Synthesis of 1,2-disubstituted-3-alkylidenylpyrrolidines via a one-pot three-component reaction

Tetrahedron Letters

Volumn 45, Issue 46, 2004, Pages 8511-8514

  Huang, Wenwei ^a   O'Donnell, Mary Margaret ^a   Bi, Grace ^a   Liu, Jifeng ^a   Yu, Libing ^a   Baldino, Carmen M ^a   Bell, Andrew S ^b   Underwood, Toby J ^b  

^a ARQULE INC   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

3 Alkylidenylpyrrolidine; Multi component reaction; Pyrrolium salt; Retro aza Michael addition

Indexed keywords

ALDEHYDE; AMINE; CYCLOPROPANE DERIVATIVE; PYRROLIDINE DERIVATIVE;

ARTICLE; CHEMICAL REACTION; MICHAEL ADDITION; REACTION ANALYSIS; SYNTHESIS; TEMPERATURE SENSITIVITY;

EID: 5644273932     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.09.116     Document Type: Article

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14. The stereochemistry was determined by NOE analysis. (Chemical Presented)
15. 3, 75 MHz): δ 26.4, 30.8, 45.4, 52.4, 52.8, 57.8, 75.9, 123.0, 126.1, 127.3, 127.9, 128.1, 128.2, 129.1, 137.9, 142.6, 147.3