A comparative study of the therapeutic effects of the Zataria multiflora vaginal cream and metronidazole vaginal gel on bacterial vaginosis

Phytomedicine

Volumn 15, Issue 12, 2008, Pages 1025-1031

  Simbar, M ^a   Azarbad, Z ^b   Mojab, F ^a   Alavi Majd, H ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b KASHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Bacterial vaginosis; Metronidazole; Zataria multiflora

Indexed keywords

CARVACROL; LOUCOREX; METRONIDAZOLE; THYMOL; UNCLASSIFIED DRUG;

ADULT; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREAM; EVENING DOSAGE; FEMALE; FISHER EXACT TEST; GEL; GRAM STAINING; HERBAL MEDICINE; HUMAN; MAJOR CLINICAL STUDY; MEDICINAL PLANT; METALLIC TASTE; NAUSEA; PRESCRIPTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TASTE DISORDER; THERAPY EFFECT; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE; VAGINAL BURNING SENSATION; VAGINAL DRYNESS; VAGINITIS; VERTIGO; ZATARIA MULTIFLORA;

ADMINISTRATION, INTRAVAGINAL; ADULT; ANTI-BACTERIAL AGENTS; FEMALE; HUMANS; LAMIACEAE; METRONIDAZOLE; PHYTOTHERAPY; PLANT PREPARATIONS; VAGINAL CREAMS, FOAMS, AND JELLIES; VAGINOSIS, BACTERIAL;

BACTERIA (MICROORGANISMS); ZATARIA MULTIFLORA;

EID: 56249124905     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2008.08.004     Document Type: Article

References (34)

1. Agnihotri S., and Vaidya A.D. A novel approach to study antibacterial properties of volatile components of selected Indian medicinal herbs. Indian J. Exp. Biol. 34 (1996) 712-715
2. Akhound-Zadeh Basti A., Misaghi A., and Gheibi S. Effects of essential oil of Zataria multiflora on Bacillus cerus growth in liquid extract of brain and. Herbal Med. 16 (2005) 48-55
3. Amanlou M., Beitollahi J.M., Abdollahzadeh S., and Tohidast-Ekrad Z. Miconazole gel compared with Zataria multiflora Boiss. gel in the treatment of denture stomatitis. Phytother. Res. 20 (2006) 966-969
4. Austin M.N., Beigi R.H., Meyn L.A., and Hillier S.L. Microbiologic response to treatment of bacterial vaginosis with topical clindamycin or metronidazole. Clin. Microbiol. 43 (2005) 4492-4497
5. Azadbakht M., Ziai H., Abdollahi F., and Shabankhani B. Effect of essential oils of Artemisia aucheri Boiss., Zataria multiflora Boiss. and Myrtus communis L. on Trichomonas vaginalis. Herbal Med. 2 (2003) 35-40
6. Baloglu A. A randomized controlled trial of a new ovule formulation of orindazole for the treatment of bacterial vaginosis. J. Clin. Pharm. Ther. 28 (2003) 131-136
7. Beigi R.H., Austin M.N., Meyn L.A., Krohn M.A., and Hillier S.L. Antimicrobial resistance associated with the treatment of bacterial vaginosis. Am. J. Obstet. Gynecol. 191 (2004) 1124-1129
8. Cauci S., Driussi S., De Santo D., Penacchioni P., Iannicelli T., Lanzafame P., De Seta F., Quadrifoglio F., de Aloysio D., and Guaschino S. Prevalence of bacterial vaginosis and vaginal flora changes in peri- and postmenopausal women. J. Clin. Microbiol. 40 (2002) 2147-2152
9. Cowan M.M. Plant products as antimicrobial agents. Clin. Microbiol. Rev. 12 (1999) 564-582
10. DiPasqua R., Hoskins N., Betts G., and Mauriello G. Changes in membrane fatty acids composition of microbial cells induced by addiction of thymol, carvacrol, limonene, cinnamaldehyde and eugenol in the growing media. J. Agric. Food Chem. 54 (2006) 2745-2749
11. Fan M., and Chen J. Studies on antimicrobial activity of extracts from thyme. Wei Sheng Wu Xue Bao 41 (2001) 499-504
12. Fouladi, A., 2003. A comparison between Zataria multiflora essence creams with cloterimazole on treatment of candidia vaginaitis. Master Thesis, Faculty of Nursing and Midwifery, Ahvaz Medical Sciences University, Iran.
13. Gutman R.E., Peipert J.F., and Blurne J. Evaluation of clinical methods for diagnosing bacterial vaginosis. Obstet. Gynecol. 105 (2005) 551-556
14. Islami A., Ansari A., Kashanian M., Bekhradi R., Akbari M., Akbari H., and Darabi M. Zataria multiflora vaginal cream compared with clotrimazole vaginal cream in the treatment of candida vaginitis. Iran. J. Pharm. Res. Suppl. 2 (2004) 36-37
15. Jafari Sh., Amanlou M., Borhan-Mojabi K., and Farsam H. Comparative study of Zataria multiflora and Anthemis nobelis extracts with Myrthus communis preparation in the treatment of recurrent aphthous stomatitis. Daru 11 (2003) 23-27
16. Kelemba D., and Kunicka A. Antibacterial and antifungal properties of essential oils. Curr. Med. Chem. 10 (2003) 813-829
17. Kessel K., Assefi N., Marrazzo J., and Eckert L. Common complementary and alternative therapies for yeast vaginitis and bacterial vaginosis: a systemic review. Obstet. Gynecol. Surv. 58 (2003) 351-358
18. Klepser T.B., and Klepser M.E. Unsafe and potentially safe herbal therapies. Am. J. Health Syst. Pharm. 56 (1999) 125-138
19. López P., Sanchez C., Batlle R., and Nerín C. Vapor-phase activities of cinnamon, thyme and oregano essential oils and key constituents against foodborne microorganisms. J. Agric. Food Chem. 55 (2007) 4348-4356
20. Mansouri P., Hadjiakhondi A., Ghavami R., and Shafiee A. Clinical evaluation of Zataria multiflora essential oil mouthwash in the management of recurrent afthous stomatitis. Daru 10 (2002) 74-77
21. McGregor J.A., and French J.I. Bacterial vaginosis in pregnancy. Obstet. Gynecol. Surv. 55 (2000) S1-S19
22. Medline Plus, Clindamicine, 2007. American Society of Health-System Pharmacists, Inc, 〈http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682399.html#side-effects〉.
23. Medline Plus, Herbal Medicine, 2008. National Center for Complementary and Alternative Medicine, 〈http://www.nlm.nih.gov/medlineplus/herbalmedicine.html〉.
24. Ozcan M.M., Saǧdiç O., and Ozkan G. Inhibitory effects of spice essential oils on the growth of Bacillus species. J. Med. Food 9 (2006) 418-421
25. Pheifer T.A., Forsyth P.S., and Durfee M.A. Nonspecific vaginitis: role of Haemophilus vaginalis and treatment with methronidazole. New Engl. J. Med. 298 (1978) 1429-1434
26. Saleem, M., 2000. Chemical and biological screening of some relatives of lamiaceae (labiatae) family and marine alga codium iyengarii. Thesis submitted for the fulfillment of the degree doctor of Philosophy. International Centre for Chemical Sciences HEJ Research Institute of Chemistry, University of Karachi, Karachi. 〈http://eprints.hec.gov.pk/873/1/641.htm〉.
27. Saleem M., Nazli R., Afza N., Sami A., and Ali M.S. Biological significance of essential oil of Zataria multiflora Boiss. Nat. Prod. Res. 18 (2004) 493-497
28. Shafiee A., and Javidnia K. Composition of essential oil of Zataria multiflora. Planta Med. 63 (1997) 371-372
29. Sweet R.L. Gynecologic conditions and bacterial vaginosis: implications for the non-pregnant patient. Infect. Dis. Obstet. Gynecol. 8 (2000) 184-190
30. Wain A.M. Metronidazole vaginal gel 0.75% (Metrogel-vaginal): a brief review. Infect. Dis. Obstet. Gynecol. 6 (1998) 3-7
31. Weir E. Public health: bacterial vaginosis: more questions than answers. CMAJ 171 (2004) 448
32. World Health Organization. WHO Monographs on Selected Medicinal Plants vol. 1 (1999), WHO, Geneva
33. World Health Organization. WHO Traditional Medicine Strategy 2002-2005 (2002), WHO, Geneva
34. Yen S., Shafer M.A., Moncada J., Campbell C.J., Flinn S.D., and Boyer C.B. Bacterial vaginosis in sexually experienced and nonsexually experienced young women entering the military. Obstet. Gynecol. 102 (2003) 927-933