Disruption of a mitochondrial RNA-binding protein gene results in decreased cytochrome b expression and a marked reduction in ubiquinol-cytochrome c reductase activity in mouse heart mitochondria

Biochemical Journal

Volumn 416, Issue 1, 2008, Pages 15-26

  Xu, Fenghao ^a   Ackerley, Cameron ^a   Maj, Mary C ^a   Addis, Jane B L ^a   Levandovskiy, Valeriy ^a   Lee, Jisoo ^a   MacKay, Nevena ^a   Cameron, Jessie M ^a   Robinson, Brian H ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Cytochrome b; Mitochondrion; Pentatricopeptide repeat (PPR) protein; Pentatricopeptide repeat domain protein 2 (PTCD2); RNA processing

Indexed keywords

CARDIOMYOCYTES; CATALYTIC CORE; COMPLEX ACTIVITY; CYTOCHROME B; CYTOCHROME C; ENCODED PROTEINS; HEART FAILURE; MITOCHONDRIAL DNA; MITOCHONDRIAL FUNCTION; MOUSE HEART; NADH DEHYDROGENASE; NORTHERN BLOTTING; PENTATRICOPEPTIDE REPEAT (PPR) PROTEIN; PENTATRICOPEPTIDE REPEAT DOMAIN PROTEIN 2 (PTCD2); PENTATRICOPEPTIDE REPEATS; REDUCTASE ACTIVITY; RNA METABOLISMS; RNA PROCESSING; RNA-BINDING PROTEIN; SKELETAL MUSCLE; UBIQUINOL;

DNA; GENES; MAMMALS; MITOCHONDRIA; PLANTS (BOTANY); RNA;

NUCLEIC ACIDS;

BINDING PROTEIN; CYTOCHROME B; MESSENGER RNA; MITOCHONDRIAL DNA; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL RNA; PENTATRICOPEPTIDE REPEAT PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; RNA BINDING PROTEIN; UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG; PTCD2 PROTEIN, MOUSE; RNA; RNA, MITOCHONDRIAL;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE DISRUPTION; HEART FAILURE; HEART MITOCHONDRION; HEART MUSCLE CELL; HEART VENTRICLE; HOMOZYGOSITY; HUMAN; HUMAN CELL; LIVER PARENCHYMA; MOUSE; NONHUMAN; NORTHERN BLOTTING; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA METABOLISM; RNA PROCESSING; SKELETAL MUSCLE; ANIMAL; BIOSYNTHESIS; ELECTRON MICROSCOPY; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HELA CELL; LIVER MITOCHONDRION; METABOLISM; MITOCHONDRIAL GENE; MUSCLE MITOCHONDRION; PHYSIOLOGY; ULTRASTRUCTURE;

MAMMALIA; MUS;

ANIMALS; CYTOCHROMES B; ELECTRON TRANSPORT COMPLEX III; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, MITOCHONDRIAL; HELA CELLS; HUMANS; MICE; MICROSCOPY, ELECTRON; MITOCHONDRIA, HEART; MITOCHONDRIA, LIVER; MITOCHONDRIA, MUSCLE; MITOCHONDRIAL PROTEINS; RNA; RNA-BINDING PROTEINS;

EID: 56049093869     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20080847     Document Type: Article

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