PKU-β/TLK1 regulates myosin II activities, and is required for accurate equaled chromosome segregation

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 657, Issue 1, 2008, Pages 63-67

  Hashimoto, Mitsumasa ^a   Matsui, Tadashi ^a   Iwabuchi, Kuniyoshi ^a   Date, Takayasu ^a  

^a KANAZAWA MEDICAL UNIVERSITY   (Japan)

Author keywords

Chromosome segregation; Myosin II; PKU TLK1

Indexed keywords

MYOSIN II; PROTEIN KINASE UBIQUITOUS BETA; PROTEIN SERINE THREONINE KINASE; TOUSLED LIKE KINASE 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHROMOSOME SEGREGATION; IMMUNOBLOTTING; MITOSIS; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; WILD TYPE;

ANEUPLOIDY; CELL CYCLE; CHROMOSOME SEGREGATION; GENE EXPRESSION REGULATION; HUMANS; MYOSIN LIGHT CHAINS; MYOSIN TYPE II; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES;

EID: 56349134901     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2008.09.001     Document Type: Article

References (14)

1. Yamakawa A., Kameoka Y., Hashimoto K., Yoshitake Y., Nishikawa K., Tanihara K., and Date K.T. cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal. Gene 202 (1997) 193-201
2. Roe J.L., Rivin C.J., Sessions R.A., Feldmann K.A., and Zambryski P.C. The tousled gene in A. thaliana encodes a protein kinase homolog that is required for leaf and flower development. Cell 75 (1993) 939-950
3. Shalom S., and Don J. Tlk, a novel evolutionarily conserved murine serine threonine kinase, encodes multiple testis transcripts. Mol. Reprod. Dev. 52 (1999) 392-405
4. Sillje H.H., Takahashi K., Tanaka K., Van Houwe G., and Nigg E.A. Mammalian homologues of the plant tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication. EMBO J. 18 (1999) 5691-5702
5. Sillje H.H., and Nigg E.A. Identification of human Asf1 chromatin assembly factors as substrates of tousled-like kinases. Curr Biol. 11 (2001) 1068-1073
6. Komatsu S., Yano T., Shibata M., Tuft R.A., and Ikebe M. Effects of the regulatory light chain phosphorylation of myosin II on mitosis and cytokinesis of mammalian cells. J. Biol. Chem. 275 (2000) 34512-34520
7. Trybus K.M. Filamentous smooth muscle myosin is regulated by phosphorylation. J. Cell Biol. 109 (1989) 2887-2894
8. Ikebe M., Koretz J., and Hartshorne D.J. Effects of phosphorylation of light chain residues threonine 18 and serine 19 on the properties and conformation of smooth muscle myosin. J. Biol. Chem. 263 (1988) 6432-6437
9. Iwasaki T., Murata-Hori M., Ishitobi S., and Hosoya H. Diphosphorylated MRLC is required for organization of stress fibers in interphase cells and the contractile ring in dividing cells. Cell Struct. Funct. 26 (2001) 677-683
10. Rosenblatt C., Gramer L.P., Baum B., and McGee K.M. Myosin II-dependent cortical movement is required for centrosome separation and positioning during mitotic spindle assembly. Cell 117 (2004) 361-372
11. Fumoto K., Uchimura T., Iwasaki T., Ueda K., and Hosoya H. Phosphorylation of myosin II regulatory light chain is necessary for migration of HeLa cells but not for localization of myosin II at the leading edge. Biochem. J. 370 (2003) 551-556
12. Li Y., DeFatta R., Anthony C., Sunavala G., and De Benedetti A. A translationally regulated tousled kinase phosphorylates histone H3 and confers radioresistance when overexpressed. Oncogene 20 (2001) 726-738
13. Sunavala-Dossabhoy G., Li Y., Williams B., and De Benedetti A. A dominant negative mutant of TLK1 causes chromosome missegregation and aneuploidy in normal breast epithelial cells. BMC Cell Biol. 4 (2003) 16
14. Han Z., Riefler G.M., Saam J.R., Mango S.E., and Schumacher J.M. The C. elegans tousled-like kinase contributes to chromosome segregation as a substrate and regulator of the Aurora B kinase. Curr. Biol. 15 (2005) 894-904