Scleral hydraulic conductivity and macromolecular diffusion in patients with uveal effusion syndrome

Investigative Ophthalmology and Visual Science

Volumn 49, Issue 11, 2008, Pages 5033-5040

  Jackson, Timothy L ^a,b   Hussain, Ali ^b   Morley, Ana M S ^b,c   Sullivan, Paul M ^c   Hodgetts, Andrea ^b   El Osta, Austen ^b   Hillenkamp, Jost ^b,d   Charles, Stephen J ^e   Sheard, Richard ^f   Williamson, Tom H ^b   Kumar, Anupma ^b   Laidlaw, D Alistair H ^b   Woon, W Hong ^g   Costen, Mark J ^h   Luff, Andrew J ^h   Marshall, John ^b  

^a KING S COLLEGE HOSPITAL   (United Kingdom)

^b ST THOMAS HOSPITAL   (United Kingdom)

^c MOORFIELDS EYE HOSPITAL   (United Kingdom)

^d UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^e MANCHESTER ROYAL EYE HOSPITAL   (United Kingdom)

^f ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

^g LEEDS GENERAL INFIRMARY   (United Kingdom)

^h SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; COLLAGEN FIBRIL; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; DEXTRAN; DIAGNOSTIC AGENT; DRUG DERIVATIVE; FLUORESCEIN ISOTHIOCYANATE; WATER;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROL GROUP; CONTROLLED STUDY; DATA ANALYSIS; DIFFUSION COEFFICIENT; FEMALE; FLUID RETENTION; HUMAN; HUMAN TISSUE; HYDRAULIC CONDUCTIVITY; INTRAOCULAR PRESSURE; MALE; PREOPERATIVE PERIOD; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUESTIONNAIRE; RETINA DETACHMENT; SCLERA; SPECTROPHOTOMETER; UVEA DISEASE; UVEAL EFFUSION SYNDROME; VISUAL ACUITY; WATER FLOW; CLINICAL TRIAL; COMPARATIVE STUDY; EXUDATE; EYE SURGERY; FOLLOW UP; METABOLISM; METHODOLOGY; MIDDLE AGED; MULTICENTER STUDY; OSMOLARITY; PATHOLOGY; PATHOPHYSIOLOGY; PROGNOSIS; SYNDROME; TIME; TRANSPORT AT THE CELLULAR LEVEL;

ADULT; AGED; BIOLOGICAL TRANSPORT; DEXTRANS; EXUDATES AND TRANSUDATES; FEMALE; FLUORESCEIN-5-ISOTHIOCYANATE; FOLLOW-UP STUDIES; HUMANS; INTRAOCULAR PRESSURE; MALE; MIDDLE AGED; OPHTHALMOLOGIC SURGICAL PROCEDURES; OSMOLAR CONCENTRATION; PROGNOSIS; PROSPECTIVE STUDIES; SCLERA; SYNDROME; TIME FACTORS; UVEAL DISEASES; WATER;

EID: 56149097635     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-1980     Document Type: Article

References (21)

1. Uyama M, Takahashi K, Kozaki J, et al. Uveal effusion syndrome: clinical features, surgical treatment, histologic examination of the sclera, and pathophysiology. Ophthalmology. 2000;107:441-449. (Pubitemid 30191363)
2. Forrester JV, Lee WR, Kerr PR, Dua HS. The uveal effusion syndrome and trans-scleral flow. Eye. 1990;4:354-365. (Pubitemid 20307093)
3. Ward RC, Gragoudas ES, Pon DM, Albert DM. Abnormal scleral findings in uveal effusion syndrome. Am J Ophthalmol. 1988;106:139-146. (Pubitemid 18190826)
4. Brockhurst RJ. Vortex vein decompression for nanophthalmic uveal effusion. Arch Ophthalmol. 1980;98:1987-1990.
5. Johnson MW, Gass JD. Surgical management of the idiopathic uveal effusion syndrome. Ophthalmology. 1990;97:778-785. (Pubitemid 20183281)
6. Gass JD. Uveal effusion syndrome: a new hypothesis concerning pathogenesis and technique of surgical treatment. Trans Am Ophthalmol Soc. 1983;81:246-260. (Pubitemid 14111600)
7. Jackson TL, Hussain A, Hodgetts A, et al. Human scleral hydraulic conductivity: age-related changes, topographical variation, and potential scleral outflow facility. Invest Ophthalmol Vis Sci. 2006;47:4942-4946. (Pubitemid 46586397)
8. Olsen TW, Aaberg SY, Geroski DH, Edelhauser HF. Human sclera: thickness and surface area. Am J Ophthalmol. 1998;125:237-241.
9. Levick JR. Flow through interstitium and other fibrous matrices. Q J Exp Physiol. 1987;72:409-437.
10. Jackson TL, Antcliff RJ, Hillenkamp J, Marshall J. Human retinal molecular weight exclusion limit and estimate of species variation. Invest Ophthalmol Vis Sci. 2003;44:2141-2146. (Pubitemid 36520310)
11. Amaral J, Fariss RN, Campos MM, et al. Transscleral-RPE permeability of PEDF and ovalbumin proteins: implications for subconjunctival protein delivery. Invest Ophthalmol Vis Sci. 2005;46:4383-4392. (Pubitemid 44264530)
12. Boubriak OA, Urban JPG, Bron AJ. Differential effects of aging on transport properties of anterior and posterior human sclera. Exp Eye Res. 2003;76:701-713.
13. Bill A, Wahlinder PE. The aqueous effects of pilocarpine on the dynamics of aqeous humor in a primate (Macaca irus). Invest Ophthalmol. 1966;5:170-175.
14. Kelly DE, Hageman GS, McGregar JA. Uveal compartmentalization in the hamster eye revealed by fine structural and tracer studies: Implications for uveoscleral outflow. Invest Ophthalmol Vis Sci. 1983;24:1288-1304.
15. Emi K, Pederson JE, Toris CB. Hydrostatic pressure of the suprachoroidal space. Invest Ophthalmol Vis Sci. 1989;30:233-238.
16. Boubriak OA, Urban JP, Akhtar S, et al. The effect of hydration and matrix composition on solute diffusion in rabbit sclera. Exp Eye Res. 2000;71:503-514. (Pubitemid 30947623)
17. Bill A. The drainage of albumin from the uvea. Exp Eye Res. 1964;3:179-187.
18. Alm A. Ocular circulation. In: Hart WM, ed. Adler's Physiology of the Eye. 9th ed. London: Mosby; 1992;Chap. 6.
19. Ambati J, Canakis CS, Miller JW, et al. Diffusion of high molecular weight compounds through sclera. Invest Ophthalmol Vis Sci. 2000;41:1181-1185. (Pubitemid 30187558)
20. Cruysberg LP, Nuijts RM, Geroski DH, et al. The influence of intraocular pressure on the transscleral diffusion of high-molecular-weight compounds. Invest Ophthalmol Vis Sci. 2005;46:3790-3794.
21. Rudnick DE, Noonan JS, Geroski DH, et al. The effect of intraocular pressure on human and rabbit scleral permeability. Invest Ophthalmol Vis Sci. 1999;40:3054-3058. (Pubitemid 29521626)