Characterization of the in situ structural and interfacial properties of the cationic hydrophobic heteropolypeptide, KL4, in lung surfactant bilayer and monolayer models at the air - Water interface: Implications for pulmonary surfactant delivery

Molecular Pharmaceutics

Volumn 5, Issue 5, 2008, Pages 681-695

  Mansour, Heidi M ^a,b   Damodaran, Srinivasan ^b   Zografi, George ^b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Bilayer monolayer equilibria; Biomacromolecule conformation secondary structure; In situ surface circular dichroism; Langmuir films; Molecular interactions; Phase transitions; Phospholipids; Solid state; Surface structure; Water vapor absorption hydration

Indexed keywords

DIPALMITOYLPHOSPHATIDYLCHOLINE; GLYCEROL; LUNG SURFACTANT; LYSINE 4 [4 LYSYLLEUCINE]; PALMITOYLOLEOYLPHOSPHATIDYLGLYCEROL; POLYPEPTIDE; UNCLASSIFIED DRUG; WATER;

ALPHA HELIX; ARTICLE; BETA SHEET; CHEMICAL INTERACTION; CIRCULAR DICHROISM; DIFFERENTIAL SCANNING CALORIMETRY; HYDROPHOBICITY; LANGMUIR BLODGETT FILM; MONOLAYER CULTURE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; SOLID STATE; STRUCTURE ANALYSIS; SURFACE PROPERTY; WATER VAPOR; X RAY POWDER DIFFRACTION;

1,2-DIPALMITOYLPHOSPHATIDYLCHOLINE; ADSORPTION; AIR; CALORIMETRY, DIFFERENTIAL SCANNING; CIRCULAR DICHROISM; DRUG ADMINISTRATION ROUTES; LIPID BILAYERS; MODELS, BIOLOGICAL; PEPTIDES; PHASE TRANSITION; PHOSPHATIDYLGLYCEROLS; POWDER DIFFRACTION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PULMONARY SURFACTANTS; SURFACE PROPERTIES; TEMPERATURE; WATER;

EID: 56049099316     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp700123p     Document Type: Article

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