Delta-9-tetrahydrocannabinol (THC) serum concentrations and pharmacological effects in males after smoking a combination of tobacco and cannabis containing up to 69 mg THC

Psychopharmacology

Volumn 201, Issue 2, 2008, Pages 171-181

  Hunault, Claudine C ^a   Mensinga, Tjeert T ^a   De Vries, Irma ^a   Kelholt Dijkman, Hermien H ^b   Hoek, Jani ^b   Kruidenier, Maaike ^a   Leenders, Marianne E C ^a,c   Meulenbelt, Jan ^a,c,d  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b DeltaLab Laboratory   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Cannabis; Heart rate; High; Pharmacokinetics; THC

Indexed keywords

CANNABIS; DRONABINOL; PLACEBO;

ARTICLE; BLOOD LEVEL; BLOOD PRESSURE; CARDIOVASCULAR EFFECT; CIGARETTE SMOKING; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DROWSINESS; DRUG EFFECT; HEART RATE; HUMAN; LIQUID CHROMATOGRAPHY; MALE; METABOLITE; PRIORITY JOURNAL; SCORING SYSTEM; SERUM; TOBACCO;

ADOLESCENT; ADULT; AREA UNDER CURVE; BLOOD PRESSURE; CANNABIS; COGNITION; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; EMOTIONS; HALF-LIFE; HEART RATE; HUMANS; MALE; MARIJUANA SMOKING; PSYCHOMOTOR PERFORMANCE; RISK FACTORS; SERUM; SMOKING; TETRAHYDROCANNABINOL; TIME FACTORS; YOUNG ADULT;

EID: 56349167500     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-008-1260-2     Document Type: Article

References (28)

1. S Agurell M Halldin JE Lindgren A Ohlsson M Widman H Gillepsie L Hollister 1986 Pharmacokinetics and metabolism of delta 1-tetrahydrocannabinol and other cannabinoids with emphasis on man Pharmacol Rev 38 21 43
2. P Anzenbacher E Anzenbacherová 2001 Cytochromes P450 and metabolism of xenobiotics Cell Mol Life Sci 58 737 747
3. G Barnett CW Chiang M Perez-Reyes SM Owens 1982 Kinetic study of smoking marijuana J Pharmacokinet Biopharm 10 495 506
4. 1-tetrahydrocannabinol Drug Metab Depos 20 241 246
5. El Sohly MA (2004) Quarterly report potency monitoring project #85. National Center for Natural Products Research, University of Mississippi, Oxford, USA
6. EMCDDA (2007) Annual report from the EU drugs agency: the state of the drugs problem in Europe. Available at http://www.emcdda.europa.eu/html.cfm/ index419EN.html
7. RV Fant SJ Heishman EB Bunker WB Pickworth 1998 Acute and residual effects of marijuana in humans Pharmacol Biochem Behav 60 777 784
8. F Grothenhermen 2003 Pharmacokinetics and pharmacodynamics of cannabinoids Clin Pharmacokinet 42 327 360
9. RA Gustafson ET Moolchan A Barnes B Levine MA Huestis 2003 Validated method for the simultaneous determination of Delta 9-tetrahydrocannabinol (THC), 11-hydroxy-THC and 11-nor-9-carboxy-THC in human plasma using solid phase extraction and gas chromatography-mass spectrometry with positive chemical ionization J Chromatogr B Analyt Technol Biomed Life Sci 798 145 154
10. CL Hart W van Gorp M Haney RW Foltin MW Fischman 2001 Effects of acute smoked marijuana on complex cognitive performance Neuropsychopharmacology 25 757 765
11. MA Huestis AH Sampson BJ Holicky JE Henningfield EJ Cone 1992 Characterization of the absorption phase of marijuana smoking Clin Pharmacol Ther 52 31 41
12. MA Huestis JE Henningfield EJ Cone 1992 Blood cannabinoids. I. Absorption of THC and formation of 11-OH-THC and THCCOOH during and after smoking marijuana J Anal Toxicol 16 276 282
13. MA Huestis JE Henningfield EJ Cone 1992 Blood cannabinoids. II. Models for the prediction of time of marijuana exposure from plasma concentrations of delta 9-tetrahydrocannabinol (THC) and 11-nor-9-carboxy-delta 9-tetrahydrocannabinol (THCCOOH) J Anal Toxicol 16 283 290
14. P Kintz V Cirimele 1997 Testing human blood for cannabis by GC-MS Biomed Chromatogr 11 371 373
15. SD Lane DR Cherek OV Tcheremssine LM Lieving CJ Pietras 2005 Acute marijuana effects on human risk taking Neuropsychopharmacology 30 800 809
16. JE Lindgren A Ohlsson S Agurell L Hollister H Gillepsie 1981 Clinical effects and plasma levels of delta 9-tetrahydrocannabinol (delta 9-THC) in heavy and light users of cannabis Psychopharmacology 74 208 212
17. B Maralikova W Weinmann 2004 Simultaneous determination of Delta9-tetrahydrocannabinol, 11-hydroxy-Delta9-tetrahydrocannabinol and 11-nor-9-carboxy-Delta9-tetrahydrocannabinol in human plasma by high-performance liquid chromatography/tandem mass spectrometry J Mass Spectrom 39 526 531
18. MR Moeller G Doerr S Warth 1992 Simultaneous quantitation of delta-9-tetrahydrocannabinol (THC) and 11-nor-9-carboxy-delta-9- tetrahydrocannabinol (THC-COOH) in serum by GC/MS using deuterated internal standards and its application to a smoking study and forensic cases J Forensic Sci 37 969 983
19. Niesink RJM, Rigter S, Hoek J, Goldschmidt H (2007) THC-concentraties in wiet, nederwiet en hasj in Nederlandse coffeeshops (2006-2007). Trimbos Instituut, Utrecht, The Netherlands
20. A Ohlsson JE Lindgren A Wahlén S Agurell LE Hollister HK Gillepsie 1982 Single dose kinetics of deuterium labelled delta 1-tetrahydrocannabinol in heavy and light cannabis users Biomed Mass Spectrom 9 6 10
21. M Perez-Reyes S Di Guiseppi K Davis VH Schindler CE Cook 1982 Comparison of effects of marihuana cigarettes of three different potencies Clin Pharmacol Ther 31 617 624
22. JG Ramaekers G Kauert P van Ruitenbeek EL Theunissen E Schneider MR Moeller 2006 High-potency marijuana impairs executive function and inhibitory motor control Neuropsychopharmacology 31 2296 2303
23. P Tanswell J Koup 1993 TopFit: a PC-based pharmacokinetic-pharmacodynamic data analysis program Int J Clin Pharm Ther Toxicol 31 514 520
24. BF Thomas DR Compton BR Martin 1990 Characteristization of the lipophility of natural and synthetic analogs of delta 9-tetrahydrocannabinol and its relationship to pharmacological potency J Anal Toxicol 255 624 630
25. E Valjent JM Mitchell MJ Besson J Caboche R Maldonado 2002 Behavioural and biochemical evidence for interactions between Delta 9-tetrahydrocannabinol and nicotine Br J Pharmacol 135 564 578
26. K Watanabe S Yamaori T Funahashi T Kimura I Yamamoto 2007 Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes Life Sci 80 1415 1419
27. 1- tetracannabinol to blood cells and plasma proteins in man J Pharm Pharmacol 26 914 916
28. World Drug Report (2006) Volume 1 (analysis). United Nations Office on Drugs and Crime, United Nations Publication Sales No. E.06.XI.10