIDINE DERIVATIVE;

ARTICLE; CHEMISTRY; ENZYME LINKED IMMUNOSORBENT ASSAY; FORENSIC TOXICOLOGY; HUMAN; LIQUID CHROMATOGRAPHY; LIVER; TANDEM MASS SPECTROMETRY;

CHROMATOGRAPHY, LIQUID; ENZYME-LINKED IMMUNOSORBENT ASSAY; FORENSIC TOXICOLOGY; HUMANS; LIVER; METHADONE; NARCOTICS; PYRROLIDINES; TANDEM MASS SPECTROMETRY;

EID: 56749097793     PISSN: 1547769X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12024-008-9039-7     Document Type: Article

References (18)

1. SB Karch BG Stephens 2000 Toxicology and pathology of deaths related to methadone: retrospective review West J Med 172 11 4
2. CM Milroy ARW Forrest 2000 Methadone deaths: a toxicological analysis J Clin Pathol 53 277 81
3. A Gagajewski FS Apple 2003 Methadone-related deaths in Hennepin County, Minnesota: 1992-2002 J Forensic Sci 48 668 71
4. BC Wolf WA Lavezzi LM Sullivan LM Flannagan 2004 Methadone-related deaths in Palm Beach County J Forensic Sci 49 375 8
5. AH Beckett JF Taylor AF Casy MA Hasson 1968 The biotransformation of methadone in man. Synthesis and identification of a metabolite J Pharm Pharmacol 20 754 62
6. A Pohland HE Boaz HR Sullivan 1971 Synthesis and identification of metabolites resulting from the biotransformation of dl-methadone in man and the rat J Med Chem 14 194 7
7. ME Alburges W Huang RL Foltz DE Moody 1996 Determination of methadone and its N-demethylation metabolites in biological specimens by GC-PICI-MS J Anal Toxicol 20 362 8
8. RE Choo CM Murphy HE Jones MA Huestis 2005 Determination of methadone, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine, 2-ethyl-5-methyl-3,3- diphenylpyroline and methadol in meconium by liquid chromatography atmospheric pressure chemical ionization tandem mass spectrometry J Chromatogr B 814 369 73
9. DM Shakleya LM Jansson MA Huestis 2007 Validation of a LC-APCI-MS-MS method for quantification of methadone, 2-ethylidene-1, 5-dimethyl-3, 3-diphenylpyrrolidine (EDDP) and 2-ethyl-5-methyl-3, 3-diphenylpyroline (EMDP) in infant plasma following protein precipitation J Chromatogr B 856 267 72
10. HR Sullivan SL Due 1973 Urinary metabolites of d, l-methadone in maintenance subjects J Med Chem 16 909 13
11. K Verebely J Volavka M Salvatore R Resnick 1975 Methadone in man: pharmacokinetic and excretion studies in acute and chronic treatment Clin Pharmacol Ther 18 180 90
12. GL Henderson BK Wilson DHM Lau 1977 Plasma l-α-acetylmethadol (LAAM) after acute and chronic administration Clin Pharmacol Ther 21 16 25
13. RF Kaiko CE Inturrisi 1975 Disposition of acetylmethadol in relation to pharmacological action Clin Pharmacol Ther 18 96 103
14. RA Totah KE Allen P Sheffels D Whittington ED Kharasch 2007 Enantiomeric metabolic interactions and stereoselective human methadone metabolism J Pharmacol Exp Ther 321 389 99
15. CB Eap F Broly A Mino R Hammig C Uelinger D Meili AF Chevalley G Bertschy G Zullino M Kosel M Preisig P Baumann 2001 Cytochrome P450 2D6 genotype and methadone steady-state concentrations J Clin Psychopharmacol 21 229 34
16. S Crettol JJ Déglon J Besson M Croquette-Krokkar I Gothuey R Hämmig M Monnat H Hüttemann P Baumann CB Eap 2005 Methadone enantiomer plasma levels, CYP2B6, CYP2C19, and CYP2C9 genotypes, and response to treatment Clin Pharmacol Ther 78 593 604
17. S Begre U von Bardeleben D Ladewig S Jaquet-Rochat L Cosendai-Savary KP Golay M Kosel P Baumann CB Eap 2002 Paroxetine increases steady-state concentrations of (R)-methadone in CYP2D6 extensive but not poor metabolizers J Clin Psychopharmacol 22 211 5
18. C Uelinger S Crettol P Chasson L Koeb M Brawand-Amey CB Eap 2007 Increased (R)-methadone plasma concentrations by quetiapine in cytochrome P450s and ABCB1 genotyped patients J Clin Psychopharmacol 27 273 8