Effectiveness of thoracic medial branch blocks in managing chronic pain: A preliminary report of a randomized, double-blind controlled trial; Clinical Trial NCT00355706

Pain Physician

Volumn 11, Issue 4, 2008, Pages 491-504

  Manchikanti, Laxmaiah ^a,d,f   Singh, Vijay ^b   Falco, Frank J E ^c,e   Cash, Kimberly A ^a   Pampati, Vidyasagar ^a  

^a PAIN MANAGEMENT CENTER OF PADUCAH   (United States)

^b Pain Diagnostics Associates   (United States)

^c Mid Atlantic Spine and Pain Physicians   (United States)

^d University of Louisville School of Medicine   (United States)

^e TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f NONE   (United States)

Author keywords

Chronic spinal pain; Comparative controlled local anesthetic blocks; Facet joint nerve or medial branch blocks; Therapeutic thoracic medial branch blocks; Thoracic facet or zygapophysial joint pain; Thoracic pain

Indexed keywords

BETAMETHASONE; BUPIVACAINE; LIDOCAINE; LOCAL ANESTHETIC AGENT; MIDAZOLAM; NARCOTIC ANALGESIC AGENT; STEROID;

ABSENCE OF SIDE EFFECTS; ADULT; ANALGESIA; ARTHRALGIA; ARTICLE; CHRONIC PAIN; CLINICAL ARTICLE; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; EMPLOYMENT; FEMALE; FUNCTIONAL ASSESSMENT; HUMAN; MALE; MONOTHERAPY; NERVE BLOCK; PAIN ASSESSMENT; PRIVATE PRACTICE; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; THORACIC SPINE; UNITED STATES; ZYGAPOPHYSEAL JOINT;

EID: 56549121080     PISSN: 15333159     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (90)

1. Manchikanti L, Schultz DM, Falco FJ, Singh V. Thoracic facet joint interventions. In Manchikanti L, Singh V (eds). Interventional Techniques in Chronic Spinal Pain, ASIPP Publishing, Paducah, KY, 2007; 277-294.
2. Manchikanti L, Pampati VS. Research designs in interventional pain management: Is randomization superior, desirable or essential? Pain Physician 2002; 5:275-284.
3. Stolker RJ, Vervest AC, Groen GJ. Percutaneous facet denervation in chronic thoracic spinal pain. Acta Neurochir 1993; 122:82-90.
4. Linton SJ, Hellsing AL, Hallden K. A population based study of spinal pain among 35-45-year-old individuals. Spine 1998; 23:1457-1463.
5. Wilson PR. Thoracic facet joint syndrome - a clinical entity? Pain Suppl 1987; 4:S87.
6. Dreyfuss P, Tibiletti C, Dreyer SJ. Thoracic zygapophyseal joint pain patterns: A study in normal volunteers. Spine 1994; 19:807-811.
7. Fukui S, Ohseto K, Shiotani M. Patterns of pain induced by distending the thoracic zygapophyseal joints. Reg Anesth 1997; 22:332-336.
8. Manchikanti L, Singh V, Pampati VS, Beyer CD, Damron KS. Evaluation of the prevalence of facet joint pain in chronic thoracic pain. Pain Physician 2002; 5:354-359.
9. Manchikanti L, Boswell MV, Singh V, Pampati VS, Damron KS, Beyer CD. Prevalence of facet joint pain in chronic spinal pain of cervical, thoracic, and lumbar regions. BMC Musculoskelet Disord 2004; 5:15.
10. Manchukonda R, Manchikanti KN, Cash KA, Pampati V, Manchikanti L. Facet joint pain in chronic spinal pain: An evaluation of prevalence and false-positive rate of diagnostic blocks. J Spinal Disord Tech 2007; 20:539-545.
11. Seghal N, Dunbar EE, Shah RV, Colson JD. Systematic review of diagnostic utility of facet (zygapophysial) joint injections in chronic spinal pain: An update. Pain Physician 2007; 10:213-228.
12. Boswell MV, Singh V, Staats PS, Hirsch JA. Accuracy of precision diagnostic blocks in the diagnosis of chronic spinal pain of facet or zygapophysial joint origin. Pain Physician 2003; 6:449-456.
13. Sehgal N, Shah RV, McKenzie-Brown A, Everett CR. Diagnostic utility of facet (zygapophysial) joint injections in chronic spinal pain: A systematic review of evidence. Pain Physician 2005; 8:211-224.
14. Merskey H, Bogduk N. Classification of 2 Chronic Pain. Descriptions of Chronic Pain Syndromes and Definition of Pain Terms, 2nd ed. International Association for the Study of Pain. IASP Press, Seattle, 1994.
15. Bogduk N. Low back pain. Clinical Anatomy of Lumbar Spine and Sacrum, 4th edition. Churchill Livingstone, New York, 2005, pp 183-216.
16. Stolker RJ, Vervest AC, Groen GJ. Parameters in electrode positioning in thoracic percutaneous facet denervation: An anatomical study. Acta Neurochir 1994; 128:32-39.
17. Stolker RJ, Vervest AC, Groen GJ. The treatment of chronic thoracic segmental pain by radiofrequency percutaneous partial rhizotomy. J Neurosurg 1994; 80:986-992.
18. Stolker RJ, Vervest AC, Ramos LM, Groen GJ. Electrode positioning in thoracic percutaneous partial rhizotomy: An anatomical study. Pain 1994; 57:241-251.
19. Dreyfuss P, Tibiletti C, Dreyer S. Sobel J. Thoracic zygapophyseal pain: A review and description of an intraarticular block technique. Pain Digest 1994; 4:44-52.
20. Chua WH, Bogduk N. The surgical anatomy of thoracic facet denervation. Acta Neurochir 1995; 136:140-144.
21. Stolker RJ, Vervest AC, Groen GJ, De Ruiter JW, Hansen L. On the innervation of the dorsal compartment of the thoracic spine. In Stolker RJ, Vervest AC (eds). Pain Management by Radiofrequency Procedures in the Cervical and Thoracic Spine: A Clinical and Anatomical Study. Utrecht, Thesis, 1994, pp 133-144.
22. Stilwell DL. The nerve supply of the vertebral column and its associated structures in the monkey. Anat Rec 1956; 125:139-169.
23. Bogduk N. International Spinal Injection Society guidelines for the performance of spinal injection procedures. Part 1: Zygapophyseal joint blocks. Clin J Pain 1997; 13:285-302.
24. Boswell MV, Trescot AM, Datta S, Schultz DM, Hansen HC, Abdi S, Sehgal N, Shah RV, Singh V, Benyamin RM, Patel VB, Buenaventura RM, Colson JD, Cordner HJ, Epter RS, Jasper JF, Dunbar EE, Atluri SL, Bowman RC, Deer TR, Hansen HC, Staats PS, Smith HS, Burton AW, Kloth DS, Giordano J, Manchikanti L. Interventional techniques: Evidence-based practice guidelines in the management of chronic spinal pain. Pain Physician 2007; 10:7-111.
25. Boswell MV, Colson JD, Sehgal N, Dunbar EE, Epter R. A systematic review of therapeutic facet joint interventions in chronic spinal pain. Pain Physician 2007; 10:229-254.
26. Manchikanti L, Singh V, Vilims BD, Hansen HC, Schultz DM, Kloth DS. Medial branch neurotomy in management of chronic spinal pain: Systematic review of the evidence. Pain Physician 2002; 5:405-418.
27. Manchikanti L, Manchikanti KN, Manchukonda R, Pampati V, Cash KA. Evaluation of therapeutic thoracic medial branch block effectiveness in chronic thoracic pain: A prospective outcome study with minimum 1-year follow up. Pain Physician 2006; 9:97-105.
28. Tzaan W, Tasker R. Percutaneous radiofrequency facet rhizotomy-experience with 118 procedures and reappraisal of its value. Can J Neurol Sci 2000; 27:125-130.
29. Manchikanti LM, Singh V, Falco FJE, Cash KM, Fellows B. Cervical medial branch blocks for chronic cervical facet joint pain: A randomized, double-blind, controlled trial with 1-year follow-up: Clinical Trial NCT0033272. Spine 2008; 33:1813-1820.
30. Manchikanti L, Damron KS, Cash KA, Manchukonda R, Pampati V. Therapeutic medial branch blocks in managing chronic neck pain: A preliminary report of a randomized, double-blind, controlled trial: Clinical Trial NCT0033272. Pain Physician 2006; 9:333-346.
31. Manchikanti L, Manchikanti KN, Damron KS, Pampati V. Effectiveness of cervical medial branch blocks in chronic neck pain: A prospective outcome study. Pain Physician 2004; 7:195-201.
32. Manchikanti L, Singh V, Falco FJ, Cash KA, Pampati V. Lumbar facet joint nerve blocks in managing chronic facet joint pain: One-year follow-up of a randomized, double-blind controlled trial: Clinical Trial NCT00355914. Pain Physician 2008; 11:121-132.
33. Lord SM, Barnsley L, Wallis BJ, McDonald GJ, Bogduk N. Percutaneous radiofrequency neurotomy for chronic cervical zygapophysial joint pain. N Engl J Med 1996; 335:1721-1726.
34. Barnsley L. Percutaneous radiofrequency neurotomy for chronic neck pain: Outcomes in a series of consecutive patients. Pain Med 2005; 6:282-286.
35. Moher D, Schulz KF, Altman D, for the CONSORT Group. The CONSORT statement: Revised recommendations for improving the quality of reports of parallel-group randomized trials. JAMA 2001; 285:1987-1991.
36. Fairbank JCT, Pynsent PB. The Oswestry Disability Index. Spine 2000; 25:2940-2953.
37. van Kleef M, Barendse GA, Kessels A, Voets HM, Weber WE, de Lange S. Randomized trial of radiofrequency lumbar facet denervation for chronic low back pain. Spine 1999; 24:1937-1942.
38. Koes BW, Scholten RJ, Mens JM, Bouter LM. Efficacy of epidural steroid injections for low-back pain and sciatica: A systematic review of randomized clinical trials. Pain 1995; 63:279-288.
39. Roland M, Torgerson DJ. What are pragmatic trials? BMJ 1998; 316:285.
40. Tunis SR, Stryer DB, Clancy CM. Practical clinical trials. Increasing the value of clinical research for decision making in clinical and health policy. JAMA 2003; 290:1624-32.
41. Shah RV, Kaye AD. Evolving concepts in the understanding of cervical facet joint pain. Pain Physician 2004; 7:295-299.
42. Freynhagen R, Rolke R, Baron R, Tölle TR, Rutjes AK, Schu S, Treede RD. Pseudoradicular and radicular low-back pain - a disease continuum rather than different entities? Answers from quantitative sensory testing. Pain 2008; 135:65-74.
43. Grenier B, Castagnera L, Maurette P, Erny P, Senegas J. Chronic cervico-brachial neuralgia treated by cervical epidural injection of corticosteroids. Longterm results. Ann Fr Anesth Reanim 1995; 14:484-488.
44. Hayashi N, Weinstein JN, Meller ST, Lee SM, Spratt KF, Gebhart GF. The effect of epidural injection of betamethasone or bupivacaine in a rat model of lumbar radiculopathy. Spine 1998; 23:877-885.
45. Lee HM, Weinstein JN, Meller ST, Hayashi N, Spratt KF, Gebhart GF. The role of steroids and their effects on phospholipase A2. An animal model of radiculopathy. Spine 1998; 23:1191-1196.
46. Johansson A, Hao J, Sjolund B. Local corticosteroid application blocks transmission in normal nociceptive C-fibres. Acta Anaesthesiol Scand 1990; 34:335-338.
47. Pasqualucci A, Varrassi G, Braschi A, Peduto VA, Brunelli A, Marinangeli F, Gori F, Colò F, Paladín A, Mojoli F. Epidural local anesthetic plus corticosteroid for the treatment of cervical brachial radicular pain: Single injection verus continuous infusion. Clin J Pain 2007; 23:551-557.
48. Katz WA, Rothenberg R. The nature of pain: Pathophysiology. J Clin Rheumatol 2005; 11(2 suppl):S11-15.
49. Melzack R, Coderre TJ, Katz J, Vaccarino AL. Central neuroplasticity and pathological pain. Ann N Y Acad Sci 2001; 933:157-174.
50. Kawakami M, Weinstein JN, Chatani K, Spratt KF, Meller ST, Gebhart GF. Experimental lumbar radiculopathy. Behavioral and histologic changes in a model of radicular pain after spinal nerve root irritation with chromic gut ligatures in the rat. Spine 1994; 19:1795-1802.
51. Decosterd I, Woolf CJ. Spared nerve injury: An animal model of persistent peripheral neuropathic pain. Pain 2000; 87:149-158.
52. Pennypacker KR, Hong JS, McMillian MK. Implications of prolonged expression of Fos-related antigens. Trends Pharmacol Sci 1995; 16:317-321.
53. Ji RR, Woolf CJ. Neuronal plasticity and signal transduction in nociceptive neurons: Implications for the initiation and maintenance of pathological pain. Neurobiol Dis 2001; 8:1-10.
54. Mao J, Chen LL. Systemic lidocaine for neuropathic pain relief. Pain 2000; 87:7-17.
55. Pasqualucci A. Experimental and clinical studies about the preemptive analgesia with local anesthetics. Possible reasons of the failure. Minerva Anestesiol 1998; 64:445-457.
56. Ferrante FM, Paggioli J, Cherukuri S, Arthru GR. The analgesic response to intravenous lidocaine in the treatment of neuropathic pain. Anesth Analg 1996; 82:91-97.
57. Arner S, Lindblom U, Meyerson BA, Molander C. Prolonged relief of neuralgia after regional anesthetic block. A call for further experimental and systematic clinical studies. Pain 1990; 43:287-297.
58. Lavoie PA, Khazen T, Filion PR. Mechanisms of the inhibition of fast axonal transport by local anesthetics. Neuropharmacology 1989; 28:175-181.
59. Bisby MA. Inhibition of axonal transport in nerves chronically treated with local anesthetics. Exp Neurol 1975; 47:481-489.
60. Benzon HT. Epidural steroid injections for low back pain and lumbosacral radiculopathy. Pain 1986; 24:277-295.
61. Cassuto J, Sinclair R, Bonderovic M. Anti-inflammatory properties of local anesthetics and their present and potential clinical implications. Acta Anaesthesiol Scand 2006; 50:265-282.
62. Wertheim HM, Rovenstine EA. Suprascapular nerve block. Anesthesiology 1941; 2:541.
63. Riew KD, Park JB, Cho YS, Gilula L, Patel A, Lente LG, Bridwell KH. Nerve root blocks in the treatment of lumbar radicular pain. A minimum five-year follow-up. J Bone Joint Surg Am 2006; 88:1722-1725.
64. Riew KD, Yin Y, Gilula L, Bridwell KH, Lente LG, Lauryssen C, Goette K. The effect of nerve-root injections on the need for operative treatment of lumbar radicular pain. A prospective, randomized, controlled, double-blind study. J Bone Joint Surg Am 2000; 82-A:1589-1593.
65. Abram SE, Likavec MJ. Pain syndromes and rationale for management. Neurogenic pain. In Raj P (ed). Practical Management of Pain. Year Book Medical Publishers, Chicago, 1986, pp 182-191.
66. Bonica JJ. The Management of Pain. Lea and Febiger, Philadelphia, 1963.
67. Bonica JJ. Current role of nerve blocks in diagnosis and therapy of pain. In Bonica JJ (ed.) Advances in Neurology, Vol. 4. Raven Press, New York, 1974, pp 445-453.
68. Livingston WK. Pain Mechanisms. Macmillan, New York, 1943.
69. Raj PP. Prognostic and therapeutic local anaesthetic blockade. In Cousins MJ, Bridenbaugh PO (eds). Neural Blockade. Lippincott, Philadelphia, 1988, pp 900-901.
70. Kibler RF, Nathan PW. Relief of pain and paraesthesiae by nerve block distal to a lesion. J Neurol Neurosurg Psychiat 1960; 23:91-98.
71. Xavier AV, McDanal J, Kissin I. Relief of sciatic radicular pain by sciatic nerve block. Anesth Analg 1988; 67:1177-1180.
72. Manchikanti L, Pampati V, Fellows B, Bakhit CE. The diagnostic validity and therapeutic value of lumbar facet joint nerve blocks with or without adjuvant agents. Curr Rev Pain 2000; 4:337-344.
73. Manchikanti KN, Pampati V, Damron KS, McManus CD. A double-blind, controlled evaluation of the value of Sarapin in neural blockade. Pain Physician 2004; 7:59-62.
74. Sato C, Sakai A, Ikeda Y, Suzuki H, Sakamoto A. The prolonged analgesic effect of epidural ropivacaine in a rat model of neuropathic pain. Anesth Analg 2008; 106:313-320.
75. Tachihara H, Sekiguchi M, Kikuchi S, Konno S. Do corticosteroids produce additional benefit in nerve root infiltration for lumbar disc herniation. Spine 2008; 33:743-747.
76. Yabuki S, Kikuchi S, Olmarker K, Myers RR. Acute effects of nucleus pulposus on blood flow and endoneurial fluid pressure in rat dorsal root ganglia. Spine 1998; 23:2517-2523.
77. Myers RR, Mizisin AP, Powell HC, Lampert PW. Reduced nerve blood flow in hexachlorophene neuropathy. J Neuropath Exp Neurol 1982; 41:391-399.
78. Myers RR, Powell Hc, Costello ML, Lampert PW, Zweifach BW. Endoneurial fluid pressure: Direct measurement with micropipettes. Brain Res 1978; 148:510-515.
79. Onda A, Yabuki S, Kikuchi S, Satoh K, Myers RR. Effects of lidocaine on blood flow and endoneurial fluid pressure in a rat model of herniated nucleus pulposus. Spine 2001; 26:2186-2191.
80. Yabuki S, Kikuchi S. Nerve root infiltration and sympathetic block: An experimental study of intraradicular blood flow. Spine 1995; 20:901-906.
81. Ohtori S, Inoue G, Koshi T, Ito T, Doya H, Saito T, Moriya H, Takahashi K. Upregulation of acid-sensing ion channel 3 in dorsal root ganglion neurons following application of nucleus pulposus on nerve root in rats. Spine 2006; 31:2048-2052.
82. Hasue M. Pain and the nerve root. Spine 1993; 18:2053-2058.
83. Bendrups A, Hilton A, Meager A, Hamilton JA. Reduction of tumor necrosis factor alpha and interleukin-1 beta levels in human synovial tissue by interleukin-4 and glucocorticoid. Rheumatol Int 1993; 12:217-220.
84. Kantrowitz F, Robinson DR, McGuire MDB. Corticosteroids inhibit prostaglandin production by rheumatoid synovia. Nature 1975; 258:737.
85. Saal JS, Franson RC, Dobrow R, Saal JA, White AH, Goldthwaite N. High levels of inflammatory phospholipase A2 activity in lumbar disc herniations. Spine 1990; 15:674-678.
86. Byrod G, Otani K, Brisby H, Rydevik B, Olmarker K. Methylprednisolone reduces the early vascular permeability increases in spinal nerve roots induced by epidural nucleus application. J Orthop Res 2000; 18:983-987.
87. Mackinnon SE, Hudson AR, Gentili F, Kline DG, Hunter D. Peripheral nerve injection injury with steroid agents. Plast Reconstr Surg 1982; 69:482-489.
88. Minamide A, Tamaki T, Hashizume H, Yoshida M, Kawakami M, Hayashi N. Effects of steroid and lipopolysaccharide on spontaneous resorption of herniated intervertebral discs: An experimental study in the rabbit. Spine 1998; 23:870-876.
89. Shishido H, Kikuchi S, Heckman H, Myers RR. Dexamethasone decreases blood flow in normal nerves and dorsal root ganglia. Spine 2002; 27:581-586.
90. Manchikanti L. Pharmacology of neuraxial steroids. In Manchikanti L, Singh V (eds). Interventional Techniques in Chronic Spinal Pain, ASIPP Publishing, Paducah, KY, 2007; 167-184.