Histamine bronchoprovocation does not affect bronchoalveolar lavage fluid cytology, gene expression and protein concentrations of IL-4, IL-8 and IFN-γ

Veterinary Immunology and Immunopathology

Volumn 126, Issue 3-4, 2008, Pages 230-235

  Perkins, G A ^a   Viel, L ^b   Wagner, B ^a   Hoffman, A ^c   Erb, H N ^a   Ainsworth, D M ^a  

^a Department of Obstetrics Gynecology   (United States)

^b UNIVERSITY OF GUELPH   (Canada)

^c TUFTS UNIVERSITY   (United States)

Author keywords

BAL; Cytokines; ELISA; Histamine bronchoprovocation; Real time RT PCR

Indexed keywords

BETA ACTIN; GAMMA INTERFERON; HISTAMINE; INTERLEUKIN 4; INTERLEUKIN 8; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOLOGY; ENDOSCOPY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HISTAMINE TEST; HORSE; LEUKOCYTE COUNT; LUNG LAVAGE; LUNG LOBE; NONHUMAN; PROVOCATION TEST; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY TRACT DISEASE;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; HISTAMINE; HORSE DISEASES; HORSES; INTERFERON-GAMMA; INTERLEUKIN-4; INTERLEUKIN-8; RESPIRATORY HYPERSENSITIVITY;

EQUIDAE;

EID: 56349089917     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetimm.2008.07.006     Document Type: Article

References (31)

1. Ainsworth D.M., Grünig G., Matychak M.B., et al. Recurrent airway obstruction (RAO) in horses is characterized by IFN-γ and IL-8 production in bronchoalveolar lavage cells. Vet. Immunol. Immunopathol. 96 (2003) 83-91
2. Ainsworth D.M., Wagner B., Franchini M., et al. Time-dependent alterations in IL-8 gene expression in the bronchial epithelium of horses with recurrent airway obstruction. Am. J. Vet. Res. 67 (2006) 669-677
3. Bland J.M., and Altman D.G. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1 (1986) 307-310
4. Beer D.J., and Rocklin R.E. Histamine modulation of lymphocyte biology: membrane receptors, signal transduction, and function. Crit. Rev. Immunol. 7 (1987) 55-91
5. Cameron W., Doyle K., and Rocklin R.E. Histamine type I (H1) receptor radioligand binding studies on normal T cell subsets, B cells, and monocytes. J. Immunol. 136 (1986) 2116-2120
6. Cockcroft D.W. Bronchoprovocation methods: direct challenges. Clin. Rev. Allergy Immunol. 24 (2003) 19-26
7. Couëtil L.L., Hoffman A.M., Hodgson J., et al. Inflammatory airway disease of horses. J. Vet. Intern. Med. 21 (2007) 256-361
8. DeLuca L., Erb H.N., Young J.C., Perkins G.A., and Ainsworth D.M. The effect of adding oral dexamethasone to feed alterations on the airway cell inflammatory gene expression in stabled horses affected with recurrent airway obstruction. J. Vet. Intern. Med. 22 (2008) 427-435
9. Dohlsten M., Sjörgren H.O., and Carlsson R. Histamine inhibits interferon-gamma production via suppression of interleukin 2 synthesis. Cell Immunol. 101 (1986) 493-501
10. Franchini M., Gill U., von Fellenberg R., et al. Interleukin-8 concentration and neutrophil chemoatactic activity in bronchoalveolar lavage fluid of horses with chronic obstructive pulmonary disease following exposure to hay. Am. J. Vet. Res. 61 (2000) 1369-1374
11. Hare J.E., and Viel L. Pulmonary eosinophilia associated with increased airway responsiveness in young racing horses. J. Vet. Intern. Med. 12 (1998) 163-170
12. Hare J.E., Viel L., O'Byrne P.M., and Conlon P.D. Effect of sodium cromoglycate on light racehorses with elevated metachromatic cell numbers on bronchoalveolar lavage and reduced exercise tolerance. J. Vet. Pharmacol. Therap. 17 (1994) 237-244
13. Holden N.S., Gong W., King E.M., et al. Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. Br. J. Pharm. 152 (2007) 891-902
14. Hoffman A.M., Mazan M.R., and Ellenberg S. Association between bronchoalveolar lavage cytologic features and airway reactivity in horses with a history of exercise intolerance. Am. J. Vet. Res. 59 (1998) 176-181
15. Kirschvink N., Fiévez L., Dogné S., et al. Comparison of inulin with urea as dilutional markers of bronchoalveolar lavage in healthy and heaves-affected horses. Vet. Res. 32 (2001) 145-154
16. Kitawaki T., Kadowaki N., Sugimoto N., et al. IgE-activated mast cells in combination with pro-inflammatory factors induce Th2-promoting dendritic cells. Int. Immunol. 18 (2006) 1789-1799
17. Klein H.J., and Deegen E. Histamine inhalation provocation test: method to identify nonspecific airway reactivity in equids. Am. J. Vet. Res. 47 (1986) 1796-1800
18. Krouwels F.H., Hol B.E.A., Lutter R., et al. Histamine affects interleukin-4, interleukin-5 and interferon-γ production by human T cell cones from the airways and blood. Am. J. Respir. Cell. Mol. Biol. 18 (1998) 721-730
19. Leguillette R., and Lavoie J.P. Effects of the bronchoalveolar lavage procedure on lung function in horses with clinical exacerbation of recurrent airway obstruction. Am. J. Vet. Res. 67 (2006) 1929-1933
20. +2-dependent protein kinase C, Raf/MEK/ERK and IKK/IκB/NF-κB signal cascades. Biochem. Pharm. 69 (2005) 433-449
21. Mazan M.R., Hoffman A.M., and Manjerovic N. Comparison of forced oscillation with the conventional method for histamine bronchoprovocation testing in horses. Am. J. Vet. Res. 60 (1999) 174-180
22. Mazzoni A., Young H.A., Spitzer J.H., et al. Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization. J. Clin. Invest. 108 (2001) 1865-1873
23. Mazzoni A., Siraganian R., Leifer C.A., and Segal D.M. Dendritic cell modulation by mast cell controls the Th1/Th2 balance in responding T cells. J. Immunol. 177 (2006) 3577-3581
24. Moore B.R., Krakowa S., Robertson J.T., and Cummins J.M. Cytologic evaluation of bronchoalveolar lavage fluid obtained from Standardbred racehorses with inflammatory airway disease. Am. J. Vet. Res. 56 (1995) 562-567
25. Mosmann T.R., and Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today 17 (1996) 138-146
26. Packard K.A., and Khan M.M. Effects of histamine on Th1/Th2 cytokine balance. Int. Immunopharmacol. 3 (2003) 909-920
27. Prendiville A., Green S., and Silverman M. Airway responsiveness in wheezy infants: evidence for functional beta receptors. Thorax 42 (1987) 100-104
28. Schoonjans F., Zalata A., Depuydt C.E., and Comhaire F.H. MedCalc: a new computer program for medical statistics. Comput. Methods Programs Biomed. 48 (1995) 257-262
29. Togias A. H1-receptors: localization and role in airway physiology and in immune functions. J. Allergy Clin. Immunol. 112 (2003) S60-S68
30. Wagner B., Radbruch A., Rohwer J., and Leibold W. Monoclonal anti-equine IgE antibodies with specificity for different epitopes on the immunoglobulin heavy chain of native IgE. Vet. Immunol. Immunopathol. 92 (2003) 45-60
31. Wagner B., Robeson J., McCracken M., et al. Horse cytokine/IgG fusion proteins-mammalian expression of biologically active cytokines and a system to verify antibody specificity to equine cytokines. Vet. Immunol. Immunopathol. 105 (2005) 1-14