Is larval (Maggot) debridement effective for removal of necrotic tissue from chronic wounds?

Journal of Wound, Ostomy and Continence Nursing

Volumn 35, Issue 4, 2008, Pages 378-384

  Gray, Mikel ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; ARTICLE; CHRONIC DISEASE; DEBRIDEMENT; HUMAN; INJURY; LARVA; METHODOLOGY; NECROSIS; WOUND HEALING;

ANIMALS; CHRONIC DISEASE; DEBRIDEMENT; HUMANS; LARVA; NECROSIS; WOUND HEALING; WOUNDS AND INJURIES;

EID: 56149110609     PISSN: 10715754     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.WON.0000326655.50316.0e     Document Type: Article

References (30)

1. Dorland's Illustrated Medical Dictionary. 31st ed. Philadelphia: Saunders; 2007:481.
2. Saap LJ, Falanga V. Debridement performance index and its correlation with complete closure of diabetic foot ulcers. Wound Repair Regen. 2002;10(6):354-359.
3. Kirshen C, Woo K, Ayella EA, SIbbald RG. Debridement: a vital component of wound bed preparation. Adv Skin Wound Care. 2006;19(9):506-517.
4. Schultz G, Mozingo D, Romanelli M, Claxton K. Wound healing and TIME; new concepts and scientific applications. Wound Repair Regen. 2005;13(4)(suppl):S1- S11.
5. Ayello EA, Cuddigan JE. Debridement: controlling the necrotic/cellular burden. Adv Skin Wound Care. 2004;17(2): 66-75.
6. Whitaker IS, Twine C, Whitaker MJ, Welck M, Brown CS, Shandall A. Larval therapy from antiquity to the present day: mechanisms of action, clinical applications and future potential. Postgrad Med J. 2007;83(980):409-413.
7. Blake FAS, Abromeit B, Bubenheim M, Li L, Schmelze R. The biosurgical wound debridement: experimental investigation of efficiency and practicability. Wound Repair Regen. 2007;15:756-761.
8. Fleischmann W, Russ MK, Moch D. Surgical wound treatment. Chirurg. 1998;69(2):W222-W232.
9. Parnes A, Lagan KM. Larval therapy in wound management: a review. Int J Clin Pract. 2007;61(3):488-493.
10. Casu RE, Pearson RD, Jarmey JM, Cadogan LC, Riding GA, Tellam RL. Excretory/secretory chymotrypsin from Lucilia cuprina: purification, enzymatic specificity and amino acid sequence deduced from mRNA. Insect Mol Biol. 1994;3(4): 201-211.
11. Casu RE, Jarmey JM, Elvin CM, Eisemann CH. Isolation of a trypsin-like serine protease gene family from the sheep blowfly Lucilia cuprina. Insect Mol Biol. 1994;3(3):159-170.
12. Sherman RA. Maggot therapy for treating diabetic foot ulcers unresponsive to conventional therapy. Diabetes Care. 2003; 26(2):446-451.
13. Armstrong DG, Salas P, Short B, et al. Maggot therapy in "lower-extremity hospice" wound care: fewer amputations and more antibiotic-free days. J Am Podiatr Med Assoc. 2005; 95(3):254-257.
14. Sherman RA. Maggot versus conservative debridement therapy for the treatment of pressure ulcers. Wound Repair Regen. 2002;10:208-214.
15. Wayman J, Nirojogi V, Walker A, Sowinski A, Walker M. The cost effectiveness of larval therapy in venous ulcers. J Tissue Viability. 2000;10(3):91-94.
16. Raynor P, Dumville J, Cullum N. A new clinical trial of the effect of larval therapy. J Tissue Viability. 2004;14(3): 104-105.
17. VenUS II Larval Therapy Study. https://www.hsytu.york.ac.uk/venusii/. Accessed April 24, 2008.
18. Sherman RA, Shimoda KJ. Presurgical maggot debridement of soft tissue wound is associated with decreased rates of postoperative infection. Clin Infect Dis. 2004;39(1):1067-1670.
19. Tantawi TI, Gohar YM, Kotb MM, Beshara FM, El-Naggar MM. Clinical and microbiological efficacy of MDT in the treatment of diabetic foot ulcers. J Wound Care. 2007;16(9): 379-383.
20. Steenvoorde P, Budding T, Osham J. Determining pain levels in patients treated with maggot debridement therapy. J Wound Care. 2005;14(10):485-488.
21. Courtenay M, Church JCT, Ryan TJ. Larva therapy in wound management. J R Soc Med. 2000;93:72-74.
22. Wolff H, Hansson C. Larval therapy-an effective method for ulcer debridement. Clin Dermatol. 2003;28:134-137.
23. Kitching M. Patients' perceptions and experiences of larval therapy. J Wound Care. 2004;13(1):25-29.
24. Tanyuksel M, Araz E, Dundar K, et al. Maggot debridement therapy in the treatment of chronic wounds in a military hospital setup in Turkey. Dermatology. 2005;210(2):115-118.
25. Steenvoorde P, Oskam J. Bleeding complications in patients treated with maggot debridement therapy. Lower Extremity Wounds. 2005;4(1):57-58.
26. Steenvoorde P, van Doorn LP. Maggot debridement therapy: serious bleeding can occur. Report of a case. J Wound Ostomy Continence Nurs. 2008;35(4):412-414.
27. Steenvoorde P, Jacobi CE, van Doorn LP, Oskam J. Maggot debridement therapy of infected ulcers: patient and wound factors influencing outcome. Ann R Coll Surg Eng. 2007;89:596-602.
28. Monarch Labs Web page. http://www.monarchlabs.com/ pr.htm. Accessed April 24, 2008.
29. Petherick ES, O'Meara S, Spilsbury K, Iglesias CP, Nelson EA, Togerson DJ. Patient acceptability of larval therapy for leg ulcer treatment: a randomized survey to inform the sample size calculation of a randomized trial. BMC Med Res Methodol. 2006;6:43-46.
30. Van Veen LJ. Maggot debridement therapy: a case study. J Wound Ostomy Continence Nurs. 2008;35(4):432-436.