-
1
-
-
4043181214
-
Cancer genes and the pathways they control
-
Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med 2004; 10: 789-799.
-
(2004)
Nat Med
, vol.10
, pp. 789-799
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
2
-
-
6044229354
-
Concepts of human leukemic development
-
Warner JK, Wang JC, Hope KJ, Jin L, Dick JE. Concepts of human leukemic development. Oncogene 2004; 23: 7164-7177.
-
(2004)
Oncogene
, vol.23
, pp. 7164-7177
-
-
Warner, J.K.1
Wang, J.C.2
Hope, K.J.3
Jin, L.4
Dick, J.E.5
-
3
-
-
0141634051
-
Origins of chromosome translocations in childhood leukaemia
-
Greaves MF, Wiemels J. Origins of chromosome translocations in childhood leukaemia. Nat Rev Cancer 2003; 3: 639-649.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 639-649
-
-
Greaves, M.F.1
Wiemels, J.2
-
4
-
-
0017362792
-
15/17 translocation, a consistent chromosomal change in acute promyelocytic leukaemia
-
Rowley JD, Golomb HM, Dougherty C. 15/17 translocation, a consistent chromosomal change in acute promyelocytic leukaemia. Lancet 1977; 1: 549-550.
-
(1977)
Lancet
, vol.1
, pp. 549-550
-
-
Rowley, J.D.1
Golomb, H.M.2
Dougherty, C.3
-
5
-
-
0017758445
-
Further evidence for a non-random chromosomal abnormality in acute promyelocytic leukemia
-
Rowley JD, Golomb HM, Vardiman J, Fukuhara S, Dougherty C, Potter D. Further evidence for a non-random chromosomal abnormality in acute promyelocytic leukemia. Int J Cancer 1977; 20: 869-872.
-
(1977)
Int J Cancer
, vol.20
, pp. 869-872
-
-
Rowley, J.D.1
Golomb, H.M.2
Vardiman, J.3
Fukuhara, S.4
Dougherty, C.5
Potter, D.6
-
6
-
-
0027373893
-
Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia
-
Liu P, Tarle SA, Hajra A, Claxton DF, Marlton P, Freedman M et al. Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia. Science 1993; 261: 1041-1044.
-
(1993)
Science
, vol.261
, pp. 1041-1044
-
-
Liu, P.1
Tarle, S.A.2
Hajra, A.3
Claxton, D.F.4
Marlton, P.5
Freedman, M.6
-
7
-
-
18544375333
-
MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia
-
Armstrong SA, Staunton JE, Silverman LB, Pieters R, den Boer ML, Minden MD et al. MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat Genet 2002; 30: 41-47.
-
(2002)
Nat Genet
, vol.30
, pp. 41-47
-
-
Armstrong, S.A.1
Staunton, J.E.2
Silverman, L.B.3
Pieters, R.4
den Boer, M.L.5
Minden, M.D.6
-
8
-
-
33947581390
-
The impact of translocations and gene fusions on cancer causation
-
Mitelman F, Johansson B, Mertens F. The impact of translocations and gene fusions on cancer causation. Nat Rev Cancer 2007; 7: 233-245.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 233-245
-
-
Mitelman, F.1
Johansson, B.2
Mertens, F.3
-
9
-
-
33846876123
-
Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): Biologic and clinical features
-
Falini B, Nicoletti I, Martelli MF, Mecucci C. Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): Biologic and clinical features. Blood 2007; 109: 874-885.
-
(2007)
Blood
, vol.109
, pp. 874-885
-
-
Falini, B.1
Nicoletti, I.2
Martelli, M.F.3
Mecucci, C.4
-
10
-
-
34147224008
-
Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia
-
Mullighan CG, Goorha S, Radtke I, Miller CB, Coustan-Smith E, Dalton JD et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 2007; 446: 758-764.
-
(2007)
Nature
, vol.446
, pp. 758-764
-
-
Mullighan, C.G.1
Goorha, S.2
Radtke, I.3
Miller, C.B.4
Coustan-Smith, E.5
Dalton, J.D.6
-
11
-
-
24944460366
-
FLT3 and acute myelogenous leukemia: Biology, clinical significance and therapeutic applications
-
Advani AS. FLT3 and acute myelogenous leukemia: Biology, clinical significance and therapeutic applications. Curr Pharm Des 2005; 11: 3449-3457.
-
(2005)
Curr Pharm Des
, vol.11
, pp. 3449-3457
-
-
Advani, A.S.1
-
12
-
-
9144244169
-
FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy
-
Taketani T, Taki T, Sugita K, Furuichi Y, Ishii E, Hanada R et al. FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy. Blood 2004; 103: 1085-1088.
-
(2004)
Blood
, vol.103
, pp. 1085-1088
-
-
Taketani, T.1
Taki, T.2
Sugita, K.3
Furuichi, Y.4
Ishii, E.5
Hanada, R.6
-
13
-
-
0025729836
-
Defining the molecular mechanisms of human cell immortalization
-
Shay JW, Wright WE, Werbin H. Defining the molecular mechanisms of human cell immortalization. Biochim Biophys Acta 1991; 1072: 1-7.
-
(1991)
Biochim Biophys Acta
, vol.1072
, pp. 1-7
-
-
Shay, J.W.1
Wright, W.E.2
Werbin, H.3
-
14
-
-
50549195640
-
Cytology of Burkitt's tumour (African lymphoma)
-
Pulvertaft JV. Cytology of Burkitt's tumour (African lymphoma). Lancet 1964; 1: 238-240.
-
(1964)
Lancet
, vol.1
, pp. 238-240
-
-
Pulvertaft, J.V.1
-
15
-
-
0033739985
-
Continuous hematopoietic cell lines as model systems for leukemia-lymphoma research
-
Drexler HG, Matsuo AY, MacLeod RA. Continuous hematopoietic cell lines as model systems for leukemia-lymphoma research. Leuk Res 2000; 24: 881-911.
-
(2000)
Leuk Res
, vol.24
, pp. 881-911
-
-
Drexler, H.G.1
Matsuo, A.Y.2
MacLeod, R.A.3
-
16
-
-
0019142091
-
Human myeloid leukemia cell lines: A review
-
Koeffler HP, Golde DW. Human myeloid leukemia cell lines: A review. Blood 1980; 56: 344-350.
-
(1980)
Blood
, vol.56
, pp. 344-350
-
-
Koeffler, H.P.1
Golde, D.W.2
-
17
-
-
0028911281
-
Recurrent chromosomal translocations and fusion genes in leukemia-lymphoma cell lines
-
Drexler HG, MacLeod RA, Borkhardt A, Janssen JW. Recurrent chromosomal translocations and fusion genes in leukemia-lymphoma cell lines. Leukemia 1995; 9: 480-500.
-
(1995)
Leukemia
, vol.9
, pp. 480-500
-
-
Drexler, H.G.1
MacLeod, R.A.2
Borkhardt, A.3
Janssen, J.W.4
-
18
-
-
5044225888
-
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
-
Weng AP, Ferrando AA, Lee W, Morris JP, Silverman LB, Sanchez-Irizarry C et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004; 306: 269-271.
-
(2004)
Science
, vol.306
, pp. 269-271
-
-
Weng, A.P.1
Ferrando, A.A.2
Lee, W.3
Morris, J.P.4
Silverman, L.B.5
Sanchez-Irizarry, C.6
-
19
-
-
0014575285
-
Nutritional requirements of human leukemic cells. Asparagine requirements and the effect of L-asparaginase
-
Lazarus H, McCoy TA, Farber S, Barell EF, Foley GE. Nutritional requirements of human leukemic cells. Asparagine requirements and the effect of L-asparaginase. Exp Cell Res 1969; 57: 134-138.
-
(1969)
Exp Cell Res
, vol.57
, pp. 134-138
-
-
Lazarus, H.1
McCoy, T.A.2
Farber, S.3
Barell, E.F.4
Foley, G.E.5
-
20
-
-
0001679798
-
Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid
-
Breitman TR, Selonick SE, Collins SJ. Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid. Proc Natl Acad Sci USA 1980; 77: 2936-2940.
-
(1980)
Proc Natl Acad Sci USA
, vol.77
, pp. 2936-2940
-
-
Breitman, T.R.1
Selonick, S.E.2
Collins, S.J.3
-
21
-
-
0031454003
-
CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins
-
Carroll M, Ohno-Jones S, Tamura S, Buchdunger E, Zimmermann J, Lydon NB et al. CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins. Blood 1997; 90: 4947-4952.
-
(1997)
Blood
, vol.90
, pp. 4947-4952
-
-
Carroll, M.1
Ohno-Jones, S.2
Tamura, S.3
Buchdunger, E.4
Zimmermann, J.5
Lydon, N.B.6
-
22
-
-
0036095957
-
Effects of anti-CD44 monoclonal antibodies on differentiation and apoptosis of human myeloid leukemia cell lines
-
Charrad RS, Gadhoum Z, Qi J, Glachant A, Allouche M, Jasmin C et al Effects of anti-CD44 monoclonal antibodies on differentiation and apoptosis of human myeloid leukemia cell lines. Blood 2002; 99 290-299.
-
(2002)
Blood
, vol.99
, pp. 290-299
-
-
Charrad, R.S.1
Gadhoum, Z.2
Qi, J.3
Glachant, A.4
Allouche, M.5
Jasmin, C.6
-
23
-
-
1342305488
-
Malignant hematopoietic cell lines: In vitro models for the study of MLL gene alterations
-
Drexler HG, Quentmeier H, MacLeod RA. Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations. Leukemia 2004; 18: 227-232.
-
(2004)
Leukemia
, vol.18
, pp. 227-232
-
-
Drexler, H.G.1
Quentmeier, H.2
MacLeod, R.A.3
-
24
-
-
0037222293
-
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia
-
Vangala RK, Heiss-Neumann MS, Rangatia JS, Singh SM, Schoch C, Tenen DG et al. The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia. Blood 2003; 101: 270-277.
-
(2003)
Blood
, vol.101
, pp. 270-277
-
-
Vangala, R.K.1
Heiss-Neumann, M.S.2
Rangatia, J.S.3
Singh, S.M.4
Schoch, C.5
Tenen, D.G.6
-
26
-
-
0022274007
-
Il-3-dependent mouse clones that express B-220 surface antigen, contain Ig genes in germ-line configuration, and generate B lymphocytes in vivo
-
Palacios R, Steinmetz M. Il-3-dependent mouse clones that express B-220 surface antigen, contain Ig genes in germ-line configuration, and generate B lymphocytes in vivo. Cell 1985; 41: 727-734.
-
(1985)
Cell
, vol.41
, pp. 727-734
-
-
Palacios, R.1
Steinmetz, M.2
-
27
-
-
0001044842
-
Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein
-
Daley GQ, Baltimore D. Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein. Proc Natl Acad Sci USA 1988; 85: 9312-9316.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 9312-9316
-
-
Daley, G.Q.1
Baltimore, D.2
-
28
-
-
33845360035
-
Ba/F3 cells and their use in kinase drug discovery
-
Warmuth M, Kim S, Gu XJ, Xia G, Adrian F. Ba/F3 cells and their use in kinase drug discovery. Curr Opin Oncol 2007; 19: 55-60.
-
(2007)
Curr Opin Oncol
, vol.19
, pp. 55-60
-
-
Warmuth, M.1
Kim, S.2
Gu, X.J.3
Xia, G.4
Adrian, F.5
-
29
-
-
25444470530
-
The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression
-
Xia ZB, Popovic R, Chen J, Theisler C, Stuart T, Santillan DA et al The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression. Proc Natl Acad Sci USA 2005; 102: 14028-14033.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 14028-14033
-
-
Xia, Z.B.1
Popovic, R.2
Chen, J.3
Theisler, C.4
Stuart, T.5
Santillan, D.A.6
-
30
-
-
0141924544
-
Leukemia-lymphoma cell lines as model systems for hematopoietic research
-
Drexler HG, MacLeod RA. Leukemia-lymphoma cell lines as model systems for hematopoietic research. Ann Med 2003; 35: 404-412.
-
(2003)
Ann Med
, vol.35
, pp. 404-412
-
-
Drexler, H.G.1
MacLeod, R.A.2
-
31
-
-
0026545967
-
bcr-abl-Induced cell lines can switch from mast cell to erythroid or myeloid differentiation in vitro
-
Elefanty AG, Cory S. bcr-abl-Induced cell lines can switch from mast cell to erythroid or myeloid differentiation in vitro. Blood 1992; 79: 1271-1281.
-
(1992)
Blood
, vol.79
, pp. 1271-1281
-
-
Elefanty, A.G.1
Cory, S.2
-
32
-
-
0034646247
-
The amino terminus of the mixed lineage leukemia protein (MLL) promotes cell cycle arrest and monocytic differentiation
-
Caslini C, Shilatifard A, Yang L, Hess JL. The amino terminus of the mixed lineage leukemia protein (MLL) promotes cell cycle arrest and monocytic differentiation. Proc Natl Acad Sci USA 2000; 97: 2797-2802.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 2797-2802
-
-
Caslini, C.1
Shilatifard, A.2
Yang, L.3
Hess, J.L.4
-
33
-
-
0033611566
-
Establishment of an inducible expression system of chimeric MLL-LTG9 protein and inhibition of Hox a7, Hox b7 and Hox c9 expression by MLL-LTG9 in 32Dcl3 cells
-
Joh T, Hosokawa Y, Suzuki R, Takahashi T, Seto M. Establishment of an inducible expression system of chimeric MLL-LTG9 protein and inhibition of Hox a7, Hox b7 and Hox c9 expression by MLL-LTG9 in 32Dcl3 cells. Oncogene 1999; 18, 1125-1130.
-
(1999)
Oncogene
, vol.18
, pp. 1125-1130
-
-
Joh, T.1
Hosokawa, Y.2
Suzuki, R.3
Takahashi, T.4
Seto, M.5
-
34
-
-
0041370095
-
Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9
-
Ayton PM, Cleary ML. Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9. Genes Dev 2003; 17: 2298-2307.
-
(2003)
Genes Dev
, vol.17
, pp. 2298-2307
-
-
Ayton, P.M.1
Cleary, M.L.2
-
35
-
-
34247595838
-
Modeling the initiation and progression of human acute leukemia in mice
-
Barabé F, Kennedy JA, Hope KJ, Dick JE. Modeling the initiation and progression of human acute leukemia in mice. Science 2007; 316 600-604.
-
(2007)
Science
, vol.316
, pp. 600-604
-
-
Barabé, F.1
Kennedy, J.A.2
Hope, K.J.3
Dick, J.E.4
-
36
-
-
0037071401
-
Modelling haematopoietic malignancies in the mouse and therapeutical implications
-
Bernardi R, Grisendi S, Pandolfi PP. Modelling haematopoietic malignancies in the mouse and therapeutical implications. Oncogene 2002; 21: 3445-3458.
-
(2002)
Oncogene
, vol.21
, pp. 3445-3458
-
-
Bernardi, R.1
Grisendi, S.2
Pandolfi, P.P.3
-
37
-
-
0025209916
-
Acute leukaemia in bcr/abl transgenic mice
-
Heisterkamp N, Jenster G, ten Hoeve J, Zovich D, Pattengale PK, Groffen J. Acute leukaemia in bcr/abl transgenic mice. Nature 1990; 344 251-253.
-
(1990)
Nature
, vol.344
, pp. 251-253
-
-
Heisterkamp, N.1
Jenster, G.2
ten Hoeve, J.3
Zovich, D.4
Pattengale, P.K.5
Groffen, J.6
-
38
-
-
0022380768
-
The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
-
Adams JM, Harris AW, Pinkert CA, Corcoran LM, Alexander WS, Cory S et al. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 1985; 318: 533-538.
-
(1985)
Nature
, vol.318
, pp. 533-538
-
-
Adams, J.M.1
Harris, A.W.2
Pinkert, C.A.3
Corcoran, L.M.4
Alexander, W.S.5
Cory, S.6
-
39
-
-
0031000207
-
Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice
-
He LZ, Tribioli C, Rivi R, Peruzzi D, Pelicci PG, Soares V et al. Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice. Proc Natl Acad Sci USA 1997; 94: 5302-5307.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 5302-5307
-
-
He, L.Z.1
Tribioli, C.2
Rivi, R.3
Peruzzi, D.4
Pelicci, P.G.5
Soares, V.6
-
40
-
-
0031025416
-
Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene
-
Yergeau DA, Hetherington CJ, Wang Q, Zhang P, Sharpe AH, Binder M et al. Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene. Nat Genet 1997; 15 303-306.
-
(1997)
Nat Genet
, vol.15
, pp. 303-306
-
-
Yergeau, D.A.1
Hetherington, C.J.2
Wang, Q.3
Zhang, P.4
Sharpe, A.H.5
Binder, M.6
-
41
-
-
0036463950
-
Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia
-
Higuchi M, O'Brien D, Kumaravelu P, Lenny N, Yeoh EJ, Downing JR. Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia. Cancer Cell 2002; 1: 63-74.
-
(2002)
Cancer Cell
, vol.1
, pp. 63-74
-
-
Higuchi, M.1
O'Brien, D.2
Kumaravelu, P.3
Lenny, N.4
Yeoh, E.J.5
Downing, J.R.6
-
42
-
-
1542464838
-
Transgenics at breaking-point
-
Prosser H, Bradley A. Transgenics at breaking-point. Cancer Cell 2003; 3: 411-413.
-
(2003)
Cancer Cell
, vol.3
, pp. 411-413
-
-
Prosser, H.1
Bradley, A.2
-
43
-
-
18744412961
-
The invertor knock-in conditional chromosomal translocation mimic
-
Forster A, Pannell R, Drynan LF, Codrington R, Daser A, Metzler M et al. The invertor knock-in conditional chromosomal translocation mimic. Nat Methods 2005; 2: 27-30.
-
(2005)
Nat Methods
, vol.2
, pp. 27-30
-
-
Forster, A.1
Pannell, R.2
Drynan, L.F.3
Codrington, R.4
Daser, A.5
Metzler, M.6
-
44
-
-
0345582392
-
Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer
-
Forster A, Pannell R, Drynan LF, McCormack M, Collins EC, Daser A et al. Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer. Cancer Cell 2003; 3: 449-458.
-
(2003)
Cancer Cell
, vol.3
, pp. 449-458
-
-
Forster, A.1
Pannell, R.2
Drynan, L.F.3
McCormack, M.4
Collins, E.C.5
Daser, A.6
-
45
-
-
27144493049
-
Mll fusions generated by Cre-loxP-mediated de novo translocations can induce lineage reassignment in tumorigenesis
-
Drynan LF, Pannell R, Forster A, Chan NM, Cano F, Daser A et al. Mll fusions generated by Cre-loxP-mediated de novo translocations can induce lineage reassignment in tumorigenesis. EMBO J 2005; 24 3136-3146.
-
(2005)
EMBO J
, vol.24
, pp. 3136-3146
-
-
Drynan, L.F.1
Pannell, R.2
Forster, A.3
Chan, N.M.4
Cano, F.5
Daser, A.6
-
46
-
-
0030791974
-
Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL
-
Lavau C, Szilvassy SJ, Slany R, Cleary ML. Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL. EMBO J 1997; 16: 4226-4237.
-
(1997)
EMBO J
, vol.16
, pp. 4226-4237
-
-
Lavau, C.1
Szilvassy, S.J.2
Slany, R.3
Cleary, M.L.4
-
47
-
-
0025117392
-
Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome
-
Daley GQ, Van Etten RA, Baltimore D. Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science 1990; 247: 824-830.
-
(1990)
Science
, vol.247
, pp. 824-830
-
-
Daley, G.Q.1
Van Etten, R.A.2
Baltimore, D.3
-
48
-
-
0032533257
-
Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow
-
Pear WS, Miller JP, Xu L, Pui JC, Soffer B, Quackenbush RC et al. Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. Blood 1998; 92: 3780-3792.
-
(1998)
Blood
, vol.92
, pp. 3780-3792
-
-
Pear, W.S.1
Miller, J.P.2
Xu, L.3
Pui, J.C.4
Soffer, B.5
Quackenbush, R.C.6
-
49
-
-
0348140592
-
Modeling the dosage effect of oncogenes in leukemogenesis
-
Ren R. Modeling the dosage effect of oncogenes in leukemogenesis. Curr Opin Hematol 2004; 11: 25-34.
-
(2004)
Curr Opin Hematol
, vol.11
, pp. 25-34
-
-
Ren, R.1
-
50
-
-
0032126633
-
Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b
-
Kroon E, Krosl J, Thorsteinsdottir U, Baban S, Buchberg AM, Sauvageau G. Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b. EMBO J 1998; 17: 3714-3725.
-
(1998)
EMBO J
, vol.17
, pp. 3714-3725
-
-
Kroon, E.1
Krosl, J.2
Thorsteinsdottir, U.3
Baban, S.4
Buchberg, A.M.5
Sauvageau, G.6
-
51
-
-
33745057158
-
STAT5 signaling is required for the efficient induction and maintenance of CML in mice
-
Ye D, Wolff N, Li L, Zhang S, Ilaria Jr RL. STAT5 signaling is required for the efficient induction and maintenance of CML in mice. Blood 2006; 107: 4917-4925.
-
(2006)
Blood
, vol.107
, pp. 4917-4925
-
-
Ye, D.1
Wolff, N.2
Li, L.3
Zhang, S.4
Ilaria Jr, R.L.5
-
52
-
-
0346100567
-
Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors
-
Cozzio A, Passegue E, Ayton PM, Karsunky H, Cleary ML, Weissman IL. Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev 2003; 17: 3029-3035.
-
(2003)
Genes Dev
, vol.17
, pp. 3029-3035
-
-
Cozzio, A.1
Passegue, E.2
Ayton, P.M.3
Karsunky, H.4
Cleary, M.L.5
Weissman, I.L.6
-
53
-
-
19944385935
-
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors
-
Huntly BJ, Shigematsu H, Deguchi K, Lee BH, Mizuno S, Duclos N et al MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors. Cancer Cell 2004; 6: 587-596.
-
(2004)
Cancer Cell
, vol.6
, pp. 587-596
-
-
Huntly, B.J.1
Shigematsu, H.2
Deguchi, K.3
Lee, B.H.4
Mizuno, S.5
Duclos, N.6
-
54
-
-
10944235028
-
Chronic versus acute myelogenous leukemia: A question of self-renewal
-
Jamieson CH, Weissman IL, Passegue E. Chronic versus acute myelogenous leukemia: A question of self-renewal. Cancer Cell 2004; 6: 531-533.
-
(2004)
Cancer Cell
, vol.6
, pp. 531-533
-
-
Jamieson, C.H.1
Weissman, I.L.2
Passegue, E.3
-
56
-
-
0020520516
-
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
-
Land H, Parada LF, Weinberg RA. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature 1983; 304: 596-602.
-
(1983)
Nature
, vol.304
, pp. 596-602
-
-
Land, H.1
Parada, L.F.2
Weinberg, R.A.3
-
57
-
-
0020520517
-
Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture
-
Ruley HE. Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture. Nature 1983; 304: 602-606.
-
(1983)
Nature
, vol.304
, pp. 602-606
-
-
Ruley, H.E.1
-
58
-
-
4344646902
-
Species- and cell type-specific requirements for cellular transformation
-
Rangarajan A, Hong SJ, Gifford A, Weinberg RA. Species- and cell type-specific requirements for cellular transformation. Cancer Cell 2004; 6: 171-183.
-
(2004)
Cancer Cell
, vol.6
, pp. 171-183
-
-
Rangarajan, A.1
Hong, S.J.2
Gifford, A.3
Weinberg, R.A.4
-
59
-
-
0028564951
-
Specific association of human telomerase activity with immortal cells and cancer
-
Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL et al. Specific association of human telomerase activity with immortal cells and cancer. Science 1994; 266: 2011-2015.
-
(1994)
Science
, vol.266
, pp. 2011-2015
-
-
Kim, N.W.1
Piatyszek, M.A.2
Prowse, K.R.3
Harley, C.B.4
West, M.D.5
Ho, P.L.6
-
60
-
-
0036362266
-
Telomerase and differentiation in multicellular organisms: Turn it off, turn it on, and turn it off again
-
Forsyth NR, Wright WE, Shay JW. Telomerase and differentiation in multicellular organisms: Turn it off, turn it on, and turn it off again. Differentiation 2002; 69: 188-197.
-
(2002)
Differentiation
, vol.69
, pp. 188-197
-
-
Forsyth, N.R.1
Wright, W.E.2
Shay, J.W.3
-
61
-
-
1342288971
-
Opinion: Comparative biology of mouse versus human cells: Modelling human cancer in mice
-
Rangarajan A, Weinberg RA. Opinion: Comparative biology of mouse versus human cells: Modelling human cancer in mice. Nat Rev Cancer 2003; 3: 952-959.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 952-959
-
-
Rangarajan, A.1
Weinberg, R.A.2
-
62
-
-
1642276757
-
A dominant-negative mutant of C/EBPalpha, associated with acute myeloid leukemias, inhibits differentiation of myeloid and erythroid progenitors of man but not mouse
-
Schwieger M, Lohler J, Fischer M, Herwig U, Tenen DG, Stocking C. A dominant-negative mutant of C/EBPalpha, associated with acute myeloid leukemias, inhibits differentiation of myeloid and erythroid progenitors of man but not mouse. Blood 2004; 103: 2744-2752.
-
(2004)
Blood
, vol.103
, pp. 2744-2752
-
-
Schwieger, M.1
Lohler, J.2
Fischer, M.3
Herwig, U.4
Tenen, D.G.5
Stocking, C.6
-
63
-
-
37849004512
-
Genetic background and the dilemma of translating mouse studies to humans
-
Rivera J, Tessarollo L. Genetic background and the dilemma of translating mouse studies to humans. Immunity 2008; 28: 1-4.
-
(2008)
Immunity
, vol.28
, pp. 1-4
-
-
Rivera, J.1
Tessarollo, L.2
-
64
-
-
0030916733
-
Primitive human hematopoietic cells are enriched in cord blood compared with adult bone marrow or mobilized peripheral blood as measured by the quantitative in vivo SCID-repopulating cell assay
-
Wang JC, Doedens M, Dick JE. Primitive human hematopoietic cells are enriched in cord blood compared with adult bone marrow or mobilized peripheral blood as measured by the quantitative in vivo SCID-repopulating cell assay. Blood 1997; 89: 3919-3924.
-
(1997)
Blood
, vol.89
, pp. 3919-3924
-
-
Wang, J.C.1
Doedens, M.2
Dick, J.E.3
-
65
-
-
0028385758
-
Versatile retroviral vectors for potential use in gene therapy
-
Hawley RG, Lieu FH, Fong AZ, Hawley TS. Versatile retroviral vectors for potential use in gene therapy. Gene Therapy 1994; 1: 136-138.
-
(1994)
Gene Therapy
, vol.1
, pp. 136-138
-
-
Hawley, R.G.1
Lieu, F.H.2
Fong, A.Z.3
Hawley, T.S.4
-
66
-
-
0030903188
-
Mutant N-RAS induces erythroid lineage dysplasia in human CD34+ cells
-
Darley RL, Hoy TG, Baines P, Padua RA, Burnett AK. Mutant N-RAS induces erythroid lineage dysplasia in human CD34+ cells. J Exp Med 1997; 185: 1337-1347.
-
(1997)
J Exp Med
, vol.185
, pp. 1337-1347
-
-
Darley, R.L.1
Hoy, T.G.2
Baines, P.3
Padua, R.A.4
Burnett, A.K.5
-
67
-
-
4444350859
-
Mutant N-ras preferentially drives human CD34+ hematopoietic progenitor cells into myeloid differentiation and proliferation both in vitro and in the NOD/SCID mouse
-
Shen SW, Dolnikov A, Passioura T, Millington M, Wotherspoon S, Rice A et al. Mutant N-ras preferentially drives human CD34+ hematopoietic progenitor cells into myeloid differentiation and proliferation both in vitro and in the NOD/SCID mouse. Exp Hematol 2004; 32: 852-860.
-
(2004)
Exp Hematol
, vol.32
, pp. 852-860
-
-
Shen, S.W.1
Dolnikov, A.2
Passioura, T.3
Millington, M.4
Wotherspoon, S.5
Rice, A.6
-
68
-
-
27144477007
-
Direct evidence for cooperating genetic events in the leukemic transformation of normal human hematopoietic cells
-
Warner JK, Wang JC, Takenaka K, Doulatov S, McKenzie JL, Harrington L et al. Direct evidence for cooperating genetic events in the leukemic transformation of normal human hematopoietic cells. Leukemia 2005; 19: 1794-1805.
-
(2005)
Leukemia
, vol.19
, pp. 1794-1805
-
-
Warner, J.K.1
Wang, J.C.2
Takenaka, K.3
Doulatov, S.4
McKenzie, J.L.5
Harrington, L.6
-
69
-
-
0032493377
-
Retroviral transduction of TLS-ERG initiates a leukemogenic program in normal human hematopoietic cells
-
Pereira DS, Dorrell C, Ito CY, Gan OI, Murdoch B, Rao VN et al. Retroviral transduction of TLS-ERG initiates a leukemogenic program in normal human hematopoietic cells. Proc Natl Acad Sci USA 1998; 95: 8239-8244.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 8239-8244
-
-
Pereira, D.S.1
Dorrell, C.2
Ito, C.Y.3
Gan, O.I.4
Murdoch, B.5
Rao, V.N.6
-
70
-
-
0034663431
-
PML/RAR alpha fusion protein expression in normal human hematopoietic progenitors dictates myeloid commitment and the promyelocytic phenotype
-
Grignani F, Valtieri M, Gabbianelli M, Gelmetti V, Botta R, Luchetti L et al. PML/RAR alpha fusion protein expression in normal human hematopoietic progenitors dictates myeloid commitment and the promyelocytic phenotype. Blood 2000; 96: 1531-1537.
-
(2000)
Blood
, vol.96
, pp. 1531-1537
-
-
Grignani, F.1
Valtieri, M.2
Gabbianelli, M.3
Gelmetti, V.4
Botta, R.5
Luchetti, L.6
-
71
-
-
0035871680
-
Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo
-
Buske C, Feuring-Buske M, Antonchuk J, Rosten P, Hogge DE, Eaves CJ et al. Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo. Blood 2001; 97: 2286-2292.
-
(2001)
Blood
, vol.97
, pp. 2286-2292
-
-
Buske, C.1
Feuring-Buske, M.2
Antonchuk, J.3
Rosten, P.4
Hogge, D.E.5
Eaves, C.J.6
-
72
-
-
0036565871
-
Modulation of p210(BCR-ABL) activity in transduced primary human hematopoietic cells controls lineage programming
-
Chalandon Y, Jiang X, Hazlewood G, Loutet S, Conneally E, Eaves A et al. Modulation of p210(BCR-ABL) activity in transduced primary human hematopoietic cells controls lineage programming. Blood 2002; 99: 3197-3204.
-
(2002)
Blood
, vol.99
, pp. 3197-3204
-
-
Chalandon, Y.1
Jiang, X.2
Hazlewood, G.3
Loutet, S.4
Conneally, E.5
Eaves, A.6
-
73
-
-
0037443154
-
Induction of C/EBPalpha activity alters gene expression and differentiation of human CD34+ cells
-
Cammenga J, Mulloy JC, Berguido FJ, MacGrogan D, Viale A, Nimer SD. Induction of C/EBPalpha activity alters gene expression and differentiation of human CD34+ cells. Blood 2003; 101: 2206-2214.
-
(2003)
Blood
, vol.101
, pp. 2206-2214
-
-
Cammenga, J.1
Mulloy, J.C.2
Berguido, F.J.3
MacGrogan, D.4
Viale, A.5
Nimer, S.D.6
-
74
-
-
0345167904
-
Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element
-
Mulloy JC, Cammenga J, Berguido FJ, Wu K, Zhou P, Comenzo RL et al. Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element. Blood 2003; 102: 4369-4376.
-
(2003)
Blood
, vol.102
, pp. 4369-4376
-
-
Mulloy, J.C.1
Cammenga, J.2
Berguido, F.J.3
Wu, K.4
Zhou, P.5
Comenzo, R.L.6
-
75
-
-
13244292308
-
AML1/ETO promotes the maintenance of early hematopoietic progenitors in NOD/SCID mice but does not abrogate their lineage specific differentiation
-
Basecke J, Schwieger M, Griesinger F, Schiedlmeier B, Wulf G, Trumper L et al. AML1/ETO promotes the maintenance of early hematopoietic progenitors in NOD/SCID mice but does not abrogate their lineage specific differentiation. Leuk Lymphoma 2005; 46: 265-272.
-
(2005)
Leuk Lymphoma
, vol.46
, pp. 265-272
-
-
Basecke, J.1
Schwieger, M.2
Griesinger, F.3
Schiedlmeier, B.4
Wulf, G.5
Trumper, L.6
-
76
-
-
11144235821
-
Enforced expression of an Flt3 internal tandem duplication in human CD34+ cells confers properties of self-renewal and enhanced erythropoiesis
-
Chung KY, Morrone G, Schuringa JJ, Wong B, Dorn DC, Moore MA. Enforced expression of an Flt3 internal tandem duplication in human CD34+ cells confers properties of self-renewal and enhanced erythropoiesis. Blood 2005; 105: 77-84.
-
(2005)
Blood
, vol.105
, pp. 77-84
-
-
Chung, K.Y.1
Morrone, G.2
Schuringa, J.J.3
Wong, B.4
Dorn, D.C.5
Moore, M.A.6
-
77
-
-
4944262287
-
Constitutively active Notch4 promotes early human hematopoietic progenitor cell maintenance while inhibiting differentiation and causes lymphoid abnormalities in vivo
-
Vercauteren SM, Sutherland HJ. Constitutively active Notch4 promotes early human hematopoietic progenitor cell maintenance while inhibiting differentiation and causes lymphoid abnormalities in vivo. Blood 2004; 104: 2315-2322.
-
(2004)
Blood
, vol.104
, pp. 2315-2322
-
-
Vercauteren, S.M.1
Sutherland, H.J.2
-
78
-
-
33748176403
-
Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability
-
Wunderlich M, Krejci O, Wei J, Mulloy JC. Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability. Blood 2006; 108: 1690-1697.
-
(2006)
Blood
, vol.108
, pp. 1690-1697
-
-
Wunderlich, M.1
Krejci, O.2
Wei, J.3
Mulloy, J.C.4
-
79
-
-
33750936941
-
Expression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivo
-
Kennedy JA, Barabé F, Patterson BJ, Bayani J, Squire JA, Barber DL et al. Expression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivo. Proc Natl Acad Sci USA 2006; 103: 16930-16935.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 16930-16935
-
-
Kennedy, J.A.1
Barabé, F.2
Patterson, B.J.3
Bayani, J.4
Squire, J.A.5
Barber, D.L.6
-
80
-
-
33846199172
-
Enforced expression of NUP98-HOXA9 in human CD34(+) cells enhances stem cell proliferation
-
Chung KY, Morrone G, Schuringa JJ, Plasilova M, Shieh JH, Zhang Y et al. Enforced expression of NUP98-HOXA9 in human CD34(+) cells enhances stem cell proliferation. Cancer Res 2006; 66: 11781-11791.
-
(2006)
Cancer Res
, vol.66
, pp. 11781-11791
-
-
Chung, K.Y.1
Morrone, G.2
Schuringa, J.J.3
Plasilova, M.4
Shieh, J.H.5
Zhang, Y.6
-
81
-
-
33746167484
-
NUP98-HOXA9 induces long-term proliferation and blocks differentiation of primary human CD34+ hematopoietic cells
-
Takeda A, Goolsby C, Yaseen NR. NUP98-HOXA9 induces long-term proliferation and blocks differentiation of primary human CD34+ hematopoietic cells. Cancer Res 2006; 66: 6628-6637.
-
(2006)
Cancer Res
, vol.66
, pp. 6628-6637
-
-
Takeda, A.1
Goolsby, C.2
Yaseen, N.R.3
-
82
-
-
33947395708
-
Ectopic retroviral expression of LMO2, but not IL2Rgamma, blocks human T-cell development from CD34+ cells: Implications for leukemogenesis in gene therapy
-
Pike-Overzet K, de Ridder D, Weerkamp F, Baert MR, Verstegen MM, Brugman MH et al. Ectopic retroviral expression of LMO2, but not IL2Rgamma, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy. Leukemia 2007; 21: 754-763.
-
(2007)
Leukemia
, vol.21
, pp. 754-763
-
-
Pike-Overzet, K.1
de Ridder, D.2
Weerkamp, F.3
Baert, M.R.4
Verstegen, M.M.5
Brugman, M.H.6
-
83
-
-
28844494334
-
The inv(16) cooperates with ARF haploinsufficiency to induce acute myeloid leukemia
-
Moreno-Miralles I, Pan L, Keates-Baleeiro J, Durst-Goodwin K, Yang C, Kim HG et al. The inv(16) cooperates with ARF haploinsufficiency to induce acute myeloid leukemia. J Biol Chem 2005; 280: 40097-40103.
-
(2005)
J Biol Chem
, vol.280
, pp. 40097-40103
-
-
Moreno-Miralles, I.1
Pan, L.2
Keates-Baleeiro, J.3
Durst-Goodwin, K.4
Yang, C.5
Kim, H.G.6
-
84
-
-
30344446665
-
Cbf beta-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia
-
Kuo YH, Landrette SF, Heilman SA, Perrat PN, Garrett L, Liu PP et al Cbf beta-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia. Cancer Cell 2006; 9: 57-68.
-
(2006)
Cancer Cell
, vol.9
, pp. 57-68
-
-
Kuo, Y.H.1
Landrette, S.F.2
Heilman, S.A.3
Perrat, P.N.4
Garrett, L.5
Liu, P.P.6
-
85
-
-
33744466770
-
STAT5-induced self-renewal and impaired myelopoiesis of human hematopoietic stem/progenitor cells involves down-modulation of C/ EBPalpha
-
Wierenga AT, Schepers H, Moore MA, Vellenga E, Schuringa JJ. STAT5-induced self-renewal and impaired myelopoiesis of human hematopoietic stem/progenitor cells involves down-modulation of C/ EBPalpha. Blood 2006; 107: 4326-4333.
-
(2006)
Blood
, vol.107
, pp. 4326-4333
-
-
Wierenga, A.T.1
Schepers, H.2
Moore, M.A.3
Vellenga, E.4
Schuringa, J.J.5
-
86
-
-
0024213526
-
Engraftment of immune-deficient mice with human hematopoietic stem cells
-
Kamel-Reid S, Dick JE. Engraftment of immune-deficient mice with human hematopoietic stem cells. Science 1988; 242: 1706-1709.
-
(1988)
Science
, vol.242
, pp. 1706-1709
-
-
Kamel-Reid, S.1
Dick, J.E.2
-
87
-
-
0026581239
-
Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in SCID mice
-
Lapidot T, Pflumio F, Doedens M, Murdoch B, Williams DE, Dick JE. Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in SCID mice. Science 1992; 255: 1137-1141.
-
(1992)
Science
, vol.255
, pp. 1137-1141
-
-
Lapidot, T.1
Pflumio, F.2
Doedens, M.3
Murdoch, B.4
Williams, D.E.5
Dick, J.E.6
-
88
-
-
0028281703
-
Immature human cord blood progenitors engraft and proliferate to high levels in severe combined immunodeficient mice
-
Vormoor J, Lapidot T, Pflumio F, Risdon G, Patterson B, Broxmeyer HE et al. Immature human cord blood progenitors engraft and proliferate to high levels in severe combined immunodeficient mice. Blood 1994; 83: 2489-2497.
-
(1994)
Blood
, vol.83
, pp. 2489-2497
-
-
Vormoor, J.1
Lapidot, T.2
Pflumio, F.3
Risdon, G.4
Patterson, B.5
Broxmeyer, H.E.6
-
89
-
-
0030911358
-
Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice
-
Bhatia M, Wang JC, Kapp U, Bonnet D, Dick JE. Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice. Proc Natl Acad Sci USA 1997; 94: 5320-5325.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 5320-5325
-
-
Bhatia, M.1
Wang, J.C.2
Kapp, U.3
Bonnet, D.4
Dick, J.E.5
-
90
-
-
0028869986
-
Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice
-
Shultz LD, Schweitzer PA, Christianson SW, Gott B, Schweitzer IB, Tennent B et al. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. J Immunol 1995; 154 180-191.
-
(1995)
J Immunol
, vol.154
, pp. 180-191
-
-
Shultz, L.D.1
Schweitzer, P.A.2
Christianson, S.W.3
Gott, B.4
Schweitzer, I.B.5
Tennent, B.6
-
91
-
-
16144365969
-
Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy
-
Larochelle A, Vormoor J, Hanenberg H, Wang JC, Bhatia M, Lapidot T et al. Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy. Nat Med 1996; 2: 1329-1337.
-
(1996)
Nat Med
, vol.2
, pp. 1329-1337
-
-
Larochelle, A.1
Vormoor, J.2
Hanenberg, H.3
Wang, J.C.4
Bhatia, M.5
Lapidot, T.6
-
92
-
-
0037783434
-
A highly sensitive strategy for SCID-repopulating cell assay by direct injection of primitive human hematopoietic cells into NOD/SCID mice bone marrow
-
Yahata T, Ando K, Sato T, Miyatake H, Nakamura Y, Muguruma Y et al A highly sensitive strategy for SCID-repopulating cell assay by direct injection of primitive human hematopoietic cells into NOD/SCID mice bone marrow. Blood 2003; 101: 2905-2913.
-
(2003)
Blood
, vol.101
, pp. 2905-2913
-
-
Yahata, T.1
Ando, K.2
Sato, T.3
Miyatake, H.4
Nakamura, Y.5
Muguruma, Y.6
-
93
-
-
0038379165
-
Rapid myeloerythroid repopulation after intrafemoral transplantation of NOD-SCID mice reveals a new class of human stem cells
-
Mazurier F, Doedens M, Gan OI, Dick JE. Rapid myeloerythroid repopulation after intrafemoral transplantation of NOD-SCID mice reveals a new class of human stem cells. Nat Med 2003; 9: 959-963.
-
(2003)
Nat Med
, vol.9
, pp. 959-963
-
-
Mazurier, F.1
Doedens, M.2
Gan, O.I.3
Dick, J.E.4
-
94
-
-
23744441612
-
Human short-term repopulating stem cells are efficiently detected following intrafemoral transplantation into NOD/SCID recipients depleted of CD122+ cells
-
McKenzie JL, Gan OI, Doedens M, Dick JE. Human short-term repopulating stem cells are efficiently detected following intrafemoral transplantation into NOD/SCID recipients depleted of CD122+ cells. Blood 2005; 106: 1259-1261.
-
(2005)
Blood
, vol.106
, pp. 1259-1261
-
-
McKenzie, J.L.1
Gan, O.I.2
Doedens, M.3
Dick, J.E.4
-
95
-
-
1842588698
-
Development of a human adaptive immune system in cord blood cell-transplanted mice
-
Traggiai E, Chicha L, Mazzucchelli L, Bronz L, Piffaretti JC, Lanzavecchia A et al. Development of a human adaptive immune system in cord blood cell-transplanted mice. Science 2004; 304 104-107.
-
(2004)
Science
, vol.304
, pp. 104-107
-
-
Traggiai, E.1
Chicha, L.2
Mazzucchelli, L.3
Bronz, L.4
Piffaretti, J.C.5
Lanzavecchia, A.6
-
96
-
-
0024787012
-
A model of human acute lymphoblastic leukemia in immune-deficient SCID mice
-
Kamel-Reid S, Letarte M, Sirard C, Doedens M, Grunberger T, Fulop G et al. A model of human acute lymphoblastic leukemia in immune-deficient SCID mice. Science 1989; 246: 1597-1600.
-
(1989)
Science
, vol.246
, pp. 1597-1600
-
-
Kamel-Reid, S.1
Letarte, M.2
Sirard, C.3
Doedens, M.4
Grunberger, T.5
Fulop, G.6
-
97
-
-
0028091194
-
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
-
Lapidot T, Sirard C, Vormoor J, Murdoch B, Hoang T, Caceres-Cortes J et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 1994; 367: 645-648.
-
(1994)
Nature
, vol.367
, pp. 645-648
-
-
Lapidot, T.1
Sirard, C.2
Vormoor, J.3
Murdoch, B.4
Hoang, T.5
Caceres-Cortes, J.6
-
98
-
-
0033044933
-
Prognostic significance of T-lineage leukemic cell growth in SCID mice: A Children's Cancer Group study
-
Uckun FM, Waurzyniak BJ, Sather HN, Sensel MG, Chelstrom L, Nachman J et al. Prognostic significance of T-lineage leukemic cell growth in SCID mice: A Children's Cancer Group study. Leuk Lymphoma 1999; 32: 475-487.
-
(1999)
Leuk Lymphoma
, vol.32
, pp. 475-487
-
-
Uckun, F.M.1
Waurzyniak, B.J.2
Sather, H.N.3
Sensel, M.G.4
Chelstrom, L.5
Nachman, J.6
-
99
-
-
31544436322
-
AML engraftment in the NOD/SCID assay reflects the outcome of AML: Implications for our understanding of the heterogeneity of AML
-
Pearce DJ, Taussig D, Zibara K, Smith LL, Ridler CM, Preudhomme C et al. AML engraftment in the NOD/SCID assay reflects the outcome of AML: Implications for our understanding of the heterogeneity of AML. Blood 2006; 107: 1166-1173.
-
(2006)
Blood
, vol.107
, pp. 1166-1173
-
-
Pearce, D.J.1
Taussig, D.2
Zibara, K.3
Smith, L.L.4
Ridler, C.M.5
Preudhomme, C.6
-
100
-
-
0036739791
-
Human AML cells in NOD/SCID mice: Engraftment potential and gene expression
-
Lumkul R, Gorin NC, Malehorn MT, Hoehn GT, Zheng R, Baldwin B et al Human AML cells in NOD/SCID mice: Engraftment potential and gene expression. Leukemia 2002; 16: 1818-1826.
-
(2002)
Leukemia
, vol.16
, pp. 1818-1826
-
-
Lumkul, R.1
Gorin, N.C.2
Malehorn, M.T.3
Hoehn, G.T.4
Zheng, R.5
Baldwin, B.6
-
101
-
-
0033067551
-
Ligation of the CD44 adhesion molecule reverses blockage of differentiation in human acute myeloid leukemia
-
Charrad RS, Li Y, Delpech B, Balitrand N, Clay D, Jasmin C et al. Ligation of the CD44 adhesion molecule reverses blockage of differentiation in human acute myeloid leukemia. Nat Med 1999; 5: 669-676.
-
(1999)
Nat Med
, vol.5
, pp. 669-676
-
-
Charrad, R.S.1
Li, Y.2
Delpech, B.3
Balitrand, N.4
Clay, D.5
Jasmin, C.6
-
102
-
-
33749515476
-
Targeting of CD44 eradicates human acute myeloid leukemic stem cells
-
Jin L, Hope KJ, Zhai Q, Smadja-Joffe F, Dick JE. Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat Med 2006; 12: 1167-1174.
-
(2006)
Nat Med
, vol.12
, pp. 1167-1174
-
-
Jin, L.1
Hope, K.J.2
Zhai, Q.3
Smadja-Joffe, F.4
Dick, J.E.5
-
103
-
-
13744255245
-
CXCR4 regulates migration and development of human acute myelogenous leukemia stem cells in transplanted NOD/SCID mice
-
Tavor S, Petit I, Porozov S, Avigdor A, Dar A, Leider-Trejo L et al CXCR4 regulates migration and development of human acute myelogenous leukemia stem cells in transplanted NOD/SCID mice. Cancer Res 2004; 64: 2817-2824.
-
(2004)
Cancer Res
, vol.64
, pp. 2817-2824
-
-
Tavor, S.1
Petit, I.2
Porozov, S.3
Avigdor, A.4
Dar, A.5
Leider-Trejo, L.6
-
104
-
-
0030789242
-
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
-
Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997; 3: 730-737.
-
(1997)
Nat Med
, vol.3
, pp. 730-737
-
-
Bonnet, D.1
Dick, J.E.2
-
105
-
-
0033198630
-
Growth characteristics of acute myelogenous leukemia progenitors that initiate malignant hematopoiesis in nonobese diabetic/severe combined immunodeficient mice
-
Ailles LE, Gerhard B, Kawagoe H, Hogge DE. Growth characteristics of acute myelogenous leukemia progenitors that initiate malignant hematopoiesis in nonobese diabetic/severe combined immunodeficient mice. Blood 1999; 94: 1761-1772.
-
(1999)
Blood
, vol.94
, pp. 1761-1772
-
-
Ailles, L.E.1
Gerhard, B.2
Kawagoe, H.3
Hogge, D.E.4
-
106
-
-
35948984135
-
Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region
-
Ishikawa F, Yoshida S, Saito Y, Hijikata A, Kitamura H, Tanaka S et al. Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region. Nat Biotechnol 2007; 25: 1315-1321.
-
(2007)
Nat Biotechnol
, vol.25
, pp. 1315-1321
-
-
Ishikawa, F.1
Yoshida, S.2
Saito, Y.3
Hijikata, A.4
Kitamura, H.5
Tanaka, S.6
-
107
-
-
33846242910
-
Characterization of a progenitor cell population in childhood T-cell acute lymphoblastic leukemia
-
Cox CV, Martin HM, Kearns PR, Virgo P, Evely RS, Blair A. Characterization of a progenitor cell population in childhood T-cell acute lymphoblastic leukemia. Blood 2007; 109: 674-682.
-
(2007)
Blood
, vol.109
, pp. 674-682
-
-
Cox, C.V.1
Martin, H.M.2
Kearns, P.R.3
Virgo, P.4
Evely, R.S.5
Blair, A.6
-
108
-
-
20944434753
-
Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia
-
Castor A, Nilsson L, Astrand-Grundstrom I, Buitenhuis M, Ramirez C, Anderson K et al. Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia. Nat Med 2005; 11 630-637.
-
(2005)
Nat Med
, vol.11
, pp. 630-637
-
-
Castor, A.1
Nilsson, L.2
Astrand-Grundstrom, I.3
Buitenhuis, M.4
Ramirez, C.5
Anderson, K.6
-
109
-
-
45149133254
-
CD34+CD38+CD19+ as well as CD34+CD38-CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL
-
Kong Y, Yoshida S, Saito Y, Doi T, Nagatoshi Y, Fukata M et al. CD34+CD38+CD19+ as well as CD34+CD38-CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL. Leukemia 2008; 22: 1207-1213.
-
(2008)
Leukemia
, vol.22
, pp. 1207-1213
-
-
Kong, Y.1
Yoshida, S.2
Saito, Y.3
Doi, T.4
Nagatoshi, Y.5
Fukata, M.6
-
110
-
-
34547113747
-
Tumor growth need not be driven by rare cancer stem cells
-
Kelly PN, Dakic A, Adams JM, Nutt SL, Strasser A. Tumor growth need not be driven by rare cancer stem cells. Science 2007; 317: 337.
-
(2007)
Science
, vol.317
, pp. 337
-
-
Kelly, P.N.1
Dakic, A.2
Adams, J.M.3
Nutt, S.L.4
Strasser, A.5
-
111
-
-
37249044166
-
Comment on 'Tumor growth need not be driven by rare cancer stem cells'
-
Kennedy JA, Barabé F, Poeppl AG, Wang JC, Dick JE. Comment on 'Tumor growth need not be driven by rare cancer stem cells'. Science 2007; 318: 1722.
-
(2007)
Science
, vol.318
, pp. 1722
-
-
Kennedy, J.A.1
Barabé, F.2
Poeppl, A.G.3
Wang, J.C.4
Dick, J.E.5
-
112
-
-
15044346433
-
BCR-ABL-transduced human cord blood cells produce abnormal populations in immunodeficient mice
-
Chalandon Y, Jiang X, Christ O, Loutet S, Thanopoulou E, Eaves A et al. BCR-ABL-transduced human cord blood cells produce abnormal populations in immunodeficient mice. Leukemia 2005; 19: 442-448.
-
(2005)
Leukemia
, vol.19
, pp. 442-448
-
-
Chalandon, Y.1
Jiang, X.2
Christ, O.3
Loutet, S.4
Thanopoulou, E.5
Eaves, A.6
-
113
-
-
27144449956
-
SCL/TAL1 expression level regulates human hematopoietic stem cell self-renewal and engraftment
-
Reynaud D, Ravet E, Titeux M, Mazurier F, Renia L, Dubart-Kupperschmitt A et al. SCL/TAL1 expression level regulates human hematopoietic stem cell self-renewal and engraftment. Blood 2005; 106: 2318-2328.
-
(2005)
Blood
, vol.106
, pp. 2318-2328
-
-
Reynaud, D.1
Ravet, E.2
Titeux, M.3
Mazurier, F.4
Renia, L.5
Dubart-Kupperschmitt, A.6
-
114
-
-
38349183668
-
Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia
-
Hong D, Gupta R, Ancliff P, Atzberger A, Brown J, Soneji S et al. Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia. Science 2008; 319: 336-339.
-
(2008)
Science
, vol.319
, pp. 336-339
-
-
Hong, D.1
Gupta, R.2
Ancliff, P.3
Atzberger, A.4
Brown, J.5
Soneji, S.6
-
115
-
-
41249098776
-
Selective inhibition of JAK2-driven erythroid differentiation of polycythemia vera progenitors
-
Geron I, Abrahamsson AE, Barroga CF, Kavalerchik E, Gotlib J, Hood JD et al. Selective inhibition of JAK2-driven erythroid differentiation of polycythemia vera progenitors. Cancer Cell 2008; 13: 321-330.
-
(2008)
Cancer Cell
, vol.13
, pp. 321-330
-
-
Geron, I.1
Abrahamsson, A.E.2
Barroga, C.F.3
Kavalerchik, E.4
Gotlib, J.5
Hood, J.D.6
-
116
-
-
33845355846
-
JAK-2 mutations and their relevance to myeloproliferative disease
-
Levine RL, Gilliland DG. JAK-2 mutations and their relevance to myeloproliferative disease. Curr Opin Hematol 2007; 14: 43-47.
-
(2007)
Curr Opin Hematol
, vol.14
, pp. 43-47
-
-
Levine, R.L.1
Gilliland, D.G.2
-
117
-
-
17044413548
-
The versatile mixed lineage leukaemiagene MLL and its many associations in leukaemogenesis
-
Daser A, Rabbitts TH. The versatile mixed lineage leukaemiagene MLL and its many associations in leukaemogenesis. Semin Cancer Biol 2005; 15: 175-188.
-
(2005)
Semin Cancer Biol
, vol.15
, pp. 175-188
-
-
Daser, A.1
Rabbitts, T.H.2
-
119
-
-
0035228050
-
Distinct classes of human stem cells that differ in proliferative and self-renewal potential
-
Guenechea G, Gan OI, Dorrell C, Dick JE. Distinct classes of human stem cells that differ in proliferative and self-renewal potential. Nat Immunol 2001; 2: 75-82.
-
(2001)
Nat Immunol
, vol.2
, pp. 75-82
-
-
Guenechea, G.1
Gan, O.I.2
Dorrell, C.3
Dick, J.E.4
-
121
-
-
18344410760
-
NOD/SCID/gamma(c)(null) mouse: An excellent recipient mouse model for engraftment of human cells
-
Ito M, Hiramatsu H, Kobayashi K, Suzue K, Kawahata M, Hioki K et al NOD/SCID/gamma(c)(null) mouse: An excellent recipient mouse model for engraftment of human cells. Blood 2002; 100: 3175-3182.
-
(2002)
Blood
, vol.100
, pp. 3175-3182
-
-
Ito, M.1
Hiramatsu, H.2
Kobayashi, K.3
Suzue, K.4
Kawahata, M.5
Hioki, K.6
-
122
-
-
20844434966
-
Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells
-
Shultz LD, Lyons BL, Burzenski LM, Gott B, Chen X, Chaleff S et al Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J Immunol 2005; 174: 6477-6489.
-
(2005)
J Immunol
, vol.174
, pp. 6477-6489
-
-
Shultz, L.D.1
Lyons, B.L.2
Burzenski, L.M.3
Gott, B.4
Chen, X.5
Chaleff, S.6
-
123
-
-
0036644213
-
Functional human T lymphocyte development from cord blood CD34+ cells in nonobese diabetic/Shi-scid, IL-2 receptor gamma null mice
-
Yahata T, Ando K, Nakamura Y, Ueyama Y, Shimamura K, Tamaoki N et al Functional human T lymphocyte development from cord blood CD34+ cells in nonobese diabetic/Shi-scid, IL-2 receptor gamma null mice. J Immunol 2002; 169: 204-209.
-
(2002)
J Immunol
, vol.169
, pp. 204-209
-
-
Yahata, T.1
Ando, K.2
Nakamura, Y.3
Ueyama, Y.4
Shimamura, K.5
Tamaoki, N.6
-
124
-
-
23744474685
-
Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice
-
Ishikawa F, Yasukawa M, Lyons B, Yoshida S, Miyamoto T, Yoshimoto G et al. Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice. Blood 2005; 106 1565-1573.
-
(2005)
Blood
, vol.106
, pp. 1565-1573
-
-
Ishikawa, F.1
Yasukawa, M.2
Lyons, B.3
Yoshida, S.4
Miyamoto, T.5
Yoshimoto, G.6
-
125
-
-
34248547056
-
Human-hemato-lymphoid-system mice: Opportunities and challenges
-
Manz MG. Human-hemato-lymphoid-system mice: Opportunities and challenges. Immunity 2007; 26: 537-541.
-
(2007)
Immunity
, vol.26
, pp. 537-541
-
-
Manz, M.G.1
-
126
-
-
0035885120
-
-
Rossi MI, Medina KL, Garrett K, Kolar G, Comp PC, Shultz LD et al. Relatively normal human lymphopoiesis but rapid turnover of newly formed B cells in transplanted nonobese diabetic/SCID mice. J Immunol 2001; 167: 3033-3042.
-
Rossi MI, Medina KL, Garrett K, Kolar G, Comp PC, Shultz LD et al. Relatively normal human lymphopoiesis but rapid turnover of newly formed B cells in transplanted nonobese diabetic/SCID mice. J Immunol 2001; 167: 3033-3042.
-
-
-
-
127
-
-
1242329864
-
-
Nicolini FE, Cashman JD, Hogge DE, Humphries RK, Eaves CJ. NOD/SCID mice engineered to express human IL-3, GM-CSF and Steel factor constitutively mobilize engrafted human progenitors and compromise human stem cell regeneration. Leukemia 2004; 18: 341-347.
-
Nicolini FE, Cashman JD, Hogge DE, Humphries RK, Eaves CJ. NOD/SCID mice engineered to express human IL-3, GM-CSF and Steel factor constitutively mobilize engrafted human progenitors and compromise human stem cell regeneration. Leukemia 2004; 18: 341-347.
-
-
-
-
128
-
-
0037397929
-
Improved engraftment of human acute myeloid leukemia progenitor cells in beta 2-microglobulin-deficient NOD/SCID mice and in NOD/SCID mice transgenic for human growth factors
-
Feuring-Buske M, Gerhard B, Cashman J, Humphries RK, Eaves CJ, Hogge DE. Improved engraftment of human acute myeloid leukemia progenitor cells in beta 2-microglobulin-deficient NOD/SCID mice and in NOD/SCID mice transgenic for human growth factors. Leukemia 2003; 17: 760-763.
-
(2003)
Leukemia
, vol.17
, pp. 760-763
-
-
Feuring-Buske, M.1
Gerhard, B.2
Cashman, J.3
Humphries, R.K.4
Eaves, C.J.5
Hogge, D.E.6
-
129
-
-
56249100790
-
Environmental factors determine lineage fate in a human model of MLL-AF9 leukemia
-
abstract 3374
-
Wei J, Wunderlich, M, Fox C, DiMartino JF, Mulloy JC. Environmental factors determine lineage fate in a human model of MLL-AF9 leukemia. Blood 2007; 118: P989A (abstract 3374).
-
(2007)
Blood
, vol.118
-
-
Wei, J.1
Wunderlich, M.2
Fox, C.3
DiMartino, J.F.4
Mulloy, J.C.5
-
130
-
-
33344478513
-
Reconstitution of the functional human hematopoietic microenvironment derived from human mesenchymal stem cells in the murine bone marrow compartment
-
Muguruma Y, Yahata T, Miyatake H, Sato T, Uno T, Itoh J et al. Reconstitution of the functional human hematopoietic microenvironment derived from human mesenchymal stem cells in the murine bone marrow compartment. Blood 2006; 107: 1878-1887.
-
(2006)
Blood
, vol.107
, pp. 1878-1887
-
-
Muguruma, Y.1
Yahata, T.2
Miyatake, H.3
Sato, T.4
Uno, T.5
Itoh, J.6
-
131
-
-
18444374992
-
Mesenchymal stem cells promote engraftment of human umbilical cord blood-derived CD34(+) cells in NOD/SCID mice
-
Noort WA, Kruisselbrink AB, in't Anker PS, Kruger M, van Bezooijen RL, de Paus RA et al. Mesenchymal stem cells promote engraftment of human umbilical cord blood-derived CD34(+) cells in NOD/SCID mice. Exp Hematol 2002; 30: 870-878.
-
(2002)
Exp Hematol
, vol.30
, pp. 870-878
-
-
Noort, W.A.1
Kruisselbrink, A.B.2
in't Anker, P.S.3
Kruger, M.4
van Bezooijen, R.L.5
de Paus, R.A.6
-
132
-
-
0141484486
-
-
in 't Anker PS, Noort WA, Kruisselbrink AB, Scherjon SA, Beekhuizen W, Willemze R et al. Nonexpanded primary lung and bone marrow-derived mesenchymal cells promote the engraftment of umbilical cord blood-derived CD34(+) cells in NOD/SCID mice. Exp Hematol 2003; 31: 881-889.
-
in 't Anker PS, Noort WA, Kruisselbrink AB, Scherjon SA, Beekhuizen W, Willemze R et al. Nonexpanded primary lung and bone marrow-derived mesenchymal cells promote the engraftment of umbilical cord blood-derived CD34(+) cells in NOD/SCID mice. Exp Hematol 2003; 31: 881-889.
-
-
-
-
133
-
-
0037562968
-
Cotransplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID mice
-
Angelopoulou M, Novelli E, Grove JE, Rinder HM, Civin C, Cheng L et al. Cotransplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID mice. Exp Hematol 2003; 31: 413-420.
-
(2003)
Exp Hematol
, vol.31
, pp. 413-420
-
-
Angelopoulou, M.1
Novelli, E.2
Grove, J.E.3
Rinder, H.M.4
Civin, C.5
Cheng, L.6
-
134
-
-
46149111699
-
Effect of mesenchymal stem cell transplantation on the engraftment of human hematopoietic stem cells and leukemic cells in mice model
-
Lee ST, Maeng H, Chwae YJ, Oh DJ, Kim YM, Yang WI. Effect of mesenchymal stem cell transplantation on the engraftment of human hematopoietic stem cells and leukemic cells in mice model. Int J Hematol 2008; 87 327-337.
-
(2008)
Int J Hematol
, vol.87
, pp. 327-337
-
-
Lee, S.T.1
Maeng, H.2
Chwae, Y.J.3
Oh, D.J.4
Kim, Y.M.5
Yang, W.I.6
|