Saliva production and surface tension: Influences on patency of the passive upper airway

Journal of Physiology

Volumn 586, Issue 22, 2008, Pages 5537-5547

  Lam, J C M ^a   Kairaitis, Kristina ^b,c   Verma, M ^b   Wheatley, J R ^b,c   Amis, T C ^b,c  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b WESTMEAD HOSPITAL   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ATROPINE; METHACHOLINE; PENTOBARBITAL;

AIRWAY DYNAMICS; AIRWAY PRESSURE; ANIMAL EXPERIMENT; ARTICLE; ARTIFICIAL VENTILATION; AUTONOMIC NERVOUS SYSTEM FUNCTION; BREATHING MECHANICS; BREATHING MUSCLE; CONTROLLED STUDY; DATA ANALYSIS; DOSE RESPONSE; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SALIVATION; STERNOHYOID MUSCLE; SURFACE TENSION; UPPER RESPIRATORY TRACT; ADULT; HEART RATE; MEAN ARTERIAL PRESSURE; MUSCLE CONTRACTION; NEW ZEALAND WHITE (RABBIT); RESPIRATORY TRACT PARAMETERS; TRACHEOSTOMY; UPPER AIRWAY CLOSING PRESSURE; UPPER AIRWAY LINING LIQUID; UPPER AIRWAY LIQUID VOLUME INDEX; UPPER AIRWAY REOPENING PRESSURE; UPPER AIRWAY TRACT PATENCY;

ANIMALS; ATROPINE; HUMANS; MALE; METHACHOLINE CHLORIDE; MODELS, ANIMAL; PHARYNX; RABBITS; RESPIRATORY MECHANICS; RESPIRATORY PHYSIOLOGICAL PHENOMENA; RESPIRATORY SYSTEM; SALIVA; SURFACE TENSION; TRACHEA;

EID: 56649108205     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2008.159822     Document Type: Article

References (43)

1. Bianciotti LG, Elverdin JC, Vatta MS & Fernandez BE (1996). Atrial natriuretic factor modifies the composition of induced-salivary secretion in the rat. Regul Pept 65, 139-143.
2. Boucher RC, Stutts MJ, Bromberg PA & Gatzy JT (1981). Regional differences in airway surface liquid composition. J Appl Physiol 50, 613-620.
3. Carlson J, Hedner J, Elam M, Enjell H, Sellgren J & Wallin BG (1993). Augemented resting sympathetic activity in awake patients with obstructive sleep apnea. Chest 103, 1763-1768.
4. Chiu K-L, Ryan CM, Shiota S, Ruttanaumpawan P, Arzt M, Haight JS, Chan CT, Floras JS & Bradley TD (2006). Fluid shift by lower body positive pressure increases pharyngeal resistance in healthy subjects. Am J Resp Crit Care Med 174, 1378-1383.
5. Crawford AB, Van Der Touw T, O'Neill N & Amis TC (1996). Synthetic exogenous surfactant enhances patency of the passive airway in dogs. Am J Resp Crit Care Med 153, A692.
6. Dawes C (1972). Circadian rhythms in human salivary flow rates and composition. J Physiol 220, 529-545.
7. Ekstrom J, Garrett JR, Mansson B & Tobin G (1988). The effects of atropine and chronic sympathectomy on maximal parasympathetic stimulation of parotid saliva in rats. J Physiol 403, 105-116.
8. Fazekas A, Gazelius B, Edwall B, Theodorsson-Norheim E, Blomquist L & Lundberg J (1987). VIP and noncholinergic vasodilatation in rabbit submandibular gland. Peptides 8, 13-20.
9. Flecknell P (1996). Laboratory Animal Anaesthesia. Academic Press, London.
10. Gilman A, Goodman L, Rall T & Murad F (ed.) (1985). Goodman and Gilman's the Pharmacolgical Basis of Therapeutics. Macmillan Publishing Co., New York.
11. Glantz P (1970). The surface tension of saliva. Odontol Revy 21, 119-127.
12. Gleeson K, Zwillich CW, Braier K & White DP (1986). Breathing route during sleep. Am Rev Resp Dis 134, 115-120.
13. Hedner J, Ejnell H, Sellgren J, Hedner T & Wallin G (1988). Is high and fluctuating muscle sympathetic nervous activity in sleep apnea of pathogenic importance for the development of hypertension. J Hypertens Suppl 6, S529-S531.
14. Hilton MF, Chappell MJ, Bartlett WA, Malhotra A, Beattie JM & Cayton RM (2001). The sleep apnoea/hypopnoea syndrome depresses waking vagal tone independent of sympathetic activation. Eur Resp J 17, 1258-1266.
15. Jokic R, Klimaszewski A, Mink J & Fitzpatrick MF (1998). Surface tension forces in sleep apnea: Ahe role of a soft tissue lubricant: a randomized double-blind, placebo-controlled trial. Am J Resp Crit Care Med 157, 1522-1525.
16. Kairaitis K, Byth K, Parikh R, Stavrinou R, Wheatley J & Amis TC (2007). Tracheal traction effects on upper airway patency in rabbits: the role of tissue pressure. Sleep 30, 179-186.
17. Kales A, Cadieux R, Bixler E, Soldatos C, Vela-Bueno A, Misoul C & Locke T (1985). Severe obstructive sleep apnea - I: Onset, clinical course, and characteristics. J Chron Dis 38, 419-425.
18. Kirkness JP, Amis TC, Wheatley JR & Christenson HK (2000). Determining the surface tension of microliter amounts of liquid. J Colloid Interface Sci 232, 404-409.
19. Kirkness JP, Christenson HK, Garlick SR, Parikh R, Kairaitis K, Wheatley JR & Amis TC (2003a). Decreased surface tension of upper airway mucosal lining liquid increases upper airway patency in anaesthetised rabbits. J Physiol 547, 603-611.
20. Kirkness JP, Christenson HK, Wheatley JR & Amis TC (2005a). Application of the 'pull-off' force method for measurement of surface tension of upper airway mucosal lining liquid. Physiol Meas 26, 677-688.
21. Kirkness JP, Eastwood PR, Szollosi I, Platt PR, Wheatley JR, Amis TC & Hillman DR (2003b). Effect of surface tension of mucosal lining liquid on upper airway mechanics in anesthetized humans. J Appl Physiol 95, 357-363.
22. Kirkness JP, Madronio M, Stavrinou R, Wheatley JR & Amis TC (2003c). Relationship betwen surface tension of upper airway lining liquid and upper airway collapsibility during sleep in obstructive sleep apnoea hypopnea syndrome. J Appl Physiol 95, 1761-1766.
23. Kirkness JP, Madronio M, Stavrinou R, Wheatley JR & Amis TC (2005b). Surface tension of upper airway mucosal lining liquid in obstructive sleep apnea/hypopnea syndrome. Sleep 28, 457-463.
24. Lichter I & Muir R (1975). The pattern of swallowing during sleep. Electroencephalogr Clin Neurophysiol 38, 427-432.
25. Lonnerholm G & Widerlov E (1975). Effect of intravenous atropine and methylatropine on heart rate and secretion of saliva in man. Eur J Clin Pharmacol 8, 233-240.
26. Lundberg JM, Anggard A & Fahrenkrug J (1982). Complementary role of vasoactive intestinal polypeptide (VIP) and acetylcholine for cat submandibular gland blood flow and secretion. Acta Physiol Scand 114, 329-337.
27. Mandel I (1987). The functions of saliva. J Dent Res 66, 623-627.
28. Marrone O, Riccobono L, Salvaggio A, Mirabella A, Bonanno A & Bonsignore M (1993). Catecholamines and blood pressure in obstructive sleep apnea. Chest 103, 722-727.
29. Morrell MJ, Arabi Y, Zahn BR, Meyer KC, Skatrud JB & Badr MS (2002). Effect of surfactant on pharyngeal mechanics in sleeping humans: implications for sleep apnoea. Eur Resp J 20, 451-457.
30. Narkiewicz K, Montano N, Cogliati C, van de Borne PJ, Dyken ME & Somers VK (1998). Altered cardiovascular variability in obstructive sleep apnea. Circulation 98, 1071-1077.
31. Olson LG & Strohl KP (1988). Airway secretions influence upper airway patency in the rabbit. Am Rev Resp Dis 137, 1379-1381.
32. Olson LG, Ulmer LG & Saunders NA (1989). Influence of muscle activity on the elastance of the upper airway of rabbits. J Appl Physiol 66, 755-758.
33. Ostuni M, Raimondi A & Tumilasci O (1999). Modulation by somatostatin of rat parotid salivary secretion stimulated by cholinergic, adrenergic and peptidergic agents. Arch Oral Biol 44, 549-556.
34. Pinheiro JC & Bates DM (2000). Mixed Effects Models in S and S-PLUS. Springer-Verlag, New York.
35. Rothstein RJ, Narce SL, deBerry-Borowiecki B & Blanks RH (1983). Respiratory-related activity of upper airway muscles in anesthetized rabbit. J Appl Physiol 55, 1830-1836.
36. Yu JH & Schneyer CA (1984). Effects of varying frequency of parasympathetic nerve stimulation on flow rate and ion concentrations of rat submandibular saliva. Arch Oral Biol 29, 551-553.
37. Shepard JW, Pevernagie DA, Stanson AW, Daniels BK & Sheedy PF (1996). Effects of changes in central venous pressure on upper airway size in patients with obstructive sleep apnoea. Am J Resp Crit Care Med 153, 250-254.
38. Shiota S, Ryan CM, Chiu K-L, Ruttanaumpawan P, Haight J, Arzt M, Floras JS, Chan C & Bradley TD (2007). Alterations in upper airway cross-sectional area in response to lower body positive pressure in healthy subjects. Thorax 62, 868-872.
39. Thie N, Kato T, Bader G, Montplaisir J & Lavigne G (2002). The significance of saliva during sleep and the relevance of oromotor movements. Sleep Med Rev 6, 213-227.
40. Valdez I & Fox P (1991). Interactions of the salivary and gastrointestinal systems. I. The role of saliva in digestion. Dig Dis 9, 125-132.
41. Van de Graaff WB, Gottfried SB, Mitra J, van Lunteren E, Cherniack NS & Strohl KP (1984). Respiratory function of hyoid muscles and hyoid arch. J Appl Physiol 57, 197-204.
42. Verma M, Seto-Poon M, Wheatley JR, Amis TC & Kirkness JP (2006). Influence of breathing route on upper airway lining liquid surface tension in humans. J Physiol 574, 859-866.
43. Woodall DL, Hokanson JA & Mathew OP (1989). Time of application of negative pressure pulses and upper airway muscle activity. J Appl Physiol 67, 366-370.