Association between a disrupted-in-schizophrenia 1 (DISC1) single nucleotide polymorphism and schizophrenia in a combined Scandinavian case-control sample

Schizophrenia Research

Volumn 106, Issue 2-3, 2008, Pages 237-241

  Saetre, Peter ^a   Agartz, Ingrid ^a,b,c   De Franciscis, Alessandra ^a   Lundmark, Per ^d   Djurovic, Srdjan ^b,e   Kähler, Anna ^b,e   Andreassen, Ole A ^b,e   Jakobsen, Klaus D ^f,g   Rasmussen, Henrik B ^f   Werge, Thomas ^f   Hall, Håkan ^a   Terenius, Lars ^a   Jönsson, Erik G ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF OSLO   (Norway)

^c DIAKONHJEMMET HOSPITAL   (Norway)

^d UPPSALA UNIVERSITY   (Sweden)

^e ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^f Mental Health Services CPH   (Denmark)

^g UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Association; Disrupted in schizophrenia 1 (DISC1); rs3737597; Schizophrenia

Indexed keywords

BRAIN PROTEIN; DISRUPTED IN SCHIZOPHRENIA 1 PROTEIN; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ALLELE; ARTICLE; CASE CONTROL STUDY; GENE DISRUPTION; GENE FREQUENCY; GENE REPLICATION; GENE SEGREGATION; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; PRIORITY JOURNAL; SCANDINAVIA; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 56049088969     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.schres.2008.08.024     Document Type: Article

References (43)

1. Barrett J.C., Fry B., Maller J., and Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21 (2005) 263-265
2. Bellon A. New genes associated with schizophrenia in neurite formation: a review of cell culture experiments. Mol. Psychiatry 12 7 (2007) 620-629
3. Blackwood D.H., Fordyce A., Walker M.T., St Clair D.M., Porteous D.J., and Muir W.J. Schizophrenia and affective disorders-cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. Am. J. Hum. Genet 69 2 (2001) 428-433
4. Callicott J.H., Straub R.E., Pezawas L., Egan M.F., Mattay V.S., Hariri A.R., Verchinski B.A., Meyer-Lindenberg A., Balkissoon R., Kolachana B., Goldberg T.E., and Weinberger D.R. Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 8627-8632
5. Cannon T.D., Hennah W., van Erp T.G., Thompson P.M., Lönnqvist J., Huttunen M., Gasperoni T., Tuulio-Henriksson A., Pirkola T., Toga A.W., Kaprio J., Mazziotta J., and Peltonen L. Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory. Arch. Gen. Psychiatry 62 (2005) 1205-1213
6. Crow T.J. How and why genetic linkage has not solved the problem of psychosis: review and hypothesis. Am. J. Psychiatry 164 1 (2007) 13-21
7. Duan X., Chang J.H., Ge S., Faulkner R.L., Kim J.Y., Kitabatake Y., Liu X.B., Yang C.H., Jordan J.D., Ma D.K., Liu C.Y., Ganesan S., Cheng H.J., Ming G.L., Lu B., and Song H. Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. Cell 130 6 (2007) 1146-1158
8. Dudbridge F. Pedigree disequilibrium tests for multilocus haplotypes. Genet. Epidemiol. 25 2 (2003) 115-121
9. Dudbridge, F., 2006. UNPHASED User Guide. Technical report 2006/5.
10. Ekelund J., Hovatta I., Parker A., Paunio T., Varilo T., Martin R., Suhonen J., Ellonen P., Chan G., Sinsheimer J.S., Sobel E., Juvonen H., Arajarvi R., Partonen T., Suvisaari J., Lonnqvist J., Meyer J., and Peltonen L. Chromosome 1 loci in Finnish schizophrenia families. Hum. Mol. Genet. 10 15 (2001) 1611-1617
11. Ekelund J., Hennah W., Hiekkalinna T., Parker A., Meyer J., Lonnqvist J., and Peltonen L. Replication of 1q42 linkage in Finnish schizophrenia pedigrees. Mol. Psychiatry 9 11 (2004) 1037-1041
12. Fallin M.D., Lasseter V.K., Avramopoulos D., Nicodemus K.K., Wolyniec P.S., McGrath J.A., Steel G., Nestadt G., Liang K.Y., Huganir R.L., Valle D., and Pulver A.E. Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios. Am. J. Hum. Genet. 77 6 (2005) 918-936
13. Hansen T., Olsen L., Lindow M., Jakobsen K.D., Ullum H., Jonsson E., Andreassen O.A., Djurovic S., Mjelle I., Agartz I., Hall H., Timm S., Wang A.G., and Werge T. Brain Expressed microRNAs Implicated in Schizophrenia Etiology. PLoS ONE 2 (2007) e873
14. Hennah W., Varilo T., Kestila M., Paunio T., Arajarvi R., Haukka J., Parker A., Martin R., Levitzky S., Partonen T., Meyer J., Lonnqvist J., Peltonen L., and Ekelund J. Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects. Hum. Mol. Genet. 12 23 (2003) 3151-3159
15. Hennah W., Thomson P., Peltonen L., and Porteous D. Genes and schizophrenia: beyond schizophrenia: the role of DISC1 in major mental illness. Schizophr. Bull. 32 3 (2006) 409-416
16. Hennah W., Thomson P., McQuillin A., Bass N., Loukola A., Anjorin A., Blackwood D., Curtis D., Deary I.J., Harris S.E., Isometsa E.T., Lawrence J., Lonnqvist J., Muir W., Palotie A., Partonen T., Paunio T., Pylkko E., Robinson M., Soronen P., Suominen K., Suvisaari J., Thirumalai S., Clair D.S., Gurling H., Peltonen L., and Porteous D. DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder. Mol. Psychiatry (2008) Electronic publication ahead of print
17. Hodgkinson C.A., Goldman D., Jaeger J., Persaud S., Kane J.M., Lipsky R.H., and Malhotra A.K. Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder. Am. J. Hum. Genet. 75 (2004) 862-872
18. Hovatta I., Varilo T., Suvisaari J., Terwilliger J.D., Ollikainen V., Arajärvi R., Juvonen H., Kokko-Sahin M.L., Väisänen L., Mannila H., Lönnqvist J., and Peltonen L. A genomewide screen for schizophrenia genes in an isolated Finnish subpopulation, suggesting multiple susceptibility loci. Am. J. Hum. Genet. 65 (1999) 1114-1124
19. Hwu H.G., Liu C.M., Fann C.S., Ou-Yang W.C., and Lee S.F. Linkage of schizophrenia with chromosome 1q loci in Taiwanese families. Mol. Psychiatry 8 4 (2003) 445-452
20. James R., Adams R.R., Christie S., Buchanan S.R., Porteous D.J., and Millar J.K. Disrupted in Schizophrenia 1 (DISC1) is a multicompartmentalized protein that predominantly localizes to mitochondria. Mol. Cell. Neurosci. 26 1 (2004) 112-122
21. Jönsson E.G., Larsson K., Vares M., Hansen T., Wang A.G., Djurovic S., Rønningen K.S., Andreassen O.A., Agartz I., Werge T., Terenius L., and Hall H. Two methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms, schizophrenia and bipolar disorder: an association study. Am J Med Genet Part B. 147B 6 (2008) 976-982
22. Kähler, A., Djurovic, S., Kulle, B., Jönsson, E.G., Agartz, I., Hall, H., Opjordsmoen, S., Jakobsen, K.D., Hansen, T., Melle, I., Steen, V.M., Werge, T., Andreassen, O.A., Electronic publication ahead of print. Association analysis of schizophrenia on 18 candidate genes involved in neuronal migration: MGDA1 as a new susceptibility gene. Am J Med Genet Part B.
23. Kamiya A., Kubo K., Tomoda T., Takaki M., Youn R., Ozeki Y., Sawamura N., Park U., Kudo C., Okawa M., Ross C.A., Hatten M.E., Nakajima K., and Sawa A. A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development. Nat. Cell Biol. 7 12 (2005) 1167-1178
24. Kim H.J., Park H.J., Jung K.H., Ban J.Y., Ra J., Kim J.W., Park J.K., Choe B.K., Yim S.V., Kwon Y.K., and Chung J.H. Association study of polymorphisms between DISC1 and schizophrenia in a Korean population. Neurosci. Lett. 430 1 (2008) 60-63
25. Kockelkorn T., Arai M., Matsumoto H., Fukuda N., Yamada K., Minabe Y., Toyota T., Ujike H., Sora I., Mori N., Yoshikawa T., and Itokawa M. Association study of polymorphisms in the 5′ upstream region of human DISC1 gene with schizophrenia. Neurosci. Lett. 368 (2004) 41-45
26. Lohmueller K.E., Pearce C.L., Pike M., Lander E.S., and Hirschhorn J.N. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat. Genet. 33 (2003) 177-182
27. Mackie S., Millar J.K., and Porteous D.J. Role of DISC1 in neural development and schizophrenia. Curr. Opin. Neurobiol. 17 1 (2007) 95-102
28. McClellan J.M., Susser E., and King M.C. Schizophrenia: a common disease caused by multiple rare alleles. Br. J. Psychiatry 190 (2007) 194-199
29. Millar J.K., Wilson-Annan J.C., Anderson S., Christie S., Taylor M.S., Semple C.A., Devon R.S., Clair D.M., Muir W.J., Blackwood D.H., and Porteous D.J. Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum. Mol. Genet. 9 9 (2000) 1415-1423
30. Millar J.K., Pickard B.S., Mackie S., James R., Christie S., Buchanan S.R., Malloy M.P., Chubb J.E., Huston E., Baillie G.S., Thomson P.A., Hill E.V., Brandon N.J., Rain J.C., Camargo L.M., Whiting P.J., Houslay M.D., Blackwood D.H., Muir W.J., and Porteous D.J. DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. Science 310 5751 (2005) 1187-1191
31. Miyoshi K., Honda A., Baba K., Taniguchi M., Oono K., Fujita T., Kuroda S., Katayama T., and Tohyama M. Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth. Mol. Psychiatry 8 7 (2003) 685-694
32. Ozeki Y., Tomoda T., Kleiderlein J., Kamiya A., Bord L., Fujii K., Okawa M., Yamada N., Hatten M.E., Snyder S.H., Ross C.A., and Sawa A. Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. Proc. Natl. Acad. Sci. U. S. A. 100 1 (2003) 289-294
33. Qu M., Tang F., Yue W., Ruan Y., Lu T., Liu Z., Zhang H., Han Y., Zhang D., and Wang F. Positive association of the Disrupted-in-Schizophrenia-1 gene (DISC1) with schizophrenia in the Chinese Han population. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 144 3 (2007) 266-270
34. Sanders A.R., Duan J., Levinson D.F., Shi J., He D., Hou C., Burrell G.J., Rice J.P., Nertney D.A., Olincy A., Rozic P., Vinogradov S., Buccola N.G., Mowry B.J., Freedman R., Amin F., Black D.W., Silverman J.M., Byerley W.F., Crowe R.R., Cloninger C.R., Martinez M., and Gejman P.V. No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics. Am. J. Psychiatry 165 4 (2008) 497-506
35. Song W., Li W., Feng J., Heston L.L., Scaringe W.A., and Sommer S.S. Identification of high risk DISC1 structural variants with a 2% attributable risk for schizophrenia. Biochem. Biophys. Res. Commun. 367 3 (2008) 700-706
36. St Clair D., Blackwood D., Muir W., Carothers A., Walker M., Spowart G., Gosden C., and Evans H.J. Association within a family of a balanced autosomal translocation with major mental illness. Lancet 336 (1990) 13-16
37. Thomson P.A., Wray N.R., Millar J.K., Evans K.L., Hellard S.L., Condie A., Muir W.J., Blackwood D.H., and Porteous D.J. Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population. Mol. Psychiatry 10 (2005) 657-668
38. Walsh T., McClellan J.M., McCarthy S.E., Addington A.M., Pierce S.B., Cooper G.M., Nord A.S., Kusenda M., Malhotra D., Bhandari A., Stray S.M., Rippey C.F., Roccanova P., Makarov V., Lakshmi B., Findling R.L., Sikich L., Stromberg T., Merriman B., Gogtay N., Butler P., Eckstrand K., Noory L., Gochman P., Long R., Chen Z., Davis S., Baker C., Eichler E.E., Meltzer P.S., Nelson S.F., Singleton A.B., Lee M.K., Rapoport J.L., King M.C., and Sebat J. Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science 320 5875 (2008) 539-543
39. Wang W.Y., Barratt B.J., Clayton D.G., and Todd J.A. Genome-wide association studies: theoretical and practical concerns. Nat. Rev. Genet. 2 (2005) 109-118
40. Wigginton J.E., and Abecasis G.R. PEDSTATS: descriptive statistics, graphics and quality assessment for gene mapping data. Bioinformatics 21 16 (2005) 3445-3447
41. Wood L.S., Pickering E.H., and Dechairo B.M. Significant support for DAO as a schizophrenia susceptibility locus: examination of five genes putatively associated with schizophrenia. Biol. Psychiatry 61 10 (2007) 1195-1199
42. Zhang X., Tochigi M., Ohashi J., Maeda K., Kato T., Okazaki Y., Kato N., Tokunaga K., Sawa A., and Sasaki T. Association study of the DISC1/TRAX locus with schizophrenia in a Japanese population. Schizophr. Res. 79 (2005) 175-180
43. Zhang F., Sarginson J., Crombie C., Walker N., St Clair D., and Shaw D. Genetic association between schizophrenia and the DISC1 gene in the Scottish population. Am. J. Med. Genet. B Neuropsychiatr. Genet. 141 (2006) 155-159