Loss of WWOX expression in human extrahepatic cholangiocarcinoma

Journal of Cancer Research and Clinical Oncology

Volumn 135, Issue 1, 2009, Pages 39-44

  Wang, Mei ^a   Gu, Jun ^a   Wang, Yajie ^a   Gong, Biao ^b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

Author keywords

Extrahepatic cholangiocarcinoma; Immunohistochemistry; Loss of heterozygosity; Real time reverse transcription polymerase chain reaction

Indexed keywords

MESSENGER RNA;

ADULT; ARTICLE; BILE DUCT CARCINOMA; CANCER STAGING; CARCINOGENESIS; CLINICAL ARTICLE; DISEASE COURSE; EXTRAHEPATIC CHOLANGIOCARCINOMA; FEMALE; GENE EXPRESSION; GENE FUNCTION; HETEROZYGOSITY LOSS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CARCINOMA; LIVER FUNCTION; MALE; NUCLEOTIDE SEQUENCE; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE; WWOX GENE;

BILE DUCT NEOPLASMS; BILE DUCTS, EXTRAHEPATIC; BILE DUCTS, INTRAHEPATIC; CHOLANGIOCARCINOMA; DNA, NEOPLASM; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; LOSS OF HETEROZYGOSITY; MALE; MIDDLE AGED; OXIDOREDUCTASES; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; RNA, MESSENGER; RNA, NEOPLASM; TUMOR SUPPRESSOR PROTEINS;

EID: 56649108097     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-008-0449-4     Document Type: Article

References (16)

1. RI Aqeilan T Kuroki Y Pekarsky 2004 Croce. Loss of WWOX expressin in gastric carcinoma Clin Cancer Res 10 3053 3058 10.1158/1078-0432.CCR-03-0594
2. R Baffa ML Veronese R Santoro 1998 Loss of FHIT expression in gastric carcinoma Cancer Res 58 4708 4714
3. AK Bednarek KJ Laflin RL Daniel 2000 WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer Cancer Res 60 2140 2145
4. AK Bednarek CL Keck RL Daniel 2001 WWOX, the FRA16D gene, behaves as a suppressor of tumor growth Cancer Res 61 8068 8073
5. D Capuzzi E Santoro WW Hauck 2000 Fhit expression in gastric adenocarcinoma: correlation with disease stage and survival Cancer (Phila) 88 24 34
6. K Driouch H Prydz R Monese 2002 Alternative transcripts of the candidate tumor suppressor gene, WWOX, are expressed at high levels in human breast tumors Oncogene 21 1832 1840
7. K Huebner CM Croce 2001 FRA3B and other common fragile sites: the weakest links Nat Rev Cancer 1 214 221 10.1038/35106058
8. T Kuroki F Trapasso T Shiraishi 2002 Genetic alterations of the tumor suppressor gene WWOX in esophageal squamous cell carcinoma Cancer Res 62 2258 2260
9. T Kuroki S Yendamuri F Trapasso 2004 The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis Clin Cancer Res 10 2459 2465 10.1158/1078-0432.CCR-03-0096
10. H Malhi GJ Gores 2006 Review article: the modern diagnosis and therapy of cholangiocarcinoma Aliment Pharmacol Ther 23 9 1287 1296
11. AJ Paige KJ Taylor C Taylor 2001 WWOX: a candidate tumor suppressor gene involved in multiple tumor types Proc Natl Acad Sci USA 98 11417 11422 10.1073/pnas.191175898
12. SW Park J Luded-Meyers DB Zimonjic 2004 Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma Br J Cancer 91 753 759
13. SR Ridruejo BB Jimenez 2006 Infected cholangiocarcinoma Med Interna 23 7 335 337
14. K Ried M Finnis L Hobson 2000 Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints incancer cells Hum Mol Genet 9 1651 1663
15. MC Yakicier P Legoix C Vaury 2001 Identification of homozygous deletions at chromosome 16q23 in aflatoxin B1 exposed hepatocellular carcinoma Oncogene 20 37 5232 5238 10.1038/sj.onc.1204674
16. S Yendamuri T Kuroki F Trapasso 2003 WW domain containing oxidoreductase gene expression is altered in non-small cell lung cancer Cancer Res 63 878 881