Staphylococcus aureus mediastinitis and sternal osteomyelitis following median sternotomy in a rat model

Journal of Antimicrobial Chemotherapy

Volumn 62, Issue 6, 2008, Pages 1339-1343

  Barnea, Yoav ^a   Carmeli, Yehuda ^a   Kuzmenko, Boris ^a   Navon Venezia, Shiri ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Antibiotic treatment; Experimental model; Infection; S. aureus; Vancomycin

Indexed keywords

VANCOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL COUNT; BACTERIAL GROWTH; BACTERIAL KINETICS; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; HISTOPATHOLOGY; INFECTION PREVENTION; MALE; MEDIASTINITIS; NONHUMAN; OSTEOMYELITIS; QUANTITATIVE ANALYSIS; RAT; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; STERNOTOMY; STERNUM OSTEOMYELITIS;

ANIMALS; ANTI-BACTERIAL AGENTS; COLONY COUNT, MICROBIAL; DISEASE MODELS, ANIMAL; MALE; MEDIASTINITIS; OSTEOMYELITIS; RATS; REPRODUCIBILITY OF RESULTS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; STERNUM; SURGICAL WOUND INFECTION; VANCOMYCIN;

EID: 56649122108     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkn378     Document Type: Article

References (24)

1. National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 to June 2002, issued August 2002. Am J Infect Control 2002; 30: 458-75.
2. Milano CA, Kesler K, Archibald N et al. Mediastinitis after coronary artery bypass graft surgery. Risk factors and long-term survival. Circulation 1995; 92: 2245-51.
3. Kappstein I, Schulgen G, Fraedrich G et al. Added hospital stay due to wound infections following cardiac surgery. Thorac Cardiovasc Surg 1992; 40: 148-51.
4. Asensio A, Torres J. Quantifying excess length of postoperative stay attributable to infections: A comparison of methods. J Clin Epidemiol 1999; 52: 1249-56.
5. Hollenbeak CS, Murphy D, Dunagan WC et al. Nonrandom selection and the attributable cost of surgical-site infections. Infect Control Hosp Epidemiol 2002; 23: 177-82.
6. Jenney AW, Harrington GA, Russo PL et al. Cost of surgical site infections following coronary artery bypass surgery. ANZ J Surg 2001; 71: 662-4.
7. Sharma M, Berriel-Cass D, Baran J Jr. Sternal surgical-site infection following coronary artery bypass graft: Prevalence, microbiology, and complications during a 42-month period. Infect Control Hosp Epidemiol 2004; 25: 468-71.
8. Fowler VG, Kaye KS, Simel DL et al. Staphylococcus aureus bacteremia after median sternotomy: Clinical utility of blood culture results in the identification of postoperative mediastinitis. Circulation 2003; 108: 73-8.
9. Tammelin A, Hambraeus A, Stahle E. Mediastinitis after cardiac surgery: improvement of bacteriological diagnosis by use of multiple tissue samples and strain typing. J Clin Microbiol 2002; 40: 2936-41.
10. Munoz P, Menasalvas A, Bernaldo de Quirós JC et al. Postsurgical mediastinitis: A case-control study. Clin Infect Dis 1997; 25: 1060-4.
11. Jakob HG, Borneff-Lipp M, Bach A et al. The endogenous pathway is a major route for deep sternal wound infection. Eur J Cardiothorac Surg 2000; 17: 154-60.
12. Dodds Ashley ES, Carroll DN, Engemann JJ et al. Risk factors for postoperative mediastinitis due to methicillin-resistant Staphylococcus aureus. Clin Infect Dis 2004; 38: 1555-60.
13. Braxton JH, Marrin CA, McGrath PD et al. Mediastinitis and long-term survival after coronary artery bypass graft surgery. Ann Thorac Surg 2000; 70: 2004-7.
14. Nishida H, Grooters RK, Merkley DF et al. Postoperative mediastinitis: A comparison of two electrocautery techniques on presternal soft tissues. J Thorac Cardiovasc Surg 1990; 99: 969-76.
15. Losanoff JE, Foerst JR, Huff H et al. Biomechanical porcine model of median sternotomy closure. J Surg Res 2002; 107: 108-12.
16. Andreopoulos D, Kasi LP, Edmund Kim E et al. Detection of acute postoperative mediastinitis in mice using (99m)Tc-liposomes. Invest Radiol 2002; 37: 435-9.
17. Lust RM, Sun SY, Chitwood WR Jr. Internal mammary artery use. Sternal revascularization and experimental infection patterns. Circulation 1991; 84 Suppl: III285-9.
18. Zehr KJ, Lee PC, Poston RS et al. Protection of the internal mammary artery pedicle with polytetrafluoroethylene membrane. J Card Surg 1993; 8: 650-5.
19. Iwakura A, Tabata Y, Koyama T et al. Gelatin sheet incorporating basic fibroblast growth factor enhances sternal healing after harvesting bilateral internal thoracic arteries. J Thorac Cardiovasc Surg 2003; 126: 1113-20.
20. Iwakura A, Tabata Y, Miyao M et al. Novel method to enhance sternal healing after harvesting bilateral internal thoracic arteries with use of basic fibroblast growth factor. Circulation 2000; 102 Suppl 3: III307-11.
21. Iwakura A, Tabata Y, Tamura N et al. Gelatin sheet incorporating basic fibroblast growth factor enhances healing of devascularized sternum in diabetic rats. Circulation 2001; 104 Suppl 1: 1325-9.
22. Ozcan AV, Demir M, Onem G et al. Topical versus systemic vancomycin for deep sternal wound infection caused by methicillin-resistant Staphylococcus aureus in a rodent experimental model. Tex Heart Inst J 2006; 33: 107-10.
23. Ersoz G, Aytacoglu BN, Sucu N et al. Comparison and evaluation of experimental mediastinitis models: Precolonized foreign body implants and bacterial suspension inoculation seems promising. BMC Infect Dis 2006; 6: 76.
24. Ogus TN, Hulusi Us M, Cic,ek S et al. Sternal cyanoacrylate gluing in mediastinitis. Effects on infection, stability and bone healing. J Cardiovasc Surg (Torino) 2002; 43: 741-6.