Effects of Transcranial Ultrasound and Intravenous Microbubbles on Blood Brain Barrier Permeability in a Large Animal Model

Ultrasound in Medicine and Biology

Volumn 34, Issue 12, 2008, Pages 2028-2034

  Xie, Feng ^a   Boska, Michael D ^a   Lof, John ^a   Uberti, Mariano G ^a   Tsutsui, Jeane M ^a   Porter, Thomas R ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Blood brain barrier; Microbubbles; Ultrasound

Indexed keywords

ACOUSTIC WAVES; BLOOD; BONE; CAPILLARITY; DRUG DELIVERY; ENDOTHELIAL CELLS; GADOLINIUM; GENE TRANSFER; INDUCTIVELY COUPLED PLASMA; LIQUIDS; MAGNETIC RESONANCE IMAGING; OXYGEN; RESONANCE; ULTRASONIC IMAGING; ULTRASONIC TRANSMISSION; ULTRASONICS;

AND SCATTERINGS; ANIMAL MODELS; ARTERIAL PRESSURES; BLOOD BRAIN BARRIER; BLOOD BRAIN BARRIERS; CLINICAL APPLICATIONS; DUTY CYCLES; EVANS BLUES; GENE DELIVERIES; INSONATION; INTEGRAL COMPONENTS; INTRAVENOUS INJECTIONS; MICROBUBBLE; MICROBUBBLE INJECTIONS; MICROBUBBLES; NEGATIVE PRESSURES; NONINVASIVE METHODS; OXYGEN SATURATIONS; PERFLUOROCARBON; SMALL ANIMALS; SPECTROPHOTOMETRIC ANALYSIS; TEMPORAL BONES; TRANSCRANIAL ULTRASOUNDS; ULTRASOUND;

ULTRASONIC APPLICATIONS;

ALBUMIN; EVANS BLUE; FLUOROCARBON; GADOLINIUM; LIPID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTRAST ENHANCEMENT; CONTROLLED STUDY; EXPERIMENTAL MODEL; EXPERIMENTAL PIG; EXTRAVASATION; HEART RATE; MEAN ARTERIAL PRESSURE; MEMBRANE PERMEABILITY; MICROBUBBLE; NON INVASIVE PROCEDURE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OXYGEN SATURATION; PRIORITY JOURNAL; SAFETY; SPECTROPHOTOMETRY; TEMPORAL BONE; ULTRASOUND;

ANIMALS; BLOOD-BRAIN BARRIER; CAPILLARY PERMEABILITY; COLORING AGENTS; DRUG DELIVERY SYSTEMS; EVANS BLUE; FEASIBILITY STUDIES; GADOLINIUM; MAGNETIC RESONANCE IMAGING; MICROBUBBLES; MODELS, ANIMAL; SONICATION; SPECTROPHOTOMETRY; SUS SCROFA;

EID: 56249135555     PISSN: 03015629     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ultrasmedbio.2008.05.004     Document Type: Article

References (16)

1. Abbott N.J., Ronnback L., and Hansson E. Astrocyte-endothelial interactions at the blood brain barrier. Nat Rev Neurosci 7 1 (2006) 41-53
2. Holland C.K., and Apfel R.E. Thresholds for transient cavitation produced by pulsed ultrasound in a controlled nuclei environment. J Acoust Soc Am 88 (1990) 2059-2069
3. Hynynen K., McDannold N., Vykhodtseva N., and Jolesz F.A. Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits. Radiology 220 (2001) 640-646
4. Kinoshita M., McDannold N., Jolesz F.A., and Hynynen K. Targeted delivery of antibodies through the blood-brain barrier by MRI-guided focused ultrasound. Biochem Biophys Res Commun 340 (2006) 1085-1090
5. Lange S., Delbro D.S., and Jennische E. Evans blue permeation of intestinal mucosa in the rat. Scand J Gastroenterol 29 1 (1994) 38-46
6. Levy D., Kost J., Meshulam Y., and Langer R. Effect of ultrasound on transdermal drug delivery to rats and guinea pigs. J Clin Invest 83 (1989) 2074-2078
7. McDannold N., Vykhodtseva N., and Hynynen K. Targeted disruption of the blood-brain barrier with focused ultrasound: Association with cavitational activity. Phys Med Biol 51 (2006) 793-807
8. McDannold N., Vykhodtseva N., and Hynynen K. Use of Ultrasound pulses combined with Definity for targeted blood-brain barrier disruption: A feasibility study. Ultrasound Med Biol 33 4 (2007) 584-590
9. Park D.M., Kulkarni P., Arora V., Antich P., Bonte F., Wu A., Mallikarjuana N.N., Manohar S., Liang H.-F., Kulkarni A.R., Sung H.-W., Sairam M., and Aminabhavi T.M. Targeted nanoparticles for drug delivery through the blood-brain barrier for Alzheimer's disease. J Control Release 108 (2005) 193-214
10. Raymond S.B., Skoch J., Hynynen K., and Bacskai B.J. Multiphoton imaging of ultrasound/Optison mediated cerebrovascular effects in vivo. J Cerebr Blood Flow Meta 27 (2007) 393-403
11. Rubenstein J.L., Combs D., Rosenberg J., et al. Rituximab therapy for CNS lymphomas: Targeting the leptomeningeal compartment. Blood 101 (2003) 466-468
12. Sheikov N., McDannold N., Vykhodtseva N., Jolesz F., and Hynynen K. Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles. Ultrasound Med Biol 30 (2004) 979-989
13. Soussain C., Hoang-Xuan K., and Doolittle N.D. New treatment approaches in primary central nervous system lymphoma. Hematol Oncol Clin North Am 19 (2005) 719-728
14. Treat L., McDannold N., Vykhodtseva N., Zhang Y., Tam K., and Hynynen K. Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound. Int J Cancer 121 (2007) 901-907
15. Wolka A.M., Huber J.D., and Davis T.P. Pain and the blood brain barrier: obstacles to drug delivery. Adv Drug Deliv Rev 55 (2003) 987-1006
16. Vykhodtseva N., McDannold N., and Hynynen K. Induction of apoptosis in vivo in the rabbit brain with focused ultrasound and Optison. Ultrasound Med Biol 32 12 (2006) 1923-1929