Lanthanide Enhanced Luminescence (LEL) with one and two photon excitation of Quantum Dyes® Lanthanide(III)-Macrocycles

Proceedings of SPIE - The International Society for Optical Engineering

Volumn 5322, Issue , 2004, Pages 187-199

  Leif, Robert C ^a   Becker, Margie C ^b   Bromm Jr , Al ^c   Chen, Nanguang ^d   Cowan, Ann E ^e   Vallarino, Lidia M ^c   Yang, Sean ^a,b   Zucker, Robert M ^f  

^a Newport Instruments   (United States)

^b Phoenix Flow Systems   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^d UNIVERSITY OF CONNECTICUT   (United States)

^e UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^f U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Cofluorescence; Digital microscopy; Europium; Isothiocyanate; Lanthanide; LEL; Luminescence; Macrocycle; Solid phase; Terbium

Indexed keywords

CELLS; CYTOLOGY; DYES; EUROPIUM; GELATION; LUMINESCENCE; PHOSPHORS; PHOTONS; QUANTUM THEORY; TERBIUM;

DIGITAL MICROSCOPY; ISOTHIOCYNATE; LEL; MACROCYCLES; SOLID PHASE;

RARE EARTH ELEMENTS;

EID: 5644297241     PISSN: 0277786X     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.530284     Document Type: Conference Paper

References (16)

1. A. J. Bromm Jr., R. C. Leif, J. R. Quagliano, and L. M. Vallarino, The Addition of a Second Lanthanide Ion to Increase the Luminescence of Europium(III) Macrocyclic Complexes, Proceedings of Optical Diagnostics of Living Cells II, D. L. Farkas, R. C. Leif, B. J. Tromberg, Editors, SPIE Progress in Biomedical Optics, A. Katzir series Editor, Vol. 3604, ISBN 0-8194-3074-9, pp. 263-272, 1999.
2. R. C. Leif and L. M. Vallarino, US Patent 6,340,744, A Reagent System and Method for Increasing the Luminescence of Lanthanide(III) Macrocyclic Complexes, 2002, and United States Patent Application 20020132992, September 19, 2002.
3. J. R. Quagliano, R. C. Leif, L. M. Vallarino, and S. A. Williams, Methods to Increase the Luminescence of Lanthanide(III) Macrocyclic Complexes, Optical Diagnostics of Living Cells III, D. L. Farkas and R. C. Leif, Editors, SPIE Proceedings, Vol. 3921, pp. 124-133, 2000.
4. D. A. Zarling, M. Rossi, N. A. Peppers, J. Kane, G. W. Paris, M. J. Dyer, S. Y. Ng, and L. V. Schneider, U.S. Patent 5,698,397, Up-Converting Reporters for Biological and Other Assays Using Laser Excitation Techniques, 1997.
5. K. W. Kardos, R. S. Niedbala, J. L. Burton, D. E. Cooper, D. A. Zarling, M. Rossi, N. A. Peppers, J. Kane, G. W. Faris, M. J. Dyer, S. Y. Ng, and L. V. Schneider, US 6,159,686, Up-Converting Reporters for Biological and Other Assays Using Laser Excitation Techniques, 2000.
6. ABSOLUTE-S™ Protocol, Phoenix How Systems, 6790 Top Gun St., Suite 1, San Diego, CA 92121-4121, Tel. (858) 453-5095; http://www.phnxflow.com.
7. R. C. Leif, Methods for Preparing Sorted Cells as Monolayer Specimens, In Living Color, Protocols in Flow Cytometry and Cell Sorting, R. A. Diamond and S. DeMaggio, Editors, Springer, ISBN 3-540-65149-7, pp. 592-619, 2000.
8. R. M Zucker and O. T. Price, Evaluation of confocal system performance, Cytometry Vol. B44, pp. 273-294, 2001.
9. R.C. Leif, M.C. Becker, L.M. Vallarino, J.W. Williams, and S. Yang, Progress in the Use of Quantum Dye® Eu(III)-Macrocycles, Manipulation and Analysis of Biomolecules, Cells and Tissues, D. V. Nicolau, J. Enderlein, and R. C. Leif, Editors, SPIE Proceedings, Vol. 4962, pp. 341-353, 2003.
10. X. Li, F. Traganos, M. R. Melamed, and Z. Darzynkiewicz, Detection of 5-bromo-2-deoxyuridine incorporated into DNA by labeling strand breaks induced by photolysis (SBIP), Int. J. Oncol., Vol. 4, pp. 1157-1161, 1994.
11. R. C. Leif, M. C. Becker, A. J. Bromm Jr., L. M. Vallarino, S. A. Williams, and S. Yang, Increasing the Luminescence of Lanthanide(III) Macrocyclic Complexes by the Use of Polymers and Lanthanide Enhanced Luminescence, Optical Diagnostics of Living Cells IV, D. L. Farkas and R. C. Leif, Editors, SPIE BIOS Proceedings, Vol. 4260, pp. 184-197, 2001.
12. R. C. Leif, M. C. Becker, A. J. Bromm Jr., L. M. Vallarino, J. W. Williams, S. A. Williams, and S. Yang, Optimizing the Luminescence of Lanthanide(III) Macrocyclic Complexes for the Detection of anti-5-BrdU, Optical Diagnostics of Living Cells V, D. L. Farkas and R. C. Leif, Editors, SPIE Proceedings, Vol. 4622, pp. 250-261, 2002.
13. A. Kallioniemi, O-P. Kallioniemi, J. Piper, M. Tanner, T. Stokke, L. Chen, H. S. Smith, D. Pinkel, J. W. Gray, and F. M. Waldman, Detection and Mapping of Amplified DNA Sequences in Breast Cancer by Comparative Genomic Hybridization", Proc. Natl. Acad. Sci. USA. 91, pp. 2156-2160, 1994.
14. X. Xiao, M. E. Herring, J. Haushalter, S. Lee, K. S. Kalogerakis, and G. W. Paris, "Optical Property Measurements of A Novel Type of Upconverting Reporter, Genetically Engineered and Optical Probes for Biomedical Applications, A. P. Savitsky, D. J. Bornhop, R. Raghavachari, and S. I. Achilefu, Editors, SPIE Proceedings, Vol. 4967, pp. 172-178, 2003.
15. K. N. Raymond, S. Petoud, S. M. Cohen, J. Xu, US Patent 6,515,113, Phthalamide lanthanide complexes for use as luminescent markers, 2003.
16. R. C. Leif and L. M. Vallarino, PCT WO 01/27625 A1 (PCT/US00/27787), Conjugated Polymer Tag Complexes, 2001.