Five-coordinated oxovanadium(IV) complexes derived from amino acids and ciprofloxacin: Synthesis, spectral, antimicrobial, and DNA interaction approach

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 24, 2008, Pages 6494-6500

  Patel, M N ^a   Patel, S H ^a   Chhasatia, M R ^a   Parmar, P A ^a  

^a SARDAR PATEL UNIVERSITY   (India)

Author keywords

Ciprofloxacin; DNA intercalation; Gel electrophoresis; Oxovanadium; SOD like activity; Viscometric studies

Indexed keywords

CIPROFLOXACIN; DNA; ENROFLOXACIN; GATIFLOXACIN; LEVOFLOXACIN; METAL COMPLEX; NORFLOXACIN; OFLOXACIN; OXOVANADIUM CIPROFLOXACIN COMPLEX; OXOVANADIUM DERIVATIVE; PEFLOXACIN; SPARFLOXACIN; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; VANADIUM DERIVATIVE;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; COMPLEX FORMATION; DRUG DNA INTERACTION; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; GEL ELECTROPHORESIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PSEUDOMONAS AERUGINOSA; REACTION ANALYSIS; SERRATIA MARCESCENS; STAPHYLOCOCCUS AUREUS; VISCOMETRY;

ANTI-INFECTIVE AGENTS; BACILLUS SUBTILIS; CHEMISTRY, PHARMACEUTICAL; CIPROFLOXACIN; DNA; ESCHERICHIA COLI; LIGANDS; MASS SPECTROMETRY; METALS; MODELS, CHEMICAL; PSEUDOMONAS AERUGINOSA; SERRATIA MARCESCENS; STAPHYLOCOCCUS AUREUS; THERMOGRAVIMETRY; VANADATES;

ESCHERICHIA COLI; PSEUDOMONAS AERUGINOSA; SERRATIA MARCESCENS; STAPHYLOCOCCUS AUREUS;

EID: 56249096166     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.10.068     Document Type: Article

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28. 2O (0.6327 g, 5 mM) was added to an ethanolic solution of (50 mL). dl-alanine (L1) (0.2227 g, 5 mM), followed by accumulation of formerly primed solution of (Cip·HCl) (0.917 g, 5 mM) in water and pH of the reaction mixture was adjusted to 6.0-7.0 pH with dilute NaOH solution. The resulting green solution was refluxed with stirring for 7 h, and then heated on steam bath to evaporate up to half volume. The reaction mixture was kept for overnight at room temperature. A fine green color product was obtained. The obtained product was washed with ether and dried over vacuum desiccators. The compounds II-V were prepared according to the same method and their physicochemical parameters are summarized in Table 8.