The p53 pathway and radio- and chemosensitivity of SCCHN

Oral Oncology

Volumn 44, Issue 12, 2008, Pages 1091-1092

  McCaul, James A ^a  

^a ST LUKE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

APOPTOSIS; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CELL CYCLE ARREST; CELL DIVISION; CHEMOSENSITIVITY; EDITORIAL; GENE MUTATION; HEAD AND NECK CARCINOMA; HEREDITY; PRIORITY JOURNAL; RADIOSENSITIVITY; SQUAMOUS CELL CARCINOMA; TELOMERE;

CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; HEAD AND NECK NEOPLASMS; HUMANS; RADIATION TOLERANCE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 56249124577     PISSN: 13688375     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.oraloncology.2008.02.014     Document Type: Editorial

References (8)

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2. McCaul J.A., Gordon K.E., Minty F., Fleming J., and Parkinson E.K. Telomere dysfunction is related to the intrinsic radio-resistance of human oral cancer cells. Oral Oncol 44 3 (2008) 261-269
3. Strano S., Fontemaggi G., Costanzo A., Rizzo M.G., Monti O., Baccarini A., et al. Physical interaction with human tumor-derived p53 mutants inhibits p63 activities. J Biol Chem 277 21 (2002) 18817-18826
4. Kropveld A., Rozemuller E.H., Leppers F.G., Scheidel K.C., de Weger R.A., Koole R., et al. Sequencing analysis of RNA and DNA of exons 1 through 11 shows p53 gene alterations to be present in almost 100% of head and neck squamous cell cancers. Lab Invest 79 3 (1999) 347-353
5. Nemunaitis J., Khuri F., Ganly I., Arseneau J., Posner M., Vokes E., et al. Phase II trial of intratumoral administration of ONYX-015, a replication-selective adenovirus, in patients with refractory head and neck cancer. J Clin Oncol 19 2 (2001) 289-298
6. Cuddihy A.R., and Bristow R.G. The p53 protein family and radiation sensitivity: Yes or no?. Cancer Metast Rev 23 3-4 (2004) 237-257
7. Lothaire P., de A.E., Dequanter D., Lalami Y., Sotiriou C., Andry G., et al. Molecular markers of head and neck squamous cell carcinoma: promising signs in need of prospective evaluation. Head Neck 28 3 (2006) 256-269
8. Hoffman T.K., Sonkoly E., Hauser U., van Lierop A., Whiteside T.L., Klussmann J.P., et al. Alterations in the p53 pathway and their association with radio- and chemosensitivity in head and neck squamous cell carcinoma. Oral Oncol 44 12 (2008) 1100-1109