Isolation and characterization of human anti-VEGF165 monoclonal antibody with anti-tumor efficacy from transgenic mice expressing human immunoglobulin loci

Cancer Letters

Volumn 273, Issue 1, 2009, Pages 28-34

  Liu, Yu ^a   Yun, Dong jie ^a   Chen, Jian quan ^b   Zhao, Jian yang ^b   Liu, Si guo ^b   Cheng, Guo xiang ^b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b Shanghai Genon Bioengineering CO   (China)

Author keywords

Anti tumor; Five feature mice; Fully human mAb; VEGF165

Indexed keywords

IMMUNOGLOBULIN M; MONOCLONAL ANTIBODY; VASCULOTROPIN 165; VASCULOTROPIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; COLORECTAL CANCER; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG EFFICACY; DRUG SAFETY; HALF LIFE TIME; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN ISOLATION; PROTEIN SECRETION; RAT; TRANSGENIC MOUSE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; HUMANS; IMMUNOGLOBULIN M; MALE; MICE; MICE, NUDE; MICE, TRANSGENIC; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

MUS; MUS MUSCULUS;

EID: 56349108008     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2008.07.022     Document Type: Article

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