Ubc9-mediated sumoylation leads to transcriptional repression of IRF-1

Biochemical and Biophysical Research Communications

Volumn 377, Issue 3, 2008, Pages 952-956

  Kim, Eun Joo ^a   Park, Jong Sup ^b   Um, Soo Jong ^c  

^a Dankook University   (South Korea)

^b The Catholic University of Korea   (South Korea)

^c Sejong University   (South Korea)

Author keywords

IRF; SUMO; Sumoylation; Transcriptional repression; Ubc9

Indexed keywords

INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; INTERFERON REGULATORY FACTOR 1; PROTEIN UBC9; SUMO 1 PROTEIN; SUMO PROTEIN;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SUMOYLATION; TRANSCRIPTION REGULATION; YEAST;

ANIMALS; CELL LINE, TUMOR; DOWN-REGULATION; GENE EXPRESSION REGULATION; HUMANS; INTERFERON REGULATORY FACTOR-1; INTERFERON REGULATORY FACTOR-2; MICE; NIH 3T3 CELLS; REPRESSOR PROTEINS; SUMO-1 PROTEIN; TRANSCRIPTION, GENETIC; TWO-HYBRID SYSTEM TECHNIQUES; UBIQUITIN-CONJUGATING ENZYMES;

EID: 56049091716     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.10.092     Document Type: Article

References (26)

1. Sato M., Taniguchi T., and Tanaka N. The interferon system and interferon regulatory factor transcription factors-studies from gene knockout mice. Cytokine Growth Factor Rev. 12 (2001) 133-142
2. Mamane Y., Heylbroeck C., Genin P., Algarte M., Servant M.J., LePage C., DeLuca C., Kwon H., Lin R., and Hiscott J. Interferon regulatory factors: the next generation. Gene 237 (1999) 1-14
3. Escalante C.R., Yie J., Thanos D., and Aggarwal A.K. Structure of IRF-1 with bound DNA reveals determinants of interferon regulation. Nature 391 (1998) 103-106
4. Taniguchi T., Lamphier M.S., and Tanaka N. IRF-1: the transcription factor linking the interferon response and oncogenesis. Biochim. Biophys. Acta 1333 (1997) M9-17
5. Kirchhoff S., Schaper F., and Hauser H. Interferon regulatory factor 1 (IRF-1) mediates cell growth inhibition by transactivation of downstream target genes. Nucleic Acids Res. 21 (1993) 2881-2889
6. Willman C.L., Sever C.E., Pallavicini M.G., Harada H., Tanaka N., Slovak M.L., Yamamoto H., Harada K., Meeker T.C., List A.F., and Taniguchi T. Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia. Science 259 (1993) 968-971
7. Tanaka N., Ishihara M., Kitagawa M., Harada H., Kimura T., Matsuyama T., Lamphier M.S., Aizawa S., Mak T.W., and Taniguchi T. Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1. Cell 77 (1994) 829-839
8. Tamura T., Ishihara M., Lamphier M.S., Tanaka N., Oishi I., Aizawa S., Matsuyama T., Mak T.W., Taki S., and Taniguchi T. An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes. Nature 376 (1995) 596-599
9. Nozawa H., Oda E., Nakao K., Ishihara M., Ueda S., Yokochi T., Ogasawara K., Nakatsuru Y., Shimizu S., Ohira Y., Hioki K., Aizawa S., Ishikawa T., Katsuki M., Muto T., Taniguchi T., and Tanaka N. Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53. Genes Dev. 13 (1999) 1240-1245
10. Kim E.J., Lee J.M., Namkoong S.E., Um S.J., and Park J.S. Interferon regulatory factor-1 mediates interferon-gamma-induced apoptosis in ovarian carcinoma cells. J. Cell. Biochem. 85 (2002) 369-380
11. Kroger A., Koster M., Schroeder K., Hauser H., and Mueller P.P. Activities of IRF-1. J. Interferon Cytokine Res. 22 (2002) 5-14
12. Lin R., Mustafa A., Nguyen H., Gewert D., and Hiscott J. Mutational analysis of interferon (IFN) regulatory factors 1 and 2. Effects on the induction of IFN-beta gene expression. J. Biol. Chem. 269 (1994) 17542-17549
13. Paun A., and Pitha P.M. The IRF family revisited. Biochimie 89 (2007) 744-753
14. Wang Y., Liu D., Chen P., Koeffler H.P., Tong X., and Xie D. Negative feedback regulation of IFN-gamma pathway by IFN regulatory factor 2 in esophageal cancers. Cancer Res. 68 (2008) 1136-1143
15. Hida S., Tadachi M., Saito T., and Taki S. Negative control of basophil expansion by IRF-2 critical for the regulation of Th1/Th2 balance. Blood 106 (2005) 2011-2017
16. Rodriguez M.S., Dargemont C., and Hay R.T. SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting. J. Biol. Chem. 276 (2001) 12654-12659
17. Sampson D.A., Wang M., and Matunis M.J. The small ubiquitin-like modifier-1 (SUMO-1) consensus sequence mediates Ubc9 binding and is essential for SUMO-1 modification. J. Biol. Chem. 276 (2001) 21664-21669
18. Pichler A., Gast A., Seeler J.S., Dejean A., and Melchior F. The nucleoporin RanBP2 has SUMO1 E3 ligase activity. Cell 108 (2002) 109-120
19. S Johnson E. Protein modification by SUMO. Annu. Rev. Biochem. 73 (2004) 355-382
20. Hay R.T. SUMO: a history of modification. Mol. Cell 18 (2005) 1-12
21. Bossis G., and Melchior F. SUMO: regulating the regulator. Cell Div. (2006) 13
22. Kim E.J., Park J.S., and Um S.J. Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo. J. Biol. Chem. 277 (2002) 32020-32028
23. Nakagawa K., and Yokosawa H. PIAS3 induces SUMO-1 modification and transcriptional repression of IRF-1. FEBS Lett. 530 (2002) 204-208
24. J. Park, K. Kim, E.J. Lee, Y.J. Seo, S.N. Lim, K. Park, S.B. Rho, S.H. Lee, J.H. Lee, Elevated level of SUMOylated IRF-1 in tumor cells interferes with IRF-1-mediated apoptosis, Proc. Natl. Acad. Sci. USA 104 (2007) 17028-17033.
25. Han K.J., Jiang L., and Shu H.B. Regulation of IRF2 transcriptional activity by its sumoylation. Biochem. Biophys. Res. Commun. 372 (2008) 772-778
26. Kubota T., Matsuoka M., Chang C.H., Tailor P., Sasaki T., Tashiro M., Kato A., and Ozato K. Virus infection triggers SUMOylation of IRF3 and IRF7, leading to the negative regulation of type I interferon gene expression. J. Biol. Chem. 283 (2008) 25660-25670