Solid phase synthesis of triazadibenzoazulenone

Synlett

Volumn , Issue 12, 2004, Pages 2242-2244

  Saha, Biswajit ^a   Srivastava, Gaurav Kumar ^a   Kundu, Bijoy ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Azulenone; Combinatorial chemistry; Cyclization; Heterocyclic; Solid phase synthesis

Indexed keywords

2 FLUORONITROBENZENE; 2 NITROBENZALDEHYDE; AMINO ACID; AZULENE DERIVATIVE; BENZALDEHYDE DERIVATIVE; HETEROCYCLIC COMPOUND; NITROBENZENE DERIVATIVE; TRIAZADIBENZOAZULENONE; UNCLASSIFIED DRUG;

ARTICLE; AUTOMATION; CHEMICAL REACTION; COMBINATORIAL CHEMISTRY; DRUG STRUCTURE; DRUG SYNTHESIS; REACTION ANALYSIS; SOLID;

EID: 5644221661     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-830888     Document Type: Article

References (17)

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15. 2O (4:1) to give the desired compounds I as acetate salts in >80% yields and >92% purities.
16. The quaternization of the nitrogen at N-12 in compound Ig was established by 1D NOE difference studies. Irradiation of -NH at δ = 10.69 ppm showed 15% enhancement of ortho doublet -CH at δ = 7.29 ppm. Further irradiation of the doublet at δ = 7.29 ppm gave 14% enhancement of the -NH at δ = 10.69 ppm. The above results established the close proximity of the -NH at δ = 10.69 ppm with the ortho doublet, which clearly suggests the quaternization of the nitrogen at N-12.
17. 3COOH: C, 66.01; H, 4.89; N, 13.58%. Found: C, 66.19; H, 4.85; N, 13.53%.