Inhibition of hyphae formation and SIR2 expression in Candida albicans treated with fresh Allium sativum (garlic) extract

Journal of Applied Microbiology

Volumn 105, Issue 6, 2008, Pages 2169-2177

  Low, C F ^a   Chong, P P ^a,b   Yong, P V C ^a   Lim, C S Y ^a   Ahmad, Z ^a   Othman, F ^a  

^a UPM   (Malaysia)

^b UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

Allium sativum; Candida albicans; SIR2 gene

Indexed keywords

CANDIDA; GENE ENCODING; POLYMERASE CHAIN REACTION; TRANSCRIPTION;

ALBICANS; ALLIUM SATIVUM; ASPARTYL PROTEINASE; CANDIDA ALBICANS; GARLIC EXTRACT; GENE EXPRESSION LEVELS; GENES ENCODING; MORPHOGENETICS; MORPHOLOGY TRANSFORMATIONS; SIR2 GENE;

YEAST;

ASPARTIC PROTEINASE; GARLIC EXTRACT;

ENZYME ACTIVITY; FUNGUS; GENE EXPRESSION; INHIBITION; MONOCOTYLEDON; MORPHOLOGY; PLANT EXTRACT; POLYMERASE CHAIN REACTION; VIRULENCE;

ANTIBIOTIC SENSITIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; FUNGAL GENE; FUNGAL MORPHOLOGY; FUNGAL VIRULENCE; FUNGUS HYPHAE; GENE EXPRESSION REGULATION; MICROSCOPY; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SAP4 GENE; SIR2 GENE;

ALLIUM SATIVUM; CANDIDA ALBICANS;

EID: 56649119064     PISSN: 13645072     EISSN: 13652672     Source Type: Journal    
DOI: 10.1111/j.1365-2672.2008.03912.x     Document Type: Article

References (21)

1. Ankri, S. Mirelman, D. (1999) Antimicrobial properties of allicin from garlic. Microbe Infect 1, 125 129.
2. Borg-von Zepelin, M., Beggah, S., Boggian, K., Sanglard, D. Monod, M. (1998) The expression of the secreted aspartyl proteinases Sap4 to Sap6 from Candida albicans in murine macrophages. Mol Microbiol 28, 543 554.
3. Chen, Y.C., Wu, C.C., Chung, W.L. Lee, F.J. (2002) Differential secretion of SAP4-6 proteins in Candida albicans during hyphae formation. J Microbiol 148, 3743 3754.
4. DeBernardis, F., Cassone, A., Sturtevant, J. Calderone, R. (1995) Expression of Candida albicans SAP1 and SAP2 in experimental vaginitis. Infect Immun 63, 1887 1892.
5. Edwards, J.E., Jr. (2000) Candida species. In Principles and Practice of Infectious Diseases ed. Mandell, G.L., Bennett, J.E. Dolin, R. pp. 2656 2673 London : Churchill Livingstone.
6. Ghannoum, M.A. (1988) Studies on the anti-Candidal mode of action of Allium sativum (garlic). J Gen Microbiol 134, 2917 2924.
7. Ghannoum, M.A. (1990) Inhibition of Candida adhesion to buccal epithelial cells by an aqueous extract of Allium sativum (garlic). J Appl Bacteriol 68, 163 169.
8. Ghannoum, M.A. (2000) Potential role of phospholipases in virulence and fungal pathogenesis. Clin Microbiol Rev 13, 122 143.
9. Hube, B., Monod, M., Schofield, D.A., Brown, A.J. Gow, N.A. (1994) Expression of seven members of the gene family encoding secretory aspartyl proteinases in Candida albicans. Mol Microbiol 14, 87 99.
10. Klar, A.J.S., Srikantha, T. Soll, D.R. (2001) A histone deacetylation inhibitor and mutant promote colony-type switching of the human pathogen Candida albicans. Genetics 158, 919 924.
11. Lemar, K.M., Turner, M.P. Lloyd, D. (2002) Garlic (Allium sativum) as an anti-Candida agent: a comparison of the efficacy of fresh garlic and freeze-dried extracts. J Appl Microbiol 93, 398 405.
12. Lemar, K.M., Passa, P., Aon, M.A., Cortassa, S., Müller, C.T., Plummer, S., O'Rourke, B. Lloyd, D. (2005) Allyl alcohol and garlic (Allium sativum) extract produce oxidative stress in Candida albicans. Microbiology 151, 3257 3265.
13. Lemar, K.M., Aon, M.A., Cortassa, S., O'Rourke, B., Müller, C.T. Lloyd, D. (2007) Diallyl disulphide depletes glutathione in Candida albicans: oxidative stress-mediated cell death studied by two-photon microscopy. Yeast 24, 695 706.
14. Messer, S.A., Jones, R.N. Fritsche, T.R. (2006) International surveillance of Candida spp. and Aspergillus spp.: report from the SENTRY Antimicrobial Surveillance Program. J Clin Microbiol 44, 1782 1787.
15. Pérez-Martín, J., Uría, J.A. Johnson, A.D. (1999) Phenotypic switching in Candida albicans is controlled by a SIR2 gene. EMBO J 18, 2580 2592.
16. Pfaller, M.A., Diekema, D.J., Jones, R.N., Sader, H.S., Fluit, A.C., Hollis, R.J., Messer, S.A. SENTRY Participant Group (2001) International surveillance of bloodstream infections due to Candida species: frequency of occurrence and in vitro susceptibilities to fluconazole, ravuconazole, and voriconazole of isolates collected from 1997 through 1999 in the SENTRY antimicrobial surveillance program. J Clin Microbiol 39, 3254 3259.
17. Rüchel, R., Zimmermann, F., Böning-Stutzer, B. Helmchen, U. (1991) Candidiasis visualised by proteinase-directed immunofluorescence. Virchows Arch A Pathol Anat Histopathol 419, 199 202.
18. San-Blas, G., Mariño, L., San-Blas, F. Apitz-Castro, R. (1993) Effect of ajoene on dimorphism of Paracoccidioides brasiliensis. J Med Vet Mycol 31, 133 141.
19. San-Blas, G., Urbina, J.A., Marchán, E., Contreras, L.M., Sorais, F. San-Blas, F. (1997) Inhibition of Paracoccidioides brasiliensis by ajoene is associated with blockade of phosphatidylcholine biosynthesis. Microbiology 143, 1583 1586.
20. Scherer, S. Magee, P.T. (1990) Genetics of Candida albicans. Microbiol Rev 54, 226 241.
21. Sudbery, P., Gow, N. Berman, J. (2004) The distinct morphogenic states of Candida albicans. Trends Microbiol 12, 317 324.