메뉴 건너뛰기




Volumn 36, Issue 20, 2008, Pages 6372-6385

Stra13/DEC1 and DEC2 inhibit sterol regulatory element binding protein-1c in a hypoxia-inducible factor-dependent mechanism

Author keywords

[No Author keywords available]

Indexed keywords

DIFFERENTIATED EMBRYO CHONDROCYTE 1; DIFFERENTIATED EMBRYO CHONDROCYTE 2; HYPOXIA INDUCIBLE FACTOR 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; STIMULATED WITH RETINOIC ACID; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 56649103933     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkn620     Document Type: Article
Times cited : (50)

References (58)
  • 1
    • 0022590628 scopus 로고
    • Defense strategies against hypoxia and hypothermia
    • Hochachka,P.W. (1986) Defense strategies against hypoxia and hypothermia. Science, 231, 234-241.
    • (1986) Science , vol.231 , pp. 234-241
    • Hochachka, P.W.1
  • 2
    • 33644614520 scopus 로고    scopus 로고
    • HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
    • Kim,J.W., Tchernyshyov,I., Semenza,G.L. and Dang,C.V. (2006) HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia. Cell Metab., 3, 177-185.
    • (2006) Cell Metab , vol.3 , pp. 177-185
    • Kim, J.W.1    Tchernyshyov, I.2    Semenza, G.L.3    Dang, C.V.4
  • 3
    • 34247614521 scopus 로고    scopus 로고
    • HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
    • Zhang,H., Gao,P., Fukuda,R., Kumar,G., Krishnamachary,B., Zeller,K.I., Dang,C.V. and Semenza,G.L. (2007) HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell, 11, 407-420.
    • (2007) Cancer Cell , vol.11 , pp. 407-420
    • Zhang, H.1    Gao, P.2    Fukuda, R.3    Kumar, G.4    Krishnamachary, B.5    Zeller, K.I.6    Dang, C.V.7    Semenza, G.L.8
  • 4
    • 33644622570 scopus 로고    scopus 로고
    • HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
    • Papandreou,I., Cairns,R.A., Fontana,L., Lim,A.L. and Denko,N.C. (2006) HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab., 3, 187-197.
    • (2006) Cell Metab , vol.3 , pp. 187-197
    • Papandreou, I.1    Cairns, R.A.2    Fontana, L.3    Lim, A.L.4    Denko, N.C.5
  • 5
    • 0035917808 scopus 로고    scopus 로고
    • 2-regulated prolyl hydroxylation. Science 292, 468-472.
    • 2-regulated prolyl hydroxylation. Science 292, 468-472.
  • 9
    • 0029796904 scopus 로고    scopus 로고
    • Unifying theory of hypoxia tolerance: Molecular/metabolic defense and rescue mechanisms for surviving oxygen lack
    • Hochachka,P.W., Buck,L.T., Doll,C.J. and Land,S.C. (1996) Unifying theory of hypoxia tolerance: Molecular/metabolic defense and rescue mechanisms for surviving oxygen lack. Proc. Natl Acad. Sci. USA, 93, 9493-9498.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 9493-9498
    • Hochachka, P.W.1    Buck, L.T.2    Doll, C.J.3    Land, S.C.4
  • 10
    • 0035038782 scopus 로고    scopus 로고
    • Mechanisms of nutritional and hormonal regulation of lipogenesis
    • Kersten,S. (2001) Mechanisms of nutritional and hormonal regulation of lipogenesis. EMBO Rep., 2, 282-286.
    • (2001) EMBO Rep , vol.2 , pp. 282-286
    • Kersten, S.1
  • 12
    • 0028875426 scopus 로고
    • Sterol regulation of fatty acid synthase promoter. Coordinate feedback regulation of two major lipid pathways
    • Bennett,M.K., Lopez,J.M., Sanchez,H.B. and Osborne,T.F. (1995) Sterol regulation of fatty acid synthase promoter. Coordinate feedback regulation of two major lipid pathways. J. Biol. Chem., 270, 25578-25583.
    • (1995) J. Biol. Chem , vol.270 , pp. 25578-25583
    • Bennett, M.K.1    Lopez, J.M.2    Sanchez, H.B.3    Osborne, T.F.4
  • 13
    • 0028897395 scopus 로고
    • In vivo effects of hyperinsulinemia on lipogenic enzymes and glucose transporter expression in rat liver and adipose tissues
    • Assimacopoulos-Jeannet,F., Brichard,S., Rencurel,F., Cusin,I. and Jeanrenaud,B. (1995) In vivo effects of hyperinsulinemia on lipogenic enzymes and glucose transporter expression in rat liver and adipose tissues. Metabolism, 44, 228-233.
    • (1995) Metabolism , vol.44 , pp. 228-233
    • Assimacopoulos-Jeannet, F.1    Brichard, S.2    Rencurel, F.3    Cusin, I.4    Jeanrenaud, B.5
  • 14
    • 0028963743 scopus 로고
    • Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain
    • Kim,J.B., Spotts,G.D., Halvorsen,Y.D., Shih,H.M., Ellenberger,T., Towle,H.C. and Spiegelman,B.M. (1995) Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain. Mol. Cell. Biol., 15, 2582-2588.
    • (1995) Mol. Cell. Biol , vol.15 , pp. 2582-2588
    • Kim, J.B.1    Spotts, G.D.2    Halvorsen, Y.D.3    Shih, H.M.4    Ellenberger, T.5    Towle, H.C.6    Spiegelman, B.M.7
  • 15
    • 0030961960 scopus 로고    scopus 로고
    • Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells
    • Shimomura,I., Shimano,H., Horton,J.D., Goldstein,J.L. and Brown,M.S. (1997) Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. J. Clin. Invest., 99, 838-845.
    • (1997) J. Clin. Invest , vol.99 , pp. 838-845
    • Shimomura, I.1    Shimano, H.2    Horton, J.D.3    Goldstein, J.L.4    Brown, M.S.5
  • 18
    • 19344361859 scopus 로고    scopus 로고
    • Regulation of SREBP-1 expression and transcriptional action on HKII and FAS genes during fasting and refeeding in rat tissues
    • Gosmain,Y., Dif,N., Berbe,V., Loizon,E., Rieusset,J., Vidal,H. and Lefai,E. (2005) Regulation of SREBP-1 expression and transcriptional action on HKII and FAS genes during fasting and refeeding in rat tissues. J. Lipid. Res., 46, 697-705.
    • (2005) J. Lipid. Res , vol.46 , pp. 697-705
    • Gosmain, Y.1    Dif, N.2    Berbe, V.3    Loizon, E.4    Rieusset, J.5    Vidal, H.6    Lefai, E.7
  • 19
    • 3843061127 scopus 로고    scopus 로고
    • Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver
    • Chen,G., Liang,G., Ou,J., Goldstein,J.L. and Brown,M.S. (2004) Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver. Proc. Natl Acad. Sci. USA, 101, 11245-11250.
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 11245-11250
    • Chen, G.1    Liang, G.2    Ou, J.3    Goldstein, J.L.4    Brown, M.S.5
  • 20
    • 0036198010 scopus 로고    scopus 로고
    • Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: A mechanism for regulation of adipogenesis by hypoxia
    • Yun,Z., Maecker,H.L., Johnson,R.S. and Giaccia,A.J. (2002) Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: A mechanism for regulation of adipogenesis by hypoxia. Dev. Cell, 2, 331-341.
    • (2002) Dev. Cell , vol.2 , pp. 331-341
    • Yun, Z.1    Maecker, H.L.2    Johnson, R.S.3    Giaccia, A.J.4
  • 21
    • 0037033095 scopus 로고    scopus 로고
    • Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes
    • Miyazaki,K., Kawamoto,T., Tanimoto,K., Nishiyama,M., Honda,H. and Kato,Y. (2002) Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes. J. Biol. Chem., 277, 47014-47021.
    • (2002) J. Biol. Chem , vol.277 , pp. 47014-47021
    • Miyazaki, K.1    Kawamoto, T.2    Tanimoto, K.3    Nishiyama, M.4    Honda, H.5    Kato, Y.6
  • 22
    • 21344471947 scopus 로고    scopus 로고
    • Basic helix-loop-helix transcription factors, BHLHB2 and BHLHB3; their gene expressions are regulated by multiple extracellular stimuli
    • Yamada,K. and Miyamoto,K. (2005) Basic helix-loop-helix transcription factors, BHLHB2 and BHLHB3; their gene expressions are regulated by multiple extracellular stimuli. Front Biosci., 10, 3151-3171.
    • (2005) Front Biosci , vol.10 , pp. 3151-3171
    • Yamada, K.1    Miyamoto, K.2
  • 25
    • 33845922640 scopus 로고    scopus 로고
    • Clioquinol, a Cu(II)/Zn(II) chelator, inhibits both ubiquitination and asparagine hydroxylation of hypoxia-inducible factor-1alpha, leading to expression of vascular endothelial growth factor and erythropoietin in normoxic cells
    • Choi,S.M., Choi,K.O., Park,Y.K., Cho,H., Yang,E.G. and Park,H. (2006) Clioquinol, a Cu(II)/Zn(II) chelator, inhibits both ubiquitination and asparagine hydroxylation of hypoxia-inducible factor-1alpha, leading to expression of vascular endothelial growth factor and erythropoietin in normoxic cells. J. Biol. Chem., 281, 34056-34063.
    • (2006) J. Biol. Chem , vol.281 , pp. 34056-34063
    • Choi, S.M.1    Choi, K.O.2    Park, Y.K.3    Cho, H.4    Yang, E.G.5    Park, H.6
  • 26
    • 0141643339 scopus 로고    scopus 로고
    • Insulin and hypoxia share common target genes but not the hypoxia-inducible factor-1alpha
    • Yim,S., Choi,S.M., Choi,Y., Lee,N., Chung,J. and Park,H. (2003) Insulin and hypoxia share common target genes but not the hypoxia-inducible factor-1alpha. J. Biol. Chem., 278, 38260-38268.
    • (2003) J. Biol. Chem , vol.278 , pp. 38260-38268
    • Yim, S.1    Choi, S.M.2    Choi, Y.3    Lee, N.4    Chung, J.5    Park, H.6
  • 27
    • 40649089223 scopus 로고    scopus 로고
    • Analysis of epigenetic modifications of chromatin at specific gene loci by native chromatin immunoprecipitation of nucleosomes isolated using hydroxyapatite chromatography
    • Brand,M., Rampalli,S., Chaturvedi,C.P. and Dilworth,F.J. (2008) Analysis of epigenetic modifications of chromatin at specific gene loci by native chromatin immunoprecipitation of nucleosomes isolated using hydroxyapatite chromatography. Nat. Protoc., 3, 398-409.
    • (2008) Nat. Protoc , vol.3 , pp. 398-409
    • Brand, M.1    Rampalli, S.2    Chaturvedi, C.P.3    Dilworth, F.J.4
  • 28
    • 0020680990 scopus 로고
    • A peroxidase-coupled method for the colorimetric determination of serum triglycerides
    • McGowan,M.W., Artiss,J.D., Strandbergh,D.R. and Zak,B. (1983) A peroxidase-coupled method for the colorimetric determination of serum triglycerides. Clin. Chem., 29, 538-542.
    • (1983) Clin. Chem , vol.29 , pp. 538-542
    • McGowan, M.W.1    Artiss, J.D.2    Strandbergh, D.R.3    Zak, B.4
  • 29
    • 0031015287 scopus 로고    scopus 로고
    • Exogenous oxidized low-density lipoprotein injures and alters the barrier function of endothelium in rats in vivo
    • Rangaswamy,S., Penn,M.S., Saidel,G.M. and Chisolm,G.M. (1997) Exogenous oxidized low-density lipoprotein injures and alters the barrier function of endothelium in rats in vivo. Circ. Res., 80, 37-44.
    • (1997) Circ. Res , vol.80 , pp. 37-44
    • Rangaswamy, S.1    Penn, M.S.2    Saidel, G.M.3    Chisolm, G.M.4
  • 30
    • 11144356074 scopus 로고    scopus 로고
    • Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor gamma expression
    • Seo,J.B., Moon,H.M., Kim,W.S., Lee,Y.S., Jeong,H.W., Yoo,E.J., Ham,J., Kang,H., Park,M.G., Steffensen,K.R. et al. (2004) Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor gamma expression. Mol. Cell. Biol., 24, 3430-3444.
    • (2004) Mol. Cell. Biol , vol.24 , pp. 3430-3444
    • Seo, J.B.1    Moon, H.M.2    Kim, W.S.3    Lee, Y.S.4    Jeong, H.W.5    Yoo, E.J.6    Ham, J.7    Kang, H.8    Park, M.G.9    Steffensen, K.R.10
  • 32
    • 56649099909 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor nuclear translocator is involved in ATP homeostasis in both normoxic and hypoxic monolayer mouse hepatoma cells
    • Choi,S.M. and Park,H. (2006) Aryl hydrocarbon receptor nuclear translocator is involved in ATP homeostasis in both normoxic and hypoxic monolayer mouse hepatoma cells. J. Appl. Pharmacol., 14, 132-136.
    • (2006) J. Appl. Pharmacol , vol.14 , pp. 132-136
    • Choi, S.M.1    Park, H.2
  • 34
    • 0029655655 scopus 로고    scopus 로고
    • Dioxin-induced CYP1A1 transcription in vivo: The aromatic hydrocarbon receptor mediates transactivation, enhancer-promoter communication, and changes in chromatin structure
    • Ko,H.P., Okino,S.T., Ma,Q. and Whitlock,J.P. Jr. (1996) Dioxin-induced CYP1A1 transcription in vivo: The aromatic hydrocarbon receptor mediates transactivation, enhancer-promoter communication, and changes in chromatin structure. Mol. Cell. Biol., 16, 430-436.
    • (1996) Mol. Cell. Biol , vol.16 , pp. 430-436
    • Ko, H.P.1    Okino, S.T.2    Ma, Q.3    Whitlock Jr., J.P.4
  • 36
    • 12744271884 scopus 로고    scopus 로고
    • Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis-acting elements
    • Cagen,L.M., Deng,X., Wilcox,H.G., Park,E.A., Raghow,R. and Elam,M.B. (2005) Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis-acting elements. Biochem. J., 385 207-216.
    • (2005) Biochem. J , vol.385 , pp. 207-216
    • Cagen, L.M.1    Deng, X.2    Wilcox, H.G.3    Park, E.A.4    Raghow, R.5    Elam, M.B.6
  • 37
    • 0037930808 scopus 로고    scopus 로고
    • DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter
    • Li,Y., Xie,M., Song,X., Gragen,S., Sachdeva,K., Wan,Y. and Yan,B. (2003) DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter. J. Biol. Chem., 278, 16899-16907.
    • (2003) J. Biol. Chem , vol.278 , pp. 16899-16907
    • Li, Y.1    Xie, M.2    Song, X.3    Gragen, S.4    Sachdeva, K.5    Wan, Y.6    Yan, B.7
  • 39
    • 12644314084 scopus 로고    scopus 로고
    • Two tandem binding sites for sterol regulatory element binding proteins are required for sterol regulation of fatty-acid synthase promoter
    • Magana,M.M. and Osborne,T.F. (1996) Two tandem binding sites for sterol regulatory element binding proteins are required for sterol regulation of fatty-acid synthase promoter. J. Biol. Chem., 271, 32689-32694.
    • (1996) J. Biol. Chem , vol.271 , pp. 32689-32694
    • Magana, M.M.1    Osborne, T.F.2
  • 40
    • 0030868519 scopus 로고    scopus 로고
    • Sterol regulation of acetyl coenzyme A carboxylase promoter requires two interdependent binding sites for sterol regulatory element binding proteins
    • Magana,M.M., Lin,S.S., Dooley,K.A. and Osborne,T.F. (1997) Sterol regulation of acetyl coenzyme A carboxylase promoter requires two interdependent binding sites for sterol regulatory element binding proteins. J. Lipid Res., 38, 1630-1638.
    • (1997) J. Lipid Res , vol.38 , pp. 1630-1638
    • Magana, M.M.1    Lin, S.S.2    Dooley, K.A.3    Osborne, T.F.4
  • 42
    • 34447556690 scopus 로고    scopus 로고
    • Multiple mechanisms regulate circadian expression of the gene for cholesterol 7alpha-hydroxylase (Cyp7a), a key enzyme in hepatic bile acid biosynthesis
    • Noshiro,M., Usui,E., Kawamoto,T., Kubo,H., Fujimoto,K., Furukawa,M., Honma,S., Makishima,M., Honma,K. and Kato,Y. (2007) Multiple mechanisms regulate circadian expression of the gene for cholesterol 7alpha-hydroxylase (Cyp7a), a key enzyme in hepatic bile acid biosynthesis. J. Biol. Rhythms, 22, 299-311.
    • (2007) J. Biol. Rhythms , vol.22 , pp. 299-311
    • Noshiro, M.1    Usui, E.2    Kawamoto, T.3    Kubo, H.4    Fujimoto, K.5    Furukawa, M.6    Honma, S.7    Makishima, M.8    Honma, K.9    Kato, Y.10
  • 44
    • 4744373356 scopus 로고    scopus 로고
    • DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1
    • Li,Y., Song,X., Ma,Y., Liu,J., Yang,D. and Yan,B. (2004) DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1. Biochem. J., 382, 895-904.
    • (2004) Biochem. J , vol.382 , pp. 895-904
    • Li, Y.1    Song, X.2    Ma, Y.3    Liu, J.4    Yang, D.5    Yan, B.6
  • 48
    • 0035065450 scopus 로고    scopus 로고
    • Disturbances in the normal regulation of SREBP-sensitive genes in PPAR alpha-de.cient mice
    • Patel,D.D., Knight,B.L., Wiggins,D., Humphreys,S.M. and Gibbons,G.F. (2001) Disturbances in the normal regulation of SREBP-sensitive genes in PPAR alpha-de.cient mice. J. Lipid Res., 42, 328-337.
    • (2001) J. Lipid Res , vol.42 , pp. 328-337
    • Patel, D.D.1    Knight, B.L.2    Wiggins, D.3    Humphreys, S.M.4    Gibbons, G.F.5
  • 49
    • 0033572654 scopus 로고    scopus 로고
    • Functional antagonism between inhibitor of DNA binding (Id) and adipocyte determination and differentiation factor 1/sterol regulatory element-binding protein-1c (ADD1/SREBP-1c) trans-factors for the regulation of fatty acid synthase promoter in adipocytes
    • Moldes,M., Boizard,M., Liepvre,X.L., Feve,B., Dugail,I. and Pairault,J. (1999) Functional antagonism between inhibitor of DNA binding (Id) and adipocyte determination and differentiation factor 1/sterol regulatory element-binding protein-1c (ADD1/SREBP-1c) trans-factors for the regulation of fatty acid synthase promoter in adipocytes. Biochem. J. 344, 873-880.
    • (1999) Biochem. J , vol.344 , pp. 873-880
    • Moldes, M.1    Boizard, M.2    Liepvre, X.L.3    Feve, B.4    Dugail, I.5    Pairault, J.6
  • 50
    • 34247119238 scopus 로고    scopus 로고
    • Direct interaction between USF and SREBP-1c mediates synergistic activation of the fatty acid synthase promoter
    • Griffin,M.J., Wong,R.H., Pandya,N. and Sul,H.S. (2006) Direct interaction between USF and SREBP-1c mediates synergistic activation of the fatty acid synthase promoter. J. Biol. Chem., 282, 5453-5467.
    • (2006) J. Biol. Chem , vol.282 , pp. 5453-5467
    • Griffin, M.J.1    Wong, R.H.2    Pandya, N.3    Sul, H.S.4
  • 51
    • 0035797525 scopus 로고    scopus 로고
    • Cross-regulatory interaction between Stra13 and USF results in functional antagonism
    • Dhar,M. and Taneja,R. (2001) Cross-regulatory interaction between Stra13 and USF results in functional antagonism. Oncogene, 20, 4750-4756.
    • (2001) Oncogene , vol.20 , pp. 4750-4756
    • Dhar, M.1    Taneja, R.2
  • 52
    • 34748912615 scopus 로고    scopus 로고
    • Fatty acid synthase and the lipogenic phenotype in cnacer pathogenesis
    • Menendez,J.A. and Lupu,R. (2007) Fatty acid synthase and the lipogenic phenotype in cnacer pathogenesis. Nat. Rev. Cancer, 7, 763-777.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 763-777
    • Menendez, J.A.1    Lupu, R.2
  • 53
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
    • DeBerardinis,R.J., Lum,J.J., Hatzivassiliou,G. and Thompson,C.B. (2008) The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation. Cell Metab., 7, 11-20.
    • (2008) Cell Metab , vol.7 , pp. 11-20
    • DeBerardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 56
    • 34247631690 scopus 로고    scopus 로고
    • The transcription factor HIF-1α plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis
    • Lum,J.J., Bui,T., Gruber,M., Gordan,J.D., DeBerardinis,R.J., Covello,K.L., Simon,M.C. and Thompson,C.B. (2007) The transcription factor HIF-1α plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev., 21, 1037-1049.
    • (2007) Genes Dev , vol.21 , pp. 1037-1049
    • Lum, J.J.1    Bui, T.2    Gruber, M.3    Gordan, J.D.4    DeBerardinis, R.J.5    Covello, K.L.6    Simon, M.C.7    Thompson, C.B.8
  • 57
    • 0037177867 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1α nor sufficient for HIF-1-dependent target gene transcription
    • Arsham,A.M., Plas,D.R., Thompson,C.B. and Simon,M.C. (2002) Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1α nor sufficient for HIF-1-dependent target gene transcription. J. Biol. Chem., 277, 15162-15170.
    • (2002) J. Biol. Chem , vol.277 , pp. 15162-15170
    • Arsham, A.M.1    Plas, D.R.2    Thompson, C.B.3    Simon, M.C.4
  • 58
    • 39549117982 scopus 로고    scopus 로고
    • Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1
    • Furuta,E., Pai,S.K., Zhan,R., Bandyopadhyay,S., Watabe,M., Mo,Y.Y., Hirota,S., Hosobe,S., Tsukada,T., Miura,K. et al. (2008) Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1. Cancer Res., 68 1003-1011.
    • (2008) Cancer Res , vol.68 , pp. 1003-1011
    • Furuta, E.1    Pai, S.K.2    Zhan, R.3    Bandyopadhyay, S.4    Watabe, M.5    Mo, Y.Y.6    Hirota, S.7    Hosobe, S.8    Tsukada, T.9    Miura, K.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.