The use of technetium-99m radiolabeled human antimicrobial peptides for infection specific imaging

Mini-Reviews in Medicinal Chemistry

Volumn 8, Issue 10, 2008, Pages 1039-1052

  Brouwer, C P J M ^a,c   Sarda Mantel, L ^b   Meulemans, A ^b   Le Guludec, D ^b   Welling, M M ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b BICHAT HOSPITAL   (France)

^c Department of Microbiology ^*  (Netherlands)

Author keywords

Antimicrobial peptides; Infection detection; Molecular imaging; Pharmacology; Target delivery; Technetium 99m labeling; Treatment monitoring

Indexed keywords

ALPHA DEFENSIN; ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; BETA DEFENSIN; CATHELICIDIN; CECROPIN; DEFENSIN; DRUG CARRIER; FLUORODEOXYGLUCOSE F 18; GALLIUM 67; HISTATIN 5; HISTATIN DERIVATIVE; INDIUM 111; IODINE 123; IODINE 125; LACTOFERRIN; MELITTIN; METICILLIN; PEPTIDE DERIVATIVE; PROLINE; PROTEGRIN; PROTEIN DERIVATIVE; RADIOPHARMACEUTICAL AGENT; RECOMBINANT LACTOFERRIN; RECOMBINANT PROTEIN; RHENIUM 188; TECHNETIUM 99M; UBIQUICIDIN DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ANTIMICROBIAL CATIONIC PEPTIDE; DIAGNOSTIC AGENT; PEPTIDE FRAGMENT; TECHNETIUM; TECHNETIUM 99M UBIQUICIDIN(29 41); TECHNETIUM 99M UBIQUICIDIN(29-41); TECHNETIUM COMPLEX;

ALKALINITY; AMINO TERMINAL SEQUENCE; ANTIMICROBIAL ACTIVITY; BACTERIAL INFECTION; BINDING SITE; CELL LABELING; CHELATION; CLINICAL TRIAL; DISEASE COURSE; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG INDUSTRY; DRUG LABELING; DRUG MONITORING; DRUG PENETRATION; DRUG POTENCY; DRUG PURIFICATION; DRUG RESEARCH; DRUG SAFETY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; DRUG TOLERABILITY; GAMMA RADIATION; GOOD MANUFACTURING PRACTICE; HUMAN; HYDROPHILICITY; HYDROPHOBICITY; IMMUNE RESPONSE; INFECTION; INFLAMMATION; ISOTOPE LABELING; MALIGNANT NEOPLASTIC DISEASE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL ACTIVITY; MOLECULAR IMAGING; MORTALITY; MULTIDRUG RESISTANCE; MYCOSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PARASITOSIS; PATHOPHYSIOLOGY; PATIENT CARE; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; REVIEW; SHORT COURSE THERAPY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SOLID PHASE SYNTHESIS; URINARY EXCRETION; VIRUS INFECTION; ANIMAL; ANTIBIOTIC RESISTANCE; SCINTISCANNING;

ANIMALS; ANTI-INFECTIVE AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIAL INFECTIONS; DRUG RESISTANCE, BACTERIAL; HUMANS; ORGANOTECHNETIUM COMPOUNDS; PEPTIDE FRAGMENTS; RADIOPHARMACEUTICALS; TECHNETIUM;

EID: 56049123895     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/138955708785740670     Document Type: Review

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