Intergenerational CAG repeat instability is highly heritable in Huntington's disease

Journal of Medical Genetics

Volumn 45, Issue 11, 2008, Pages 766-

  Aziz, N A ^a   van Belzen, M J ^a   Ross, R A C ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BIRTH ORDER; GENETIC COUNSELING; GENETIC VARIABILITY; HUMAN; HUNTINGTON CHOREA; INHERITANCE; LETTER; NUCLEOTIDE REPEAT; PARENTAL AGE; PRIORITY JOURNAL; SEMEN ANALYSIS;

ADOLESCENT; CHILD; FATHERS; HUMANS; HUNTINGTON DISEASE; MALE; MICROSATELLITE INSTABILITY; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; SPERMATOZOA; TRINUCLEOTIDE REPEATS;

EID: 56049100944     PISSN: 00222593     EISSN: 14686244     Source Type: Journal    
DOI: 10.1136/jmg.2008.062133     Document Type: Letter

References (2)

1. Wheeler VC, Persichetti F, McNeil SM, Mysore JS, Mysore SS, MacDonald ME, Myers RH, Gusella JF, Wexler NS; US-Venezuela Collaborative Research Group. Factors associated with HD CAG repeat instability in Huntington disease. J Med Genet 2007; 44:695-701.
2. De Rooij KE, De Koning Gans PA, Skraastad MI, Belfroid RD, Vegter-Van Der Vlis M, Roos BA, Bakker E, Van Ommen GJ, Den Dunnen JT, Losekoot M. Dynamic mutation in Dutch Huntington's disease patients: increased paternal repeat instability extending to within the normal size range. J Med Genet 1993;30:996-1002.