Mucoadhesive microdiscs engineered for ophthalmic drug delivery: Effect of particle geometry and formulation on preocular residence time

Investigative Ophthalmology and Visual Science

Volumn 49, Issue 11, 2008, Pages 4808-4815

  Choy, Young Bin ^a   Park, Jung Hwan ^b   McCarey, Bernard E ^c   Edelhauser, Henry F ^c   Prausnitz, Mark R ^a  

^a Georgia Institute of Technology   (United States)

^b Gachon University College of Medicine   (South Korea)

^c EMORY EYE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG VEHICLE; MACROGOL; MICROSPHERE; MUCOADHESIVE MICRODISC; POLYGLACTIN; UNCLASSIFIED DRUG; BIOMATERIAL; DRUG CARRIER; LACTIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID POLYGLYCOLIC ACID COPOLYMER; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DISSOLUTION; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG RETENTION; EMULSION; EYELID REFLEX; FLUORESCENCE IMAGING; GEOMETRY; IN VITRO STUDY; IN VIVO CULTURE; MALE; MUCOADHESION; NONHUMAN; PRIORITY JOURNAL; RABBIT; SHEAR STRESS; SURFACE PROPERTY; SUSPENSION; TABLET; ADHESION; ANIMAL; COMPARATIVE STUDY; CONJUNCTIVA; DRUG EFFECT; ELECTRONICS; EQUIPMENT DESIGN; EYE DISEASE; FLUORESCENCE MICROSCOPY; HUMAN; INSTRUMENTATION; SCANNING ELECTRON MICROSCOPY; TOPICAL DRUG ADMINISTRATION; ULTRASTRUCTURE;

ADHESIVENESS; ADMINISTRATION, TOPICAL; ANIMALS; BIOCOMPATIBLE MATERIALS; CONJUNCTIVA; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; EQUIPMENT DESIGN; EYE DISEASES; HUMANS; LACTIC ACID; MALE; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, FLUORESCENCE; MINIATURIZATION; POLYGLYCOLIC ACID; RABBITS; SURFACE PROPERTIES;

EID: 56149126515     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-2515     Document Type: Article

References (40)

1. Ghate D, Edelhauser HF. Ocular drug delivery. Expert Opin Drug Deliv. 2006;3:275-287.
2. Sultana Y, Jain R, Aqil M, Ali A. Review of ocular drug delivery. Curr Drug Del. 2006;3:207-217.
3. Saettone MF, Giannaccini B, Ravecca S, Marca FL, Tota G. Polymer effects on ocular bioavailability - the influence of different liquid vehicles on the mydriatic response of tropicamide in humans and rabbits. Int J Pharm. 1984;20:187-202. (Pubitemid 14091719)
4. Saettone MF, Giannaccini B, Guiducci A, Marca F, Tota G. Polymer effects on ocular bioavailability, II: the influence of benzalkonium chloride on the mydriatic response of tropicamide in different polymeric vehicles. Int J Pharm. 1985;25:73-83.
5. Chang SC, Chien DS, Budgaard H, Lee VHL. Relative effectiveness of prodrug and viscous approaches in maximizing the ratio of ocular to systemic absorption of topically applied timolol. Exp Eye Res. 1988;46:56-69.
6. Roziere A, Mazuel C, Grove J, Plazonnet B. Gelrite: a novel ion activated, in situ gelling polymer for ophthalmic vehicles: effect on bioavailability of timolol. Int J Pharm. 1989;57:163-168. (Pubitemid 20011840)
7. Miller SC, Donovan MD. Effect of poloxamer 407 gel on the miotic activity of pilocarpine nitrate in rabbits. Int J Pharm. 1982;12:147-152.
8. Macoul KL, Pavan-Langston D. Pilocarpine ocusert system for sustained control of ocular hypertension. Arch Ophthalmol. 1975;93:587-590.
9. Varde NK, Pack DW. Microspheres for controlled release drug delivery. Expert Opin Biol Ther. 2004;4:35-51. (Pubitemid 38057265)
10. Loftsson T, Hreinsdottir D, Stefansson E. Cyclodextrin microparticles for drug delivery to the posterior segment of the eye: aqueous dexamethasone eyedrops. J Pharm Pharmacol. 2007;59:629-635. (Pubitemid 47051105)
11. Gavini E, Chetoni P, Cossu M, Alvarez MG, Saettone MF, Giunchedi P. PLGA microspheres for the ocular delivery of a peptide drug, vancomycin using emulsification/spray-drying as the preparation method: in vitro/in vivo studies. Eur J Pharm Biopharm. 2004;57:207-212. (Pubitemid 38283696)
12. Vasir JK, Tambwekar K, Garg S. Bioadhesive microspheres as a controlled drug delivery system. Int J Pharm. 2003;255:13-32. (Pubitemid 36369587)
13. Ludwig A. The use of mucoadhesive polymers in ocular drug delivery. Adv Drug Del Rev. 2005;57:1595-1639. (Pubitemid 41443472)
14. Genta I, Conti B, Perugini P, Pavanetto F, Spadaro A, Puglisi G. Bioadhesive microspheres for ophthalmic administration of acyclovir. J Pharm Pharmacol. 1997;49:737-742. (Pubitemid 27386891)
15. Durrani AM, Farr SJ, Kellaway IW. Precorneal clearance of mucoadhesive microspheres from the rabbit eye. J Pharm Pharmacol. 1995;47:581-584.
16. Giunchedi P, Conte U, Chetoni P, Saettone MF. Pectin microspheres as ophthalmic carriers for piroxicam: evaluation in vitro and in vivo in albino rabbits. Eur J Pharm Sci. 1999;9:1-7. (Pubitemid 29430186)
17. Zimmer AK, Chetoni P, Saettone MF, Zerbe H, Kreuter J. Evaluation of pilocarpine-loaded albumin particles as controlled drug delivery systems for the eye, II: co-administration with bioadhesive and viscous polymers. J Control Rel. 1995;33:31-46.
18. Iwanaga K, Ono S, Narioka K, et al. Application of surface-coated liposomes for oral delivery of peptide: effects of coating the liposome's surface on the GI transit of insulin. J Pharm Sci. 1999;88:248-252. (Pubitemid 29084739)
19. Efremova NV, Huang Y, Peppas NA, Leckband DE. Direct measurement of interactions between tethered poly(ethylene glycol) chains and adsorbed mucin layers. Langmuir. 2002;18:836-845. (Pubitemid 35384118)
20. Shive MS, Anderson JM. Biodegradation and biocompatibility of PLA and PLGA microspheres. Adv Drug Del Rev. 1997;28:5-24.
21. Zalipsky S. Chemistry of polyethylene glycol conjugates with biologically active molecules. Adv Drug Del Rev. 1995;16:157-182.
22. Champion JA, Katare YK, Mitragotri S. Particle shape: a new design parameter for micro- and nanoscale drug delivery carriers. J Control Release. 2007;121:3-9. (Pubitemid 47126059)
23. Reader MJ. Influence of isotonic agents on the stability of thimerosal in ophthalmic formulations. J Pharm Sci. 1984;73:840-841.
24. Berkland C, Kim K, Pack DW. PLG microsphere size controls drug release rate through several competing factors. Pharm Res. 2003;20:1055-1062. (Pubitemid 36774277)
25. Dilly PN. Structure and function of the tear film. In: Sullivan DA, ed. Lacrimal Gland, Tear Film, and Dry Eye Syndromes. New York: Plenum Press; 1994.
26. Eckhoff RK. A static investigation of the Coulter principle of particle sizing. J Sci Instrum. 1969;2:973-977.
27. Forcino RG, Jonnalagadda S. The effect of fabrication methods on the mechanical and thermal properties of poly(lactide-co-glycolide) scaffolds. J Appl Polym Sci. 2007;104:944-949. (Pubitemid 46492517)
28. Owens H, Philips J. Spreading of the tears after a blink. Cornea. 2001;20:484-487.
29. Sieg JW, Triplett JW. Precorneal retention of topical instilled micronized particles. J Pharm Sci. 1980;69:863-864.
30. Zhu H, Chauhan A. A mathematical model for ocular tear and solute balance. Curr Eye Res. 2005;30:841-854. (Pubitemid 43154702)
31. Watsky MA, Jablonski MM, Edelhauser HF. Comparison of conjunctival and corneal surface areas in rabbit and human. Curr Eye Res. 1988;7:483-486.
32. Schoenwald RW. Ocular pharmacokinetics. In: Zimmerman TJ, ed. Textbook of Ocular Pharmacology. Philadelphia: Lippincott-Raven Publishers; 1997:119-138.
33. Lu L, Stamatas GN, Mikos AG. Controlled release of transforming growth factor beta-1 from biodegradable polymer microparticles. J Biomed Mater Res Part A. 2000;50:440-451. (Pubitemid 30180737)
34. Cleek RL, Ting KC, Eskin SG, Mikos AG. Microparticles of poly(DL-lactic-co-glycolic acid)/poly(ethylene glycol) blends for controlled drug delivery. J Control Release. 1997;48:259-268. (Pubitemid 27401983)
35. Yeh M-K, Jenkins PG, Davis SS, Coombes AGA. Improving the delivery capacity of microparticle systems using blends of poly(DL-lactide co-glycolide) and poly(ethylene glycol). J Control Release. 1995;37:1-9.
36. Khan MZ, Prebeg Z, Kurjakovic N. A pH-dependent colon targeted oral drug delivery system using methacrylic acid copolymers, I: manipulation of drug release using Eudragit L100-55 and Eudragit S100 combinations. J Control Release. 1999;58:215-222. (Pubitemid 29112892)
37. De Campos AM, Sanchez A, Gref R, Calvo P, Alonso MJ. The effect of a PEG versus a chitosan coating on the interaction of drug colloidal carriers with the ocular mucosa. Eur J Pharm Sci. 2003;20:73-81. (Pubitemid 37103234)
38. Giannavola C, Bucolo C, Maltese A, et al. Influence of preparation conditions on acyclovir-loaded poly-d,l-lactic acid nanospheres and effect of PEG coating on ocular drug bioavailability. Pharm Res. 2003;20:584-590. (Pubitemid 36438901)
39. Kompella UB, Sundaram S, Raghava S, Escobar ER. Luteinizing hormone-releasing hormone agonist and transferrin functionalizations enhance nanoparticle delivery in a novel bovine ex vivo eye model. Mol Vis. 2006;12:1185-1198. (Pubitemid 44637858)
40. Saettone MF, Salminen L. Ocular inserts for topical delivery. Adv Drug Deliv Rev. 1995;16:95-106.