CD20+ T-cell Lymphoma: Clinicopathologic analysis of 9 cases and a review of the literature

American Journal of Surgical Pathology

Volumn 32, Issue 11, 2008, Pages 1593-1607

  Rahemtullah, Aliyah ^a,b,c   Longtine, Janina A ^c,d   Harris, Nancy Lee ^a,b,c   Dorn, Michelle ^a,b,c   Zembowicz, Artur ^a,b,c   Quintanilla Fend, Leticia ^e   Preffer, Frederic I ^a,b,c   Ferry, Judith A ^a,b,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Department of Pathology ^*

^c HARVARD MEDICAL SCHOOL   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

CD20; CD30; Enteropathy; Epstein Barr virus; Mycosis fungoides; Rituximab; T cell lymphoma

Indexed keywords

ANTHRACYCLINE; CD20 ANTIGEN; CORTICOSTEROID DERIVATIVE; RITUXIMAB; ANTINEOPLASTIC AGENT;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; B CELL LYMPHOMA; CANCER CHEMOTHERAPY; CANCER CLASSIFICATION; CANCER RADIOTHERAPY; CANCER SURVIVAL; CELL STRUCTURE; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; ENTEROPATHY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOPHENOTYPING; LYMPHOCYTE SUBPOPULATION; MALE; MOLECULAR GENETICS; MYCOSIS FUNGOIDES; T CELL LYMPHOMA; BIOSYNTHESIS; FLOW CYTOMETRY; GENETICS; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; IN SITU HYBRIDIZATION; MULTIMODALITY CANCER THERAPY; PATHOLOGY; PHOTOTHERAPY; POLYMERASE CHAIN REACTION; RADIOTHERAPY; SOUTHERN BLOTTING; T LYMPHOCYTE RECEPTOR GENE;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD20; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BLOTTING, SOUTHERN; COMBINED MODALITY THERAPY; FEMALE; FLOW CYTOMETRY; GENES, T-CELL RECEPTOR BETA; GENES, T-CELL RECEPTOR GAMMA; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; IN SITU HYBRIDIZATION; LYMPHOMA, T-CELL; MALE; PHOTOTHERAPY; POLYMERASE CHAIN REACTION; RADIOTHERAPY;

EID: 56149125371     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e31817d7452     Document Type: Article

References (48)

1. Algino KM, Thomason RW, King DE, et al. CD20 (pan-B cell antigen) expression on bone marrow-derived T cells. Am J Clin Pathol. 1996;106:78-81.
2. Blakolmer K, Vesely M, Kummer JA, et al. Immunoreactivity of B-cell markers (CD79a, L26) in rare cases of extranodal cytotoxic peripheral T- (NK/T-) cell lymphomas. Mod Pathol. 2000;13: 766-772.
3. Buckner CL, Christiansen LR, Bourgeois D, et al. CD20 positive T-cell lymphoma/leukemia: a rare entity with potential diagnostic pitfalls. Ann Clin Lab Sci. 2007;37:263-267.
4. Diamandidou E, Colome-Grimmer M, Fayad L, et al. Transformation of mycosis fungoides/Sezary syndrome: clinical characteristics and prognosis. Blood. 1998;92:1150-1159.
5. Echeverri C, Fisher S, King D, et al. Immunophenotypic variability of B-cell non-Hodgkin lymphoma: a retrospective study of cases analyzed by flow cytometry. Am J Clin Pathol. 2002;117: 615-620.
6. Foon KA, Schroff RW, Gale RP. Surface markers on leukemia and lymphoma cells: recent advances. Blood. 1982;60:1-19.
7. Gallamini A, Stelitano C, Calvi R, et al. Peripheral T-cell lymphoma unspecified (PTCL-U): a new prognostic model from a retrospective multicentric clinical study. Blood. 2004;103:2474-2479.
8. Garcia MJ, Martinez-Delgado B, Granizo JJ, et al. IgH, TCR-gamma, and TCR-beta gene rearrangement in 80 B- and T-cell non-Hodgkin's lymphomas: study of the association between proliferation and the so-called "aberrant" patterns. Diagn Mol Pathol. 2001;10:69-77.
9. Gisselbrecht C, Gaulard P, Lepage E, et al. Prognostic significance of T-cell phenotype in aggressive non-Hodgkin's lymphomas. Groupe d'Etudes des Lymphomes de l'Adulte (GELA). Blood. 1998;92:76-82.
10. Gonin J, Kadiri H, Bensaci S, et al. Primary mediastinal anaplastic ALK-1-positive large-cell lymphoma of T/NK-cell type expressing CD20. Virchows Arch. 2007;450:355-358.
11. Hamilton-Dutoit SJ, Pallesen G. B cell associated monoclonal antibody L26 may occasionally label T cell lymphomas. APMIS. 1989;97:1033-1036.
12. Hultin LE, Hausner MA, Hultin PM, et al. CD20 (pan-B cell) antigen is expressed at a low level on a subpopulation of human T lymphocytes. Cytometry. 1993;14:196-204.
13. Jaffe ES, Harris NL, Stein H, et al. World Health Organization Classification of Tumours. Pathology and Genetics. Tumours of the Haematopoietic and Lymphoid Tissues. Lyon, France: IARC Press; 2001:115-117, 191-235.
14. Kanzaki M, Shibata H, Mogami H, et al. Expression of calciumpermeable cation channel CD20 accelerates progression through the G1 phase in Balb/c 3T3 cells. J Biol Chem. 1995;270: 13099-13104.
15. Kitamura A, Yamashita Y, Mori N. CD20-positive cytotoxic T-cell lymphoma: report of two cases and review of the literature. J Clin Exp Hematop. 2005;45:45-50.
16. Linder J, Ye Y, Armitage JO, et al. Monoclonal antibodies marking B-cell non-Hodgkin's lymphoma in paraffin-embedded tissue. Mod Pathol. 1988;1:29-34.
17. Magro CM, Seilstad KH, Porcu P, et al. Primary CD20+CD10+CD8+ T-cell lymphoma of the skin with IgH and TCR beta gene rearrangement. Am J Clin Pathol. 2006;126:14-22.
18. Mason DY, Comans-Bitter WM, Cordell JL, et al. Antibody L26 recognizes an intracellular epitope on the B-cell-associated CD20 antigen. Am J Pathol. 1990;136:1215-1222.
19. Meleshko AN, Belevtsev MV, Savitskaja TV, et al. The incidence of T-cell receptor gene rearrangements in childhood B-lineage acute lymphoblastic leukemia is related to immunophenotype and fusion oncogene expression. Leuk Res. 2006;30:795-800.
20. Mohrmann RL, Arber DA. CD20-positive peripheral T-cell lymphoma: report of a case after nodular sclerosis Hodgkin's disease and review of the literature. Mod Pathol. 2000;13: 1244-1252.
21. Moreau I, Duvert V, Banchereau J, et al. Culture of human fetal B-cell precursors on bone marrow stroma maintains highly proliferative CD20dim cells. Blood. 1993;81:1170-1178.
22. Murayama Y, Mukai R, Sata T, et al. Transient expression of CD20 antigen (pan B cell marker) in activated lymph node T cells. Microbiol Immunol. 1996;40:467-471.
23. Norton AJ, Isaacson PG. Monoclonal antibody L26: an antibody that is reactive with normal and neoplastic B lymphocytes in routinely fixed and paraffin wax embedded tissues. J Clin Pathol. 1987;40:1405-1412.
24. Pawson R, Richardson DS, Pagliuca A, et al. Adult T-cell leukemia/ lymphoma in London: clinical experience of 21 cases. Leuk Lymphoma. 1998;31:177-185.
25. Polyak MJ, Ayer LM, Szczepek AJ, et al. A cholesterol-dependent CD20 epitope detected by the FMC7 antibody. Leukemia. 2003;17:1384-1389.
26. Quintanilla-Martinez L, Preffer F, Rubin D, et al. CD20+ T-cell lymphoma. Neoplastic transformation of a normal T-cell subset. Am J Clin Pathol. 1994;102:483-489.
27. Quintanilla-Martinez L, Fend F, Moguel LR, et al. Peripheral T-cell lymphoma with Reed-Sternberg-like cells of B-cell phenotype and genotype associated with Epstein-Barr virus infection. Am J Surg Pathol. 1999;23:1233-1240.
28. Ramsay AD, Smith WJ, Earl HM, et al. T-cell lymphomas in adults: a clinicopathological study of eighteen cases. J Pathol. 1987; 152:63-76.
29. Reiser M, Josting A, Soltani M, et al. T-cell non-Hodgkin's lymphoma in adults: clinicopathological characteristics, response to treatment and prognostic factors. Leuk Lymphoma. 2002; 43:805-811.
30. Rudiger T, Ichinohasama R, Ott MM, et al. Peripheral T-cell lymphoma with distinct perifollicular growth pattern: a distinct subtype of T-cell lymphoma? Am J Surg Pathol. 2000;24: 117-122.
31. Seliem RM, Freeman JK, Steingart RH, et al. Immunophenotypic changes and clinical outcome in B-cell lymphomas treated with rituximab. Appl Immunohistochem Mol Morphol. 2006;14: 18-23.
32. Sen F, Kang S, Cangiarella J, et al. CD20 positive mycosis fungoides: a case report. J Cutan Pathol. 2008;35:398-403.
33. Serke S, Schwaner I, Yordanova M, et al. Monoclonal antibody FMC7 detects a conformational epitope on the CD20 molecule: evidence from phenotyping after Rituxan therapy and transfectant cell analyses. Cytometry. 2001;46:98-104.
34. Storie I, Wilson GA, Granger V, et al. Circulating CD20dim T-lymphocytes increase with age: evidence for a memory cytotoxic phenotype. Clin Lab Haematol. 1995;17:323-328.
35. Sun T, Akalin A, Rodacker M, et al. CD20 positive T cell lymphoma: is it a real entity? J Clin Pathol. 2004;57:442-444.
36. Takami A, Saito M, Nakao S, et al. CD20-positive T-cell chronic lymphocytic leukaemia. Br J Haematol. 1998;102: 1327-1329.
37. Tamayose K, Sato N, Ando J, et al. CD3-negative, CD20-positive T-cell prolymphocytic leukemia: case report and review of the literature. Am J Hematol. 2002;71:331-335.
38. Tarkowski M. Expression and a role of CD30 in regulation of T-cell activity. Curr Opin Hematol. 2003;10:267-271.
39. Tedder TF, Klejman G, Schlossman SF, et al. Structure of the gene encoding the human B lymphocyte differentiation antigen CD20 (B1). J Immunol. 1989;142:2560-2568.
40. Tzankov AS, Went PT, Munst S, et al. Rare expression of BSAP (PAX-5) in mature T-cell lymphomas. Mod Pathol. 2007; 20:632-637.
41. Uherova P, Ross CW, Finn WG, et al. Peripheral T-cell lymphoma mimicking marginal zone B-cell lymphoma. Mod Pathol. 2002;15: 420-425.
42. van Dongen JJ, Langerak AW, Bruggemann M, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia. 2003;17:2257-2317.
43. Warzynski MJ, Graham DM, Axtell RA, et al. Low level CD20 expression on T cell malignancies. Cytometry. 1994;18:88-92.
44. Weiss LM, Picker LJ, Grogan TM, et al. Absence of clonal beta and gamma T-cell receptor gene rearrangements in a subset of peripheral T-cell lymphomas. Am J Pathol. 1988;130:436-442.
45. Yao X, Teruya-Feldstein J, Raffeld M, et al. Peripheral T-cell lymphoma with aberrant expression of CD79a and CD20: a diagnostic pitfall. Mod Pathol. 2001;14:105-110.
46. Yasukawa M, Arai J, Kakimoto M, et al. CD20-positive adult T-cell leukemia. Am J Hematol. 2001;66:39-41.
47. Yokose N, Ogata K, Sugisaki Y, et al. CD20-positive T cell leukemia/lymphoma: case report and review of the literature. Ann Hematol. 2001;80:372-375.
48. Zettl A, Lee SS, Rudiger T, et al. Epstein-Barr virus-associated B-cell lymphoproliferative disorders in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, unspecified. Am J Clin Pathol. 2002;117:368-379.