A validated method for the quantitation of 1,1-difluoroethane using a gas in equilibrium method of calibration

Journal of Analytical Toxicology

Volumn 32, Issue 8, 2008, Pages 680-687

  Avella, Joseph ^a,b,c   Lehrer, Michael ^b   Zito, S William ^a  

^a ST JOHN'S UNIVERSITY   (United States)

^b U S DEPARTMENT OF HEALTH AND HUMAN SERVICES   (United States)

^c Suffolk County Medical Examiner's Office   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,1 DIFLUOROETHANE; ETHANE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD ANALYSIS; BRAIN TISSUE; CALIBRATION; CHEMICAL STRUCTURE; CONTROLLED STUDY; GAS CHROMATOGRAPHY; HUMAN; NONHUMAN; RAT; TEMPERATURE SENSITIVITY; URINALYSIS; VALIDATION PROCESS;

EID: 56449094178     PISSN: 01464760     EISSN: 01464760     Source Type: Journal    
DOI: 10.1093/jat/32.8.680     Document Type: Article

References (16)

1. Office of Applied Studies. Results from the 2005 National Survey on Drug Use and Health: National Findings (DHHS) Publication No. SMA 06-4194, NSDUH Series H-30. Substance and Mental Health Services Administration, Rockville, MD.
2. National Inhalant Prevention Coalition. Guidelines for Medical Examiners, Coroners and Pathologists: Determining Inhalant Deaths. http://www.inhalants. org/final_medical.htm, March 2006.
3. M.J. Beckstead, J.L. Weiner, E.I. Eger, D.H. Gong, and S.J. Mihic. Glycine and γ-aminobutyric acidA receptor function is enhanced by inhaled drugs of abuse. Mol. Pharmacol. 57: 1199-1205 (2000).
4. C.N. Connolly and K.A. Wafford. The Cys-loop superfamily of ligand gated ion channels: the impact of receptor structure on function. Biochem. Soc. Trans. 32: 529-534 (2004).
5. R.L. Balster. Neural basis of inhalant abuse. Drug Alcohol Depend. 51: 207-214 (1998).
6. L.A. Broussard, T. Brustowicz, T. Pittman, K.D. Atkins, and L. Presley. Two traffic fatalities related to the use of difluoroethane. J. Forensic Sci. 42: 1186-1187 (1997).
7. T. Hahn, J. Avella, and M. Lehrer. A motor vehicle accident involving the inhalation of 1,1-difluoroethane. J. Anal. Toxicol. 30: 638-642 (2006).
8. R.T. Shepherd. Mechanism of sudden death associated with volatile substance abuse. Hum. Toxicol. 8: 287-297 (1989).
9. Ellenhorn's Medical Toxicology: Diagnosis and Treatment of Human Poisoning, 2nd ed., M.J. Ellenhorn, Ed. Williams & Wilkins, Baltimore, MD, 1997, pp 1172-1173.
10. J. Avella, T. Hahn, and M. Lehrer. Postmortem distribution of 1, 1-difluoroethane in four cases. Proceedings of the SOFT Annual Meeting, 2006, Austin TX. SOFT Austin P-54.
11. L.A. Broussard, A. Broussard, T. Pittman, D. Lafferty, and L. Presley. Headspace gas chromatographic method for the measurement of difluoroethane in blood. Clin. Lab. Sci. 14: 3-5 (2001).
12. J. Avella, J.C. Wilson, and M. Lehrer. Fatal cardiac arrhythmia after repeated exposure to 1,1-difluoroethane (DFE). Am. J. Forensic Med. Pathol. 27: 58-60 (2006).
13. K.M. Cooper, S.F. Chang, and L.I. Harrison. Determination of the chlorofluorocarbon substitute 1,1,1,2-tetrafluoroethane in human and animal blood using gas chromatography with headspace analysis. J. Chromatogr. B 667: 85-93 (1995).
14. General Chemistry, 3rd ed., D.D. Ebbing, Ed. Houghton Mifflin, Boston, MA, 1990, pp 44 and 152-156.
15. S.A. Glantz. Primer of Biostatistics, 6th ed. McGraw-Hill, New York, NY, 2005, p 52.
16. United States Environmental Protection Agency. Phaseout schedule for HCFCs including R-22, http://www.epa.gov/Ozone/title6/phaseout/22phasout.html, March 2008.