Maternal tolerance achieved during pregnancy is transferred to the offspring via breast milk and persistently protects the offspring from allergic asthma

Clinical and Experimental Allergy

Volumn 38, Issue 12, 2008, Pages 1950-1958

  Polte, T ^a,b   Hansen, G ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Asthma; Pregnancy; Primary prevention; Tolerance

Indexed keywords

IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; OVALBUMIN;

ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST MILK; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; IMMUNE RESPONSE; IMMUNIZATION; MOUSE; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROGENY;

ALLERGENS; ANIMALS; ANIMALS, SUCKLING; ANTIBODIES; ANTIBODY SPECIFICITY; ANTIGENS; ASTHMA; DISEASE MODELS, ANIMAL; FEMALE; IMMUNE TOLERANCE; IMMUNITY, MATERNALLY-ACQUIRED; IMMUNIZATION; IMMUNOGLOBULIN G; MICE; MICE, INBRED BALB C; MILK, HUMAN; OVALBUMIN; PREGNANCY;

EID: 56549103486     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2008.03096.x     Document Type: Article

References (34)

1. Ball TM, Castro-Rodriguez JA, Griffith KA, Holberg CJ, Martinez FD, Wright AL. Siblings, day-care attendance, and the risk of asthma and wheezing during childhood. N Engl J Med 2000 343 : 538 43.
2. Celedon JC, Wright RJ, Litonjua AA et al. Day care attendance in early life, maternal history of asthma, and asthma at the age of 6 years. Am J Respir Crit Care Med 2003 167 : 1239 43.
3. Illi S, von Mutius E, Lau S et al. The pattern of atopic sensitization is associated with the development of asthma in childhood. J Allergy Clin Immunol 2001 108 : 709 14.
4. Hay FC, Hull MG, Torrigiani G. The transfer of human IgG subclasses from mother to foetus. Clin Exp Immunol 1971 9 : 355 8.
5. Jones CA, Holloway JA, Warner JO. Fetal immune responsiveness and routes of allergic sensitization. Pediatr Allergy Immunol 2002 13 (Suppl. 15) : 19 22.
6. Ege MJ, Bieli C, Frei R et al. Prenatal farm exposure is related to the expression of receptors of the innate immunity and to atopic sensitization in school-age children. J Allergy Clin Immunol 2006 117 : 817 23.
7. Stern DA, Riedler J, Nowak D et al. Exposure to a farming environment has allergen-specific protective effects on Th2-dependent isotype switching in response to common inhalants. J Allergy Clin Immunol 2007 119 : 351 8.
8. Piccinni MP, Mecacci F, Sampognaro S et al. Aeroallergen sensitization can occur during fetal life. Int Arch Allergy Immunol 1993 102 : 301 3.
9. Ruiz RG, Kemeny DM, Price JF. Higher risk of infantile atopic dermatitis from maternal atopy than from paternal atopy. Clin Exp Allergy 1992 22 : 762 6.
10. Gerhold K, Avagyan A, Seib C et al. Prenatal initiation of endotoxin airway exposure prevents subsequent allergen-induced sensitization and airway inflammation in mice. J Allergy Clin Immunol 2006 118 : 666 73.
11. Pincus-Knackstedt MK, Joachim RA, Blois SM et al. Prenatal Stress Enhances Susceptibility of Murine Adult Offspring toward Airway Inflammation. J Immunol 2006 177 : 8484 92.
12. Hansen G, Berry G, DeKruyff RH, Umetsu DT. Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. J Clin Invest 1999 103 : 175 83.
13. Polte T, Foell J, Werner C et al. CD137-mediated immunotherapy for allergic asthma. J Clin Invest 2006 116 : 1025 36.
14. Polte T, Behrendt AK, Hansen G. Direct evidence for a critical role of CD30 in the development of allergic asthma. J Allergy Clin Immunol 2006 118 : 942 8.
15. Kramer MS, Chalmers B, Hodnett ED et al. Promotion of Breastfeeding Intervention Trial (PROBIT): a randomized trial in the Republic of Belarus. JAMA 2001 285 : 413 0.
16. Oddy WH, Peat JK, de Klerk NH. Maternal asthma, infant feeding, and the risk of asthma in childhood. J Allergy Clin Immunol 2002 110 : 65 7.
17. Kull I, Almqvist C, Lilja G, Pershagen G, Wickman M. Breast-feeding reduces the risk of asthma during the first 4 years of life. J Allergy Clin Immunol 2004 114 : 755 60.
18. Sears MR, Greene JM, Willan AR et al. Long-term relation between breastfeeding and development of atopy and asthma in children and young adults: a longitudinal study. Lancet 2002 360 : 901 7.
19. Bergmann RL, Diepgen TL, Kuss O et al. Breastfeeding duration is a risk factor for atopic eczema. Clin Exp Allergy 2002 32 : 205 9.
20. Zinkernagel RM. Maternal antibodies, childhood infections, and autoimmune diseases. N Engl J Med 2001 345 : 1331 5.
21. Weil GJ, Hussain R, Kumaraswami V, Tripathy SP, Phillips KS, Ottesen EA. Prenatal allergic sensitization to helminth antigens in offspring of parasite-infected mothers. J Clin Invest 1983 71 : 1124 9.
22. Holt P, Naspitz C, Warner JO. Early immunological influences. Chem Immunol Allergy 2004 84 : 102 27.
23. Holloway JA, Warner JO, Vance GH, Diaper ND, Warner JA, Jones CA. Detection of house-dust-mite allergen in amniotic fluid and umbilical-cord blood. Lancet 2000 356 : 1900 2.
24. Van Duren-Schmidt K, Pichler J, Ebner C et al. Prenatal contact with inhalant allergens. Pediatr Res 1997 41 : 128 31.
25. Szepfalusi Z, Nentwich I, Gerstmayr M et al. Prenatal allergen contact with milk proteins. Clin Exp Allergy 1997 27 : 28 35.
26. Prescott SL, Macaubas C, Holt BJ et al. Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T cell responses toward the Th2 cytokine profile. J Immunol 1998 160 : 4730 7.
27. Leme AS, Hubeau C, Xiang Y et al. Role of breast milk in a mouse model of maternal transmission of asthma susceptibility. J Immunol 2006 176 : 762 9.
28. Verhasselt V, Milcent V, Cazareth J et al. Breast milk-mediated transfer of an antigen induces tolerance and protection from allergic asthma. Nat Med 2008 14 : 170 5.
29. Jarrett E, Hall E. Selective suppression of IgE antibody responsiveness by maternal influence. Nature 1979 280 : 145 7.
30. Seeger M, Thierse HJ, Lange H, Shaw L, Hansen H, Lemke H. Antigen-independent suppression of the IgE immune response to bee venom phospholipase A2 by maternally derived monoclonal IgG antibodies. Eur J Immunol 1998 28 : 2124 30.
31. Uthoff H, Spenner A, Reckelkamm W et al. Critical role of preconceptional immunization for protective and nonpathological specific immunity in murine neonates. J Immunol 2003 171 : 3485 92.
32. Simister NE. Placental transport of immunoglobulin G. Vaccine 2003 21 : 3365 9.
33. Jenmalm MC, Van Snick J, Cormont F, Salman B. Allergen-induced Th1 and Th2 cytokine secretion in relation to specific allergen sensitization and atopic symptoms in children. Clin Exp Allergy 2001 31 : 1528 35.
34. Glovsky MM, Ghekiere L, Rejzek E. Effect of maternal immunotherapy on immediate skin test reactivity, specific rye I IgG and IgE antibody, and total IgE of the children. Ann Allergy 1991 67 : 21 4.