Allergen-induced airway hyperresponsiveness is absent in ecto-5′-nucleotidase (CD73)-deficient mice

Pflugers Archiv European Journal of Physiology

Volumn 457, Issue 2, 2008, Pages 431-440

  Schreiber, Rainer ^a   Castrop, Hayo ^a   Kunzelmann, Karl ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Adenosine; Adenosine diphosphate (ADP); Airways; Asthma; CD73; Chloride secretion; Chloride transport; Ecto 5 nucleotidase; Electrolyte transport; Mucociliary clearance; P2 purinergic receptor; Respiratory epithelia

Indexed keywords

5' NUCLEOTIDASE; ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; ALLERGEN; METHACHOLINE; OVALBUMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BAGG ALBINO MOUSE; CONTROLLED STUDY; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR MOUSE; ELECTRON TRANSPORT; ENZYME ACTIVATION; FEMALE; MALE; MOUSE; MUCOCILIARY CLEARANCE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; TRACHEA; UPREGULATION;

5'-NUCLEOTIDASE; ADENINE NUCLEOTIDES; ADENOSINE; ALLERGENS; ANIMALS; BRONCHIAL HYPERREACTIVITY; BRONCHIAL PROVOCATION TESTS; BRONCHOCONSTRICTION; BRONCHOCONSTRICTOR AGENTS; CHLORIDES; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; METHACHOLINE CHLORIDE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MUCOCILIARY CLEARANCE; OVALBUMIN; TRACHEA;

EID: 56649088240     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-008-0543-0     Document Type: Article

References (22)

1. AG Driver CA Kukoly S Ali SJ Mustafa 1993 Adenosine in bronchoalveolar lavage fluid in asthma Am Rev Respir Dis 148 91 97
2. JS Mann ST Holgate AG Renwick MJ Cushley 1986 Airway effects of purine nucleosides and nucleotides and release with bronchial provocation in asthma J Appl Physiol 61 1667 1676
3. A Mohsenin MR Blackburn 2006 Adenosine signaling in asthma and chronic obstructive pulmonary disease Curr Opin Pulm Med 12 54 59
4. MR Blackburn JB Volmer JL Thrasher H Zhong JR Crosby JJ Lee RE Kellems 2000 Metabolic consequences of adenosine deaminase deficiency in mice are associated with defects in alveogenesis, pulmonary inflammation, and airway obstruction J Exp Med 192 159 170
5. MJ Bours EL Swennen F Di Virgilio BN Cronstein PC Dagnelie 2006 Adenosine 5′-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation Pharmacol Ther 112 358 404
6. M Idzko H Hammad M van Nimwegen M Kool MA Willart F Muskens HC Hoogsteden W Luttmann D Ferrari F Di Virgilio JC Virchow Jr BN Lambrecht 2007 Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells Nat Med 13 913 919
7. J Leipziger 2003 Control of epithelial transport via luminal P2 receptors Am J Physiol Renal Physiol 284 419 432
8. T Hayashi M Kawakami S Sasaki T Katsumata H Mori H Yoshida T Nakahari 2005 ATP regulation of ciliary beat frequency in rat tracheal and distal airway epithelium Exp Physiol 90 535 544
9. - conductances J Gen Physiol 120 407 418
10. H Castrop Y Huang S Hashimoto D Mizel P Hansen F Theilig S Bachmann C Deng J Briggs J Schnermann 2004 Impairment of tubuloglomerular feedback regulation of GFR in ecto-5′-nucleotidase/CD73-deficient mice J Clin Invest 114 634 642
11. E Hamelmann J Schwarze K Takeda A Oshiba GL Larsen CG Irvin EW Gelfand 1997 Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography Am J Respir Crit Care Med 156 766 775
12. CC Lin 2001 Noninvasive method to measure airway obstruction in nonanesthetized allergen-sensitized and challenged mice Respiration 68 178 185
13. - secretion in mouse trachea Cell Physiol Biochem 16 99 108
14. H Zimmermann 2000 Extracellular metabolism of ATP and other nucleotides Naunyn-Schmiedebergs Arch Pharmacol 362 299 309
15. MR Knowles RC Boucher 2002 Mucus clearance as a primary innate defense mechanism for mammalian airways J Clin Invest 109 571 577
16. A Wanner M Salathe TG O'Riordan 1996 Mucociliary clearance in the airways Am J Respir Crit Care Med 154 1868 1902
17. P Forsythe M Ennis 1999 Adenosine, mast cells and asthma Inflamm Res 48 301 307
18. BM van den R Polosa HA Kerstjens DS Postma 2004 The role of endogenous and exogenous AMP in asthma and chronic obstructive pulmonary disease J Allergy Clin Immunol 114 737 746
19. DT Luttikhuizen MC Harmsen LF de Leij MJ van Luyn 2004 Expression of P2 receptors at sites of chronic inflammation Cell Tissue Res 317 289 298
20. GS Whitehead JK Walker KG Berman WM Foster DA Schwartz 2003 Allergen-induced airway disease is mouse strain dependent Am J Physiol Lung Cell Mol Physiol 285 L32 L42
21. N Mizumoto T Kumamoto SC Robson J Sevigny H Matsue K Enjyoji A Takashima 2002 CD39 is the dominant Langerhans cell-associated ecto-NTPDase: modulatory roles in inflammation and immune responsiveness Nat Med 8 358 365
22. 2+ signaling and control of growth and proliferation Biol Cell 96 55 68