Introduction into Cav2.1 of the homologous mutation of Ca v1.2 causing the Timothy syndrome questions the role of V421 in the phenotypic definition of P-type Ca2+ channel

Pflugers Archiv European Journal of Physiology

Volumn 457, Issue 2, 2008, Pages 417-430

  Cens, Thierry ^a,b   Leyris, Jean Philippe ^a,b   Charnet, Pierre ^a,b  

^a Centre National de la Recherche Scientifique   (France)

^b UNIV MONTPELLIER   (France)

Author keywords

Calcium channels; G protein regulation; Inactivation rate regulation; P Q type; Xenopus oocytes

Indexed keywords

ARGININE; CALCIUM CHANNEL; CALCIUM CHANNEL P TYPE; GLUTAMIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; VALINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA CHAIN; CHANNEL GATING; CONTROLLED STUDY; GENERAL ASPECTS OF DISEASE; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; TIMOTHY SYNDROME; WILD TYPE;

ALANINE; ANIMALS; ARGININE; ARRHYTHMIAS, CARDIAC; CALCIUM; CALCIUM CHANNELS, L-TYPE; CALCIUM CHANNELS, N-TYPE; CALCIUM CHANNELS, R-TYPE; CATION TRANSPORT PROTEINS; COGNITION DISORDERS; GENOTYPE; GLUTAMIC ACID; GLYCINE; GTP-BINDING PROTEINS; ION CHANNEL GATING; KINETICS; MEMBRANE POTENTIALS; MUTATION; PHENOTYPE; RATS; SYNDROME; VALINE; XENOPUS;

EID: 56649100668     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-008-0534-1     Document Type: Article

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