hLH/hCG-receptor expression correlates with in vitro invasiveness in human primary endometrial cancer

Gynecologic Oncology

Volumn 111, Issue 3, 2008, Pages 496-501

  Noci, Ivo ^a   Pillozzi, Serena ^a   Lastraioli, Elena ^a   Dabizzi, Sara ^a   Giachi, Massimo ^a   Borrani, Elena ^a   Wimalasena, Jay ^b   Taddei, Gian Luigi ^a   Scarselli, Gianfranco ^a   Arcangeli, Annarosa ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF TENNESSEE   (United States)

Author keywords

Endometrial cancer; hLH hCG receptor; Invasiveness

Indexed keywords

CHORIONIC GONADOTROPIN RECEPTOR; GONADORELIN DERIVATIVE; LUTEINIZING HORMONE; LUTEINIZING HORMONE RECEPTOR; MESSENGER RNA;

ADULT; AGED; ARTICLE; CANCER INVASION; CELL INVASION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENDOMETRIUM CANCER; FEMALE; HORMONE RESPONSE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AGED; AGED, 80 AND OVER; COHORT STUDIES; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LUTEINIZING HORMONE; MIDDLE AGED; NEOPLASM INVASIVENESS; POLYMERASE CHAIN REACTION; RECEPTORS, LH; RNA, MESSENGER;

EID: 56449106565     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2008.08.018     Document Type: Article

References (22)

1. Wingo P.A., Ries L.A.G., Giovino G.A., Miller D.S., Rosenberg H.M., Shopland D.R., et al. Annual report to the nation on the status of cancer, 1973-1996. J Natl Cancer Inst (Bethesda) 91 (1999) 675-690
2. Deligdisch L., and Holinka C.F. Endometrial carcinoma: two diseases?. Cancer Detect Prev 10 (1987) 237-246
3. Lin J., Lei Z.M., Lojun S., Rao C.V., Satyaswaroop P.G., and Day T.G. Increased expression of luteinizing hormone/human chorionic gonadotropin receptor gene in human endometrial carcinomas. J Clin Endocrinol Metab 79 (1994) 1483-1491
4. Pike M.C., Peters R.K., Cozen W., Pobst-Hensch N.M., Felix J.C., Wan P., et al. Estrogen-progestin replacement therapy and endometrial cancer. J Natl Cancer Inst (Bethesda) 89 (1997) 1110-1111
5. Davies S., Bax C.M.R., Chatzaki E., Chard T., and Iles R.K. Regulation of endometrial cancer cell growth by luteinizing hormone (LH) and follicle stimulating hormone (FSH). Br J Cancer 83 (2000) 1730-1734
6. Lhomme C., Vennin P., Callet N., Lesimple T., Achard J.L., Chauvergne J., et al. A multicenter phase II study with triptorelin (sustained-release LHRH agonist) in advanced or recurrent endometrial carcinoma: a French anticancer federation study. Gynecol Oncol 75 (1999) 187-193
7. Jeyarajah A.R., Gallagher C.J., Blake P.R., Oram D.H., Dowsett M., Fisher C., et al. Long-term follow-up of gonadotrophin-releasing hormone analog treatment for recurrent endometrial cancer. Gynecol Oncol 63 (1996) 47-52
8. Covens A., Thomas G., Shaw P., Ackerman I., Osborne R., Lukka H., et al. A phase II study of leuprolide in advanced/recurrent endometrial cancer. Gynecol Oncol 64 (1997) 126-129
9. Markman M., Kennedy A., Webster K., Peterson G., Kulp B., and Belinson J. Leuprolide in the treatment of endometrial cancer. Gynecol Oncol 66 (1997) 542
10. Asbury R.F., Brunetto V.L., Lee R.B., Reid G., Rovereto T.F., and Gynecologic Oncology Group. Goserelin acetate as treatment for recurrent endometrial carcinoma: a Gynecologic Oncology Group study. Am J Clin Oncol 25 (2002) 557-560
11. Noci I., Borri P., Bonfirraro G., Chieffi O., Arcangeli A., Cherubini A., et al. Longstanding survival without cancer progression in a patient affected by endometrial carcinoma treated primarily with leuprolide. Br J Cancer 85 (2001) 333-336
12. Dabizzi S., Noci I., Borri P., Borrani E., Giachi M., Balzi M., et al. Luteinizing hormone increases human endometrial cancer cells invasiveness through activation of protein kinase A. Cancer Res 63 (2003) 4281-4286
13. Viswanath G., Chatterjee S., and Roy P. Assessment of luteinizing hormone receptor function in an endometrial cancer cell line, Ishikawa cells in response to human chorionic gonadotrophin (hCG). Mol Cell Endocrinol 272 (2007) 14-21
14. Noci I., Coronnello M., Borri P., Borrani E., Giachi M., Chieffi O., et al. Inhibitory effect of luteinising hormone-releasing hormone analogues on human endometrial cancer in vitro. Cancer Lett 150 (2000) 71-78
15. Crociani O., Guasti L., Balzi M., Becchetti A., Wanke E., Olivotto M., et al. Cell cycle-dependent expression of HERG1 and HERG1B isoforms in tumor cells. J Biol Chem 278 (2003) 2947-2955
16. Hipkin R.W., Sánchez-Yagüe J., and Ascoli M. Identification and characterization of a luteinizing hormone/chorionic gonadotropin (LH/CG) receptor precursor in a human kidney cell line stably transfected with the rat luteal LH/CG receptor complementary DNA. Mol Endocrinol 6 (1992) 2210-2218
17. VuHai-LuuThi M.T., Misrahi M., Houllier A., Jolivet A., and Milgrom E. Variant forms of the pig lutropin/choriogoadotropin receptor. Biochemistry 31 (1992) 8377-8383
18. Apaja P.M., Aatsinki J.T., Rajaniemi H.J., and Petäjä-Repo U.E. Expression of the mature luteinizing hormone receptor in rodent urogenital and adrenal tissues is developmentally regulated at the posttranslational level. Endocrinology 146 (2005) 3224-3232
19. Pietilä E.M., Tuusa J.T., Apaja P.M., Aatsinki J.T., Hakalahti A.E., Rajanemi H.J., et al. Inefficient maturation of the rat luteinizing hormone receptor. A putative way to regulate receptor numbers at the cell surface. J Biol Chem 280 (2005) 26622-26629
20. Rao C.V. No mRNAs for the LH/hCG receptor in human endometrium?. Fertil Steril 72 (1999) 374-375
21. Ji Q., Chen P., Aoyoma C., and Liu P. Increased expression of human luteinizing hormone/human chorionic gonadotropin receptor mRNA in human endometrial cancer. Mol. Cell. Probes 16 (2002) 269-275
22. Berndt S., Perrier d'Hauterive S., Blacher S., Pèqueux C., Lorquet S., Munaut C., et al. Angiogenic activity of human chorionic gonadotropin through LH receptor activation. FASEB J 20 (2006) 2630-2632