Apparent tolerance of turkey vultures (Cathartes aura) to the non-steroidal anti-inflammatory drug diclofenac

Environmental Toxicology and Chemistry

Volumn 27, Issue 11, 2008, Pages 2341-2345

  Rattner, Barnett A ^a   Whitehead, Maria A ^b   Gasper, Grace ^b   Meteyer, Carol U ^c   Link, William A ^a   Taggart, Mark A ^d,e   Meharg, Andrew A ^d   Pattee, Oliver H ^a   Pain, Deborah J ^f  

^a PATUXENT WILDLIFE RESEARCH CENTER   (United States)

^b International Center for Birds of Prey   (United States)

^c NATIONAL WILDLIFE HEALTH CENTER   (United States)

^d UNIVERSITY OF ABERDEEN   (United Kingdom)

^e UNIVERSITY OF CASTILLA LA MANCHA   (Spain)

^f RSPB CENTRE FOR CONSERVATION SCIENCE   (United Kingdom)

Author keywords

Diclofenac; Scavenging birds; Species sensitivity; Vultures

Indexed keywords

ACIDS; GYPSUM; ORGANIC ACIDS;

AVIAN SPECIES; BLOOD SAMPLES; BODY WEIGHTS; CYCLOOXYGENASE; CYCLOOXYGENASE-2 INHIBITORS; DICLOFENAC; DIFFERENTIAL SENSITIVITIES; INFLAMMATORY DRUGS; LETHAL DOSES; OLD WORLDS; PLASMA CHEMISTRIES; SPECIES SENSITIVITY; URIC ACIDS; VULTURES; WIDESPREAD USES;

PLASMAS;

DICLOFENAC; URIC ACID;

BLOOD; BODY MASS; DOSE-RESPONSE RELATIONSHIP; DRUG RESISTANCE; ECOTOXICOLOGY; INHIBITOR; MORTALITY; POISONING; POLLUTION EFFECT; RAPTOR; SCAVENGING (FEEDING); SENSITIVITY ANALYSIS;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPSY; BIRD; BLOOD SAMPLING; CATHARTES AURA; CONTROLLED STUDY; FEMALE; GOUT; KIDNEY; KIDNEY NECROSIS; LIVER; MALE; NONHUMAN; PRIORITY JOURNAL; TOXICITY; URIC ACID BLOOD LEVEL;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIRDS; DICLOFENAC; DRUG TOLERANCE; FEMALE; MALE; SPECIES SPECIFICITY;

ASIA; EURASIA; INDIA; SOUTH ASIA;

AVES; CATHARTES; CATHARTES AURA; GYPS;

EID: 56049113009     PISSN: 07307268     EISSN: None     Source Type: Journal    
DOI: 10.1897/08-123.1     Document Type: Article

References (29)

1. Oaks JL, Gilbert M, Virani MZ, Watson RT, Meteyer CU, Rideout BA, Shivaprasad HL, Ahmed S, Chaudhry MJI, Arshad M, Mahmood S, Ali A, Khan AA. 2004. Diclofenac residues as the cause of vulture population decline in Pakistan. Nature 427:630-633.
2. Green RE, Newton I, Shultz S, Cunningham AA, Gilbert M, Pain DJ, Prakash V. 2004. Diclofenac poisoning as a cause of vulture population declines across the Indian subcontinent. J Appl Ecol 41:793-800.
3. Shultz S, Baral HS, Charman S, Cunningham AA, Das D, Ghalsasi GR, Goudar MS, Green RE, Jones A, Nighot P, Pain DJ, Prakash V. 2004. Diclofenac poisoning is widespread in declining vulture populations across the Indian subcontinent. Proc Royal Soc Lond B 271(Suppl):S458-S460.
4. Green RE, Taggart MA, Das D, Pain DJ, Kumar CS, Cunningham AA, Cuthbert R. 2006. Collapse of Asian vulture populations: Risk of mortality from residues of the veterinary drug diclofenac in carcasses of treated cattle. J Appl Ecol 43:949-956.
5. Green RE, Taggart MA, Senacha KR, Raghavan B, Pain DJ, Jhala Y, Cuthbert R. 2007. Rate of decline of the oriental white-backed vulture population in India estimated from a survey of diclofenac residues in carcasses of ungulates. PLoS One 2:e686.
6. Swan GE, Cuthbert R, Quevedo M, Green RE, Pain DJ, Bartels P, Cunningham AA, Duncan N, Meharg AA, Oaks JL, Parry-Jones J, Shultz S, Taggart MA, Verdoorn G, Wolter K. 2006. Toxicity of diclofenac to Gyps vultures. Biol Lett 2:279-282.
7. Meteyer CU, Rideout BR, Gilbert M, Shivaprasad HL, Oaks JL. 2005. Pathology and proposed pathophysiology of diclofenac poisoning in free-living and experimentally exposed oriental white-backed vultures (Gyps bengalensis). J Wildl Dis 41:707-716.
8. Naidoo V, Duncan N, Bekker L, Swan G. 2007. Validating the domestic fowl as a model to investigate the pathophysiology of diclofenac in Gyps vultures. Environ Toxicol Pharmacol 24:260-266.
9. Swan G, Naidoo V, Cuthbert R, Green RE, Pain DJ, Swarup D, Prakash V, Taggart M, Bekker L, Das D, Diekmann J, Diekmann M, Killian E, Meharg A, Patra RC, Saini M, Wolter K. 2006. Removing the threat of diclofenac to critically endangered Asian vultures. PLoS Biology 4:e66.
10. Sweetman S. 2006. Martindale - The Complete Drug Reference, 35th ed. Pharmaceutical Press, London, UK.
11. Cuthbert R, Parry-Jones J, Green RE, Pain DJ. 2007. NSAIDs and scavenging birds: Potential impacts beyond Asia's critically endangered vultures. Biol Lett 3:90-93.
12. Henny CJ, Blus LJ, Kolbe EJ, Fitzner RE. 1985. Organophosphate insecticide (famphur) topically applied to cattle kills magpies and hawks. J Wildl Manag 49:648-658.
13. Henny CJ, Kolbe EJ, Hill EF, Blus LJ. 1987. Case histories of bald eagles and other raptors killed by organophosphorus insecticides topically applied to livestock. J Wildl Dis 23:292-295.
14. Langelier KM. 1993. Barbiturate poisoning of twenty-nine bald eagles. In Redig PT, Cooper JE, Remple JD, Hunter DB, eds, Raptor Biomedicine. University of Minnesota, Minneapolis, MN, USA, pp 231-232.
15. Mineau P, Fletcher MR, Glaser LC, Thomas NJ, Brassard C, Wilson LK, Elliott JE, Lyon LA, Henny CJ, Bollinger T, Porter SL. 1999. Poisoning of raptors with organophosphorus and carbamate pesticides with emphasis on Canada, U.S. and U.K. J Raptor Res 33:1-35.
16. Thomas NJ. 1999. Barbiturates. In Friend M, Franson JC, technical eds, Field Manual of Wildlife Diseases, General Field Procedures and Diseases of Birds. U.S. Geological Survey, Biological Resources Division, Reston, VA, pp 349-350.
17. Klein PN, Charmatz K, Langenberg J. 1994. The effect of flunixin meglumine (Banamine®) on the renal function in northern bobwhite (Colinus virginianus): An avian model. Proceedings, Annual Conference of the American Association of Zoo Veterinarians and Association of Reptilian and Amphibian Veterinarians, Pittsburgh, PA, October 22-27, pp 129-131.
18. Baert K, De Backer P. 2003. Comparative pharmacokinetics of three non-steroidal anti-inflammatory drugs in five species of birds. Comp Biochem Physiol C 134:25-33.
19. Mulcahy DM, Tuomi P, Larsen RS. 2003. Differential mortality of male spectacled eiders (Somateria fischeri) and king eiders (Somateria spectabilis) subsequent to anesthesia with propofol, bupivacaine, and ketoprofen. Journal of Avian Medicine and Surgery 17:117-123.
20. Daughton CG, Ternes TA. 1999. Pharmaceuticals and personal care products in the environment: Agents of subtle change? Environ Health Perspect 107(Suppl 6):907-938.
21. Kolpin DW, Furlong ET, Meyers MT, Thurman EM, Zaugg SD, Barber LB, Buxton HT. 2002. Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: A national reconnaissance. Environ Sci Technol 36:1202-1211.
22. Beaty BJ, Calisher CH, Shope RE. 1989. Arboviruses. In Schmidt NJ, Emmons RW, eds, Diagnostic Procedures for Viral, Rickettsial and Chlamydial Infections, 6th ed. American Public Health Association, Washington, DC, pp 797-856.
23. Docherty DE, Long RR, Griffin KM, Saito EK. 2004. Corvidae feather pulp and West Nile Virus detection. Emerg Infect Dis 10:907-909.
24. Taggart MA, Senacha KR, Green RE, Jhala YV, Raghavan B, Rahmani AR, Cuthbert R, Pain DJ, Meharg AA. 2007. Diclofenac residues in carcasses of domestic ungulates available to vultures in India. Environ Int 33:759-765.
25. Cray C, Zaias J. 2004. Laboratory procedures. In Rupley A, Schulte M, eds, Veterinary Clinics of North America: Exotics Animal Practice. Elsevier, New York, NY, USA, pp 487-518.
26. Cray C, Rodriguez M, Zaias J. 2007. Protein electrophoresis of psittacine plasma. Vet Clin Pathol 36:67-72.
27. Lunn DJ, Thomas A, Best N, Spiegelhalter D. 2000. WinBUGS - A Bayesian modelling framework: Concepts, structure, and extensibility. Stat Comp 10:325-337.
28. Gee GF, Carpenter JW, Hensler GH. 1981. Species differences in hematological values of captive cranes, geese, raptors, and quail. J Wildl Manag 45:463-483.
29. Polo FJ, Celdran JF, Peinado VI, Viscor G, Palomeque J. 1992. Hematological values for four species of birds of prey. Condor 94:1007-1013.