Biotransformation of 2,3,3,3-tetrafluoropropene (HFO-1234yf)

Toxicology and Applied Pharmacology

Volumn 233, Issue 2, 2008, Pages 323-332

  Schuster, Paul ^a   Bertermann, Rüdiger ^a   Snow, Timothy A ^a,b   Han, Xing ^a,b   Rusch, George M ^a,c   Jepson, Gary W ^a,b   Dekant, Wolfgang ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b DUPONT COMPANY   (United States)

^c HONEYWELL   (United States)

Author keywords

Biotransformation; Haloolefins; HFO 1234yf; Mercapturic acids

Indexed keywords

2,3,3,3 TETRAFLUOROEPOXYPROPANE; 2,3,3,3 TETRAFLUOROPROPENE; 3,3,3 TRIFLUORO 1 HYDROXYACETONE; 3,3,3 TRIFLUORO 1,2 DIHYDROXYPROPANE; 3,3,3 TRIFLUOROACETONE; 3,3,3 TRIFLUOROLACTIC ACID; ACETIC ACID DERIVATIVE; CYSTEINE DERIVATIVE; CYTOCHROME P450 2E1; FLUORINE DERIVATIVE; FLUOROCARBON; GLUTATHIONE; HALOOLEFIN; HYDROXYL GROUP; N ACETYL S (3,3,3 TRIFLUORO 2 HYDROXYPROPYL)CYSTEINE; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOTRANSFORMATION; CONJUGATION; DIASTEREOISOMER; ENVIRONMENTAL EXPOSURE; ENZYME MECHANISM; FLUORINE NUCLEAR MAGNETIC RESONANCE; GAS CHROMATOGRAPHY; HALF LIFE TIME; HYDROLYSIS; IN VITRO STUDY; INHALATION; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MALE; MASS SPECTROMETRY; METABOLITE; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RABBIT; RAT; RING OPENING; URINARY EXCRETION;

ANIMALS; BIOTRANSFORMATION; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 CYP2E1; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUOROCARBONS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MICROSOMES, LIVER; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY; TIME FACTORS;

ANIMALIA; MUS; ORYCTOLAGUS CUNICULUS; RATTUS; TRIFLUORO;

EID: 56049104200     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.08.018     Document Type: Article

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