Phase contrast X-ray imaging for the non-invasive detection of airway surfaces and lumen characteristics in mouse models of airway disease

European Journal of Radiology

Volumn 68, Issue 3 SUPPL., 2008, Pages S22-S26

  Siu, K K W ^a   Morgan, K S ^a   Paganin, D M ^a   Boucher, R ^b   Uesugi, K ^c   Yagi, N ^c   Parsons, D W ^d,e,f  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c JAPAN SYNCHROTRON RADIATION RESEARCH INSTITUTE   (Japan)

^d WOMEN S AND CHILDREN S HOSPITAL   (Australia)

^e UNIVERSITY OF ADELAIDE   (Australia)

^f Women's and Children's Health Research Institute   (Australia)

Author keywords

Airway surface; Computed tomography; Cystic fibrosis; Phase contrast imaging; Synchrotron

Indexed keywords

BIOLOGICAL ORGANS; DIAGNOSIS; DISEASE CONTROL; MAMMALS; SYNCHROTRONS; X RAY ANALYSIS;

AIRWAY SURFACES; CYSTIC FIBROSIS; PHARMACEUTICAL THERAPIES; PHASE CONTRAST X-RAY IMAGING; PHASE-CONTRAST IMAGING; STRUCTURE-FUNCTION RELATIONSHIP; THERAPEUTIC INTERVENTION; THREE DIMENSIONAL (3-D) IMAGING;

COMPUTERIZED TOMOGRAPHY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL MONITORING; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DIAGNOSTIC IMAGING; EXPERIMENTAL MODEL; GENE THERAPY; LUNG FIBROSIS; MOUSE; NON INVASIVE MEASUREMENT; NONHUMAN; NOSE; PHASE CONTRAST X RAY IMAGING; PRIORITY JOURNAL; SIMULATION; THREE DIMENSIONAL IMAGING; TRACHEA;

EID: 56549100876     PISSN: 0720048X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejrad.2008.04.029     Document Type: Article

References (15)

1. Roomans G.M., Kozlova I., Nilsson H., et al. Measurements of airway surface liquid height and mucus transport by fluorescence microscopy, and of ion composition by X-ray microanalysis. J. Cyst. Fibros. 3 Suppl 2 (2004) 135-139
2. Koldej R., Cmielewski P., Stocker A., et al. Optimisation of a multipartite human immunodeficiency virus based vector system; control of virus infectivity and large-scale production. J. Gene Med. 7 (2005) 1390-1399
3. Limberis M., Anson D.S., Fuller M., et al. Recovery of airway cystic fibrosis transmembrane conductance regulator function in mice with cystic fibrosis after single-dose lentivirus-mediated gene transfer. Hum. Gene Ther. 13 (2002) 1961-1970
4. Song Y., Thiagarajah J., and Verkman A.S. Sodium and chloride concentrations, pH, and depth of airway surface liquid in distal airways. J. Gen. Physiol. 122 (2003) 511-519
5. Tarran R., Grubb B.R., Parsons D., et al. The CF salt controversy: in vivo observations and therapeutic approaches. Mol. Cell 8 (2001) 149-158
6. Parsons D.W., Hopkins P.J., Bourne A.J., et al. Airway gene transfer in mouse nasal-airways: importance of identification of epithelial type for assessment of gene transfer. Gene Ther. 7 (2000) 1810-1815
7. Lewis R.A. Medical phase contrast X-ray imaging: current status and future prospects. Phys. Med. Biol. 49 (2004) 3573-3583
8. Wilkins S.W., Gureyev T.E., Gao D., et al. Phase-contrast imaging using polychromatic hard X-rays. Nature 384 (1996) 338-1338
9. Suzuki Y., Yagi N., and Uesugi K. X-ray refraction-enhanced imaging and a method for phase retrieval for a simple object. J. Synchrotron Radiat. 9 (2002) 160-165
10. Snigirev A., Snigireva I., Kohn V., et al. On the possibilities of X-ray phase contrast microimaging by coherent high-energy synchrotron radiation. Rev. Sci. Instrum. 66 (1995) 5486-5492
11. Cloetens P., Ludwig W., Baruchel J., et al. Holotomography: quantitative phase tomography with micrometer resolution using hard synchrotron radiation X-rays. Appl. Phys. Lett. 75 (1999) 2912-2914
12. Gureyev T.E., Paganin D.M., Myers G.R., et al. Phase-and-amplitude computer tomography. Appl. Phys. Lett. 89 (2006) 034101-034102
13. Daviskas E., and Anderson S.D. Hyperosmolar agents and clearance of mucus in the diseased airway. J. Aerosol Med. 19 (2006) 100-109
14. Rodwell L.T., and Anderson S.D. Airway responsiveness to hyperosmolar saline challenge in cystic fibrosis: a pilot study. Pediatr. Pulmonol. 21 (1996) 282-289
15. Mery S., Gross E.A., Joyner D.R., et al. Nasal diagrams: a tool for recording the distribution of nasal lesions in rats and mice. Toxicol. Pathol. 22 (1994) 353-372